Title:
ORAL PHARMACEUTICAL COMPOSITION CONTAINING TERIPARATIDE FOR PREVENTION OR TREATMENT OF OSTEOPOROSIS AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/019246
Kind Code:
A1
Abstract:
The present invention relates to an oral pharmaceutical composition for the prevention and treatment of osteoporosis, comprising an ion-bonded complex consisting of teriparatide, L-lysine-linked deoxycholic acid, deoxycholic acid, and an alkylglycoside type surfactant. With a micelle structure having teriparatide integrated thereinto, the ion-bonded complex containing teriparatide according to the present invention is restrained from being degraded by peptidases the gastrointestinal tract, thus being able to maintain a high dose of the drug and can take advantage of various transmembrane absorption pathways to improve the permeability of the drug, with the ultimate increase of oral bioavailability of the drug teriparatide.
Inventors:
CHANG KWAN YOUNG (KR)
KANG SEO HEE (KR)
SEO YU SEON (KR)
PARK JIN WOO (KR)
KANG SEO HEE (KR)
SEO YU SEON (KR)
PARK JIN WOO (KR)
Application Number:
PCT/KR2023/003019
Publication Date:
January 25, 2024
Filing Date:
March 06, 2023
Export Citation:
Assignee:
ICURE BNP CO LTD (KR)
International Classes:
A61K9/107; A61K9/00; A61K9/08; A61K38/29; A61K47/26; A61K47/28; A61P19/10
Foreign References:
| KR20210137373A | 2021-11-17 | |||
| KR102216578B1 | 2021-02-17 | |||
| KR20010104389A | 2001-11-24 | |||
| US20160017046A1 | 2016-01-21 | |||
| KR20060105735A | 2006-10-11 | |||
| DK1643978U | ||||
| KR20170125793A | 2017-11-15 |
Other References:
SUBEDI, L.: "Enhanced oral absorption of teriparatide with therapeutic potential for management of osteoporosis", JOURNAL OF CONTROLLED RELEASE, vol. 349, 19 July 2022 (2022-07-19), pages 502 - 519, XP093035815, DOI: 10.1016/j.jconrel.2022.07.012
JEON, OK-CHEOL: "Oral delivery of zoledronic acid by non-covalent conjugation with lysine- deoxycholic acid", IN VITRO CHARACTERIZATION AND IN VIVO ANTI-OSTEOPOROTIC EFFICACY IN OVARIECTOMIZED RATS, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 82, 2016, pages 1 - 10, XP029362481, DOI: 10.1016/j.ejps.2015.11.004
"Development of oral teriparatide drug through enhancement of intestinal mucosal absorption of drugs", 1 June 2020, ICURE B&P CO., LTD
JEON, OK-CHEOL: "Oral delivery of zoledronic acid by non-covalent conjugation with lysine- deoxycholic acid", IN VITRO CHARACTERIZATION AND IN VIVO ANTI-OSTEOPOROTIC EFFICACY IN OVARIECTOMIZED RATS, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 82, 2016, pages 1 - 10, XP029362481, DOI: 10.1016/j.ejps.2015.11.004
"Development of oral teriparatide drug through enhancement of intestinal mucosal absorption of drugs", 1 June 2020, ICURE B&P CO., LTD
Attorney, Agent or Firm:
DAWOOL PATENT AND LAW FIRM (KR)
Download PDF: