Title:
NUCLEIC ACID SEQUENCE WHICH ENCODES FOR AN AMINO ACID SEQUENCE CAPABLE OF BEING CYCLIZED WITHIN A CELL OR CELL MEMBRANE
Document Type and Number:
WIPO Patent Application WO2001034829
Kind Code:
A3
Abstract:
The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as a cyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation.
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Inventors:
CRAIK DAVID JAMES (AU)
ANDERSON MARILYN ANNE (AU)
JENNINGS CAMERON VICTOR (AU)
ANDERSON MARILYN ANNE (AU)
JENNINGS CAMERON VICTOR (AU)
Application Number:
PCT/AU2000/001352
Publication Date:
December 18, 2003
Filing Date:
November 03, 2000
Export Citation:
Assignee:
UNIV QUEENSLAND (AU)
UNIV LATROBE (AU)
CRAIK DAVID JAMES (AU)
ANDERSON MARILYN ANNE (AU)
JENNINGS CAMERON VICTOR (AU)
UNIV LATROBE (AU)
CRAIK DAVID JAMES (AU)
ANDERSON MARILYN ANNE (AU)
JENNINGS CAMERON VICTOR (AU)
International Classes:
C07K14/415; C07K16/16; C07K19/00; A01H5/00; C12N15/09; C12N15/29; C12P21/08; (IPC1-7): C12N15/29; C12N15/70; C07K14/415
Other References:
CRAIK ET AL., J. MOL. BIOL., vol. 294, no. 5, 17 December 1999 (1999-12-17), pages 1327 - 1336, XP004461807
DALY ET AL., J. BIOL. CHEM., vol. 275, no. 25, 23 June 2000 (2000-06-23), pages 19068 - 19075, XP002904946
DALY ET AL., BIOCHEMISTRY, vol. 38, no. 32, 10 August 1999 (1999-08-10), pages 10606 - 10614, XP002904947
SAETHER ET AL., BIOCHEMISTRY, vol. 34, no. 13, 4 April 1995 (1995-04-04), pages 4147 - 4158, XP002904948
TAM ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, no. 16, 3 August 1999 (1999-08-03), pages 8913 - 8918, XP002955358
PALLAGHY ET AL., PROTEIN SCI., vol. 3, no. 10, October 1994 (1994-10-01), pages 1833 - 1839, XP002921370
DALY ET AL., J. BIOL. CHEM., vol. 275, no. 25, 23 June 2000 (2000-06-23), pages 19068 - 19075, XP002904946
DALY ET AL., BIOCHEMISTRY, vol. 38, no. 32, 10 August 1999 (1999-08-10), pages 10606 - 10614, XP002904947
SAETHER ET AL., BIOCHEMISTRY, vol. 34, no. 13, 4 April 1995 (1995-04-04), pages 4147 - 4158, XP002904948
TAM ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, no. 16, 3 August 1999 (1999-08-03), pages 8913 - 8918, XP002955358
PALLAGHY ET AL., PROTEIN SCI., vol. 3, no. 10, October 1994 (1994-10-01), pages 1833 - 1839, XP002921370
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