Title:
NUCLEIC ACID STRUCTURE ANALYSIS METHOD AND NUCLEIC ACID STRUCTURE ANALYSIS DEVICE
Document Type and Number:
WIPO Patent Application WO/2023/171024
Kind Code:
A1
Abstract:
Provided is a nucleic acid structure analysis method comprising: a HAD-MSn analysis step (101) of dissociating ions derived from a test nucleic acid by introducing hydrogen radicals into a space containing the ions, and performing mass spectrometry of a plurality of thus generated fragment ions to collect information on the m/z of the plurality of fragment ions; and a structure estimation step (103) of estimating the structure of the test nucleic acid on the basis of the information on the m/z of the plurality of fragment ions obtained in the HAD-MSn analysis step. The present invention thereby makes it possible to handle precursor ions of various electric charges and facilitate structure estimation of nucleic acids based on mass spectra.
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Inventors:
YAMAUCHI SHOSEI (JP)
TAKAHASHI HIDENORI (JP)
TAKAHASHI HIDENORI (JP)
Application Number:
PCT/JP2022/040077
Publication Date:
September 14, 2023
Filing Date:
October 27, 2022
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2015133259A1 | 2015-09-11 |
Foreign References:
| JP2016223777A | 2016-12-28 |
Other References:
TAKAYAMA MITSUO: "The Characteristics of In-source Decay in Mass Spectrometric Degradation Methods ῍Hydrogen-Attachment Dissociation (HAD)῍", JOURNAL OF THE MASS SPECTROMETRY SOCIETY OF JAPAN, vol. 50, no. 6, 1 January 2002 (2002-01-01), pages 337 - 349, XP093090866
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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