Title:
NUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/181102
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound having an antiviral activity against at least HBVs and having low toxicity to a host cell. Provided is a compound represented by general formula (1) or a pharmaceutically acceptable salt thereof. In the formula, R represents a hydrogen atom, a cyano group, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, or an azide group. One preferred example of the compound is a compound wherein R represents a hydrogen atom or a pharmaceutically acceptable salt thereof.
Inventors:
MITSUYA HIROAKI (JP)
KONNO KIJU (JP)
SUGIHARA TAKUMI (JP)
KONNO KIJU (JP)
SUGIHARA TAKUMI (JP)
Application Number:
PCT/JP2018/011987
Publication Date:
October 04, 2018
Filing Date:
March 26, 2018
Export Citation:
Assignee:
YAMASA CORP (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
International Classes:
C07D487/04; A61K31/52; A61P31/20
Domestic Patent References:
| WO1990006671A2 | 1990-06-28 |
Foreign References:
| JPH04505768A | 1992-10-08 | |||
| US6001840A | 1999-12-14 | |||
| JPH07504185A | 1995-05-11 | |||
| JPH0656877A | 1994-03-01 | |||
| JPS63258891A | 1988-10-26 |
Other References:
HICKS, N. ET AL.: "The enzymatic synthesis and anti-HIV activity of 9- beta -D-2' -deoxy and 9- beta -D-2' , 3' -dideoxynucleosides of 2-aminopurine", ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol. 3, no. 3, 1992, pages 153 - 156, XP055612977, ISSN: 2040-2066
ELDRUP,A.B. ET AL.: "Structure-Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 9, 2004, pages 2283 - 2295, XP002391265, ISSN: 0022-2623, DOI: doi:10.1021/jm030424e
ELDRUP,A.B. ET AL.: "Structure-Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 9, 2004, pages 2283 - 2295, XP002391265, ISSN: 0022-2623, DOI: doi:10.1021/jm030424e
Attorney, Agent or Firm:
SIKS & CO. (JP)
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