ONCOLYTIC VACCINIA VIRUS HAVING LONG GENE DELETION

Title:

ONCOLYTIC VACCINIA VIRUS HAVING LONG GENE DELETION

Document Type and Number:

WIPO Patent Application WO/2022/071559

Kind Code:

A1

Abstract:

Provided are: a vaccinia virus which can be proliferated specifically in a cancer cell to injure the cancer cell; and a use of the virus in a cancer therapy.　This vaccinia virus is an oncolytic vaccinia virus in which a region composed of 7000 to 9000 base pairs contained in the genome sequence for the vaccinia virus is deleted so that the vaccinia virus cannot proliferate in a normal cell but can proliferate specifically in a cancer cell to injure the cancer cell specifically.

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Inventors:

NAKAMURA TAKAFUMI (JP)
KUWANO NOZOMI (JP)
NAKATAKE MOTOMU (JP)
KOUNO HIROMICHI (JP)

Application Number:

PCT/JP2021/036371

Publication Date:

April 07, 2022

Filing Date:

October 01, 2021

Export Citation:

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Assignee:

NAT UNIV CORP TOTTORI UNIV (JP)
EVOLVE BIOTHERAPEUTICS CO LTD (JP)

International Classes:

C12N7/00; A61K35/768; A61K39/00; A61K48/00; A61P31/04; A61P31/12; A61P33/02; A61P35/00; A61P37/04; C12N7/01; C12N15/863

Foreign References:

JP2014513938A

2014-06-19

Attorney, Agent or Firm:

HIRAKI & ASSOCIATES (JP)

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