Title:
OBSERVATION DEVICE AND OBSERVATION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/054305
Kind Code:
A1
Abstract:
An observation device 1A comprises a light source 11, a mirror 22, a condensing lens 24, an objective lens 25, a beam splitter 41, an imaging unit 43, and an analysis unit 50. The analysis unit 50 comprises an interference intensity image acquisition unit 51, a first complex amplitude image generation unit 52, a second complex amplitude image generation unit 53, a two-dimensional phase image generation unit 54, a three-dimensional phase image generation unit 55, and a refractive index distribution calculation unit 56. The analysis unit 50 changes the orientation of the reflective surface of the mirror 22 so as to irradiate an observation object S with light from each of a plurality of light irradiation directions, acquires from the imaging unit 43 interference intensity images at a reference position for the respective light irradiation directions, and performs a required process on the basis of the interference intensity images so as to obtain a three-dimensional refractive index distribution of the observation object. This makes it possible to achieve three-dimensional refractive index tomography in which the effect of multiple-scattering light is reduced.
Inventors:
YASUHIKO OSAMU (JP)
TAKEUCHI KOZO (JP)
YAMADA HIDENAO (JP)
TAKEUCHI KOZO (JP)
YAMADA HIDENAO (JP)
Application Number:
PCT/JP2021/002099
Publication Date:
March 17, 2022
Filing Date:
January 21, 2021
Export Citation:
Assignee:
HAMAMATSU PHOTONICS KK (JP)
International Classes:
G02B21/00; G01N21/17; G02B21/36
Domestic Patent References:
| WO2019044336A1 | 2019-03-07 | |||
| WO2020013325A1 | 2020-01-16 |
Foreign References:
| JP2019124679A | 2019-07-25 | |||
| JP2017219826A | 2017-12-14 |
Other References:
SUNGSAM KANG ET AL.: "Imaging deep within a scattering medium using collective accumulation of single-scattered waves", NATURE PHOTONICS, vol. 9, 2015, pages 253 - 258, XP055668096, DOI: 10.1038/nphoton.2015.24
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF:
Previous Patent: GASKET
Next Patent: MODULAR REFRIGERATION DEVICE, AND REFRIGERATOR CONSTITUTING PART OF THIS, AND AIRFLOW DIRECTION CONT...
Next Patent: MODULAR REFRIGERATION DEVICE, AND REFRIGERATOR CONSTITUTING PART OF THIS, AND AIRFLOW DIRECTION CONT...