Title:
NUTRITIONAL POLYPEPTIDE HAVING BRANCHED STRUCTURE AND EFFICIENT BROAD-SPECTRUM ANTIBACTERIAL AND ANTIFUNGAL FUNCTIONS
Document Type and Number:
WIPO Patent Application WO/2023/231052
Kind Code:
A1
Abstract:
A nutritional polypeptide having a branched structure and efficient broad-spectrum antibacterial and antifungal functions. The nutritional polypeptide having the branched structure is a polymer peptide which has a molecular weight of 3000-7000 Da and a polydispersity index of less than 1.2 and contains L-lysine and D-lysine structural units. The polypeptide having the branched structure has efficient broad-spectrum antimicrobial effects against bacteria, fungi and mycoplasmas at a low concentration, and does not generate drug resistance. Compared with common antimicrobial agents, the polypeptide has an excellent biocompatibility, no cytotoxicity, and no side effects on animals after intravenous injection, and can meet the antimicrobial requirements of intravenous injection in vivo. The degradation product of the polypeptide is lysine, which is an essential nutrient for organisms, and has no toxic or side effects. The polypeptide having the branched structure does not require a biological fermentation process, is completely chemically synthesized, has stable physical, chemical and biological properties, and can be combined with other materials by means of physical or chemical methods to synthesize or process same into various forms of materials while maintaining efficient antimicrobial properties.
Inventors:
GAO CHANGYOU (CN)
CAO WANGBEI (CN)
DONG XIAOFEI (CN)
CAO WANGBEI (CN)
DONG XIAOFEI (CN)
Application Number:
PCT/CN2022/097173
Publication Date:
December 07, 2023
Filing Date:
June 06, 2022
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
SHAOXING RESEARCH INSTITUTE OF ZHEJIANG UNIV (CN)
International Classes:
C07K14/00; A61K38/16; A61P31/04; A61P31/10
Domestic Patent References:
| WO2019099525A1 | 2019-05-23 | |||
| WO2019149121A1 | 2019-08-08 |
Foreign References:
| CN111808278A | 2020-10-23 | |||
| CN111454457A | 2020-07-28 | |||
| CN104650194A | 2015-05-27 |
Other References:
SZABÓ RITA, PEISER LEANNE, PLÜDDEMANN ANNETTE, BÖSZE SZILVIA, HEINSBROEK SIGRID, GORDON SIAMON, HUDECZ FERENC: "Uptake of branched polypeptides with poly[L-lys] backbone by bone-marrow culture-derived murine macrophages: the role of the class a scavenger receptor", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 6, 1 November 2005 (2005-11-01), US , pages 1442 - 1450, XP093116191, ISSN: 1043-1802, DOI: 10.1021/bc050168f
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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