OPTICALLY ACTIVE 'alpha'-SUBSTITUTED CARBOXYLIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Title:

OPTICALLY ACTIVE 'alpha'-SUBSTITUTED CARBOXYLIC ACID DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1995/034525

Kind Code:

A1

Abstract:

An optically active 'alpha'-substituted carboxylic acid derivative represented by general formula (I) wherein R1 represents hydroxy, -C(=CH2)-COOR3 or -CH(CH3)-COOR3; R2 represents methyl or chloro; R3 represents hydrogen or C1-C6 alkyl; n represents an integer of 1 or 2; and the asterisk represents asymmetric carbon, provided when R1 represents hydroxy, R2 represents chloro; and a process for producing the derivative or an enantiomer thereof by using a culture of a microorganism capable of asymmetrically hydrolyzing an ester linkage or a cell thereof which may have been suitably treated. These compounds are useful as the starting material of various liquid crystals and as an intermediate for synthesizing optically active drugs and pesticides.

Inventors:

OZAKI EIJI (JP)
URAGAKI TOSHITAKA (JP)
SAKASHITA KEIICHI (JP)
IKEMOTO TETSUYA (JP)
KOBAYASHI YOSHIMASA (JP)
SAKIMAE AKIHIRO (JP)

Application Number:

PCT/JP1995/001176

Publication Date:

December 21, 1995

Filing Date:

June 13, 1995

Export Citation:

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Assignee:

MITSUBISHI RAYON CO (JP)
OZAKI EIJI (JP)
URAGAKI TOSHITAKA (JP)
SAKASHITA KEIICHI (JP)
IKEMOTO TETSUYA (JP)
KOBAYASHI YOSHIMASA (JP)
SAKIMAE AKIHIRO (JP)

International Classes:

C07C53/128; C07C55/02; C07C55/32; C07C57/13; C07C59/01; C07C59/115; C07C69/34; C07C69/593; C07C69/675; C12P41/00; (IPC1-7): C07C59/115; C07C55/02; C07C69/34; C07C69/593; C07C69/675; C12P41/00

Foreign References:

JPH0347092A	1991-02-28
JPS6467190A	1989-03-13
JPH03236796A	1991-10-22
JPS6427498A	1989-01-30
JPS63245694A	1988-10-12

Other References: