Title:
ONCOLYTIC VIRUS AND APPLICATION THEREOF, AND DRUG FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2021/008269
Kind Code:
A1
Abstract:
Provided are an oncolytic virus and an application thereof, and a drug for treating a cancer. A first regulation element and a second regulation element are inserted into the genome of the oncolytic virus. The first regulation element comprises a cancer cell specific promoter sequence and a first nucleic acid sequence driven by the cancer cell specific promoter to express specific protease in cancer cells; the second regulation element comprises a second nucleic acid sequence for encoding an extracellular traction signal peptide and a third nucleic acid sequence for encoding a specific cleavage site. The oncolytic virus can be replicated in cancer cells with high replication capability to kill host cancer cells, and has reliable safety to non-cancer cells.
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Inventors:
WU ZETANG (CN)
Application Number:
PCT/CN2020/094751
Publication Date:
January 21, 2021
Filing Date:
June 05, 2020
Export Citation:
Assignee:
WU ZETANG (CN)
International Classes:
C12N7/01; A61K35/763; A61K35/768; A61P35/00; C12N15/57
Foreign References:
| CN110669740A | 2020-01-10 | |||
| CN109943538A | 2019-06-28 | |||
| CN1884556A | 2006-12-27 | |||
| CN102051358A | 2011-05-11 | |||
| US20110034368A1 | 2011-02-10 |
Other References:
CAI Z ET AL.: "Targeting strategies of adenovirus-mediated gene therapy and virotherapy for prostate cancer", MOLECULAR MEDICINE REPORTS, vol. 16, no. 5, 30 November 2017 (2017-11-30), pages 6443 - 6458, XP055773449, ISSN: 1791-3004, DOI: 10.3892/mmr.2017.7487
SCIENCE, 1991
See also references of EP 4001405A4
SCIENCE, 1991
See also references of EP 4001405A4
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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