Title:
OPHTHALMIC OIL-IN-WATER TYPE EMULSION WITH STABLE POSITIVE ZETA POTENTIAL
Document Type and Number:
WIPO Patent Application WO2006050838
Kind Code:
A3
Abstract:
An ophthalmic oil-in-water type emulsion, which comprises colloid particles having an oily core surrounded by an interfacial film, said emulsion comprising at least one cationic agent, at least one non ionic surfactant said emulsion having a positive zeta potential and meeting zeta potential stability Test A requirements. Process for making said emulsions. Delivery device selected from the group comprising lenses, ocular patch, implant, insert, said device containing an emulsion according to the invention.
Inventors:
BAGUE SEVERINE (FR)
PHILIPS BETTY (FR)
RABINOVICH-GUILATT LAURA (FR)
LAMBERT GREGORY (FR)
GARRIGUE JEAN-SEBASTIEN (FR)
PHILIPS BETTY (FR)
RABINOVICH-GUILATT LAURA (FR)
LAMBERT GREGORY (FR)
GARRIGUE JEAN-SEBASTIEN (FR)
Application Number:
PCT/EP2005/011650
Publication Date:
November 16, 2006
Filing Date:
October 10, 2005
Export Citation:
Assignee:
NOVAGALI PHARMA SA (FR)
BAGUE SEVERINE (FR)
PHILIPS BETTY (FR)
RABINOVICH-GUILATT LAURA (FR)
LAMBERT GREGORY (FR)
GARRIGUE JEAN-SEBASTIEN (FR)
BAGUE SEVERINE (FR)
PHILIPS BETTY (FR)
RABINOVICH-GUILATT LAURA (FR)
LAMBERT GREGORY (FR)
GARRIGUE JEAN-SEBASTIEN (FR)
International Classes:
A61K9/00; A61K9/107
Domestic Patent References:
| WO2003053405A1 | 2003-07-03 |
Foreign References:
| US20030108626A1 | 2003-06-12 | |||
| US6007826A | 1999-12-28 | |||
| EP0696452A1 | 1996-02-14 | |||
| EP0878197A1 | 1998-11-18 | |||
| EP1611879A1 | 2006-01-04 |
Other References:
CHOI W-J ET AL: "Low toxicity of cationic lipid-based emulsion for gene transfer", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 25, no. 27, 25 February 2004 (2004-02-25), pages 5893 - 5903, XP004511128, ISSN: 0142-9612
OTT G ET AL: "A cationic sub-micron emulsion (MF59/DOTAP) is an effective delivery system for DNA vaccines", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 79, no. 1-3, 19 February 2002 (2002-02-19), pages 1 - 5, XP004340908, ISSN: 0168-3659
OGAWA SATOSHI ET AL: "Production and characterization of O/W emulsions containing cationic droplets stabilized by lecithin-chitosan membranes.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 23 APR 2003, vol. 51, no. 9, 23 April 2003 (2003-04-23), pages 2806 - 2812, XP002323017, ISSN: 0021-8561
TAMILVANAN S ET AL: "The potential of lipid emulsion for ocular delivery of lipophilic drugs", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 58, no. 2, 1 June 2004 (2004-06-01), pages 357 - 368, XP004526318, ISSN: 0939-6411
OTT G ET AL: "A cationic sub-micron emulsion (MF59/DOTAP) is an effective delivery system for DNA vaccines", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 79, no. 1-3, 19 February 2002 (2002-02-19), pages 1 - 5, XP004340908, ISSN: 0168-3659
OGAWA SATOSHI ET AL: "Production and characterization of O/W emulsions containing cationic droplets stabilized by lecithin-chitosan membranes.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 23 APR 2003, vol. 51, no. 9, 23 April 2003 (2003-04-23), pages 2806 - 2812, XP002323017, ISSN: 0021-8561
TAMILVANAN S ET AL: "The potential of lipid emulsion for ocular delivery of lipophilic drugs", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 58, no. 2, 1 June 2004 (2004-06-01), pages 357 - 368, XP004526318, ISSN: 0939-6411
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