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Title:
ORAL PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2013/122134
Kind Code:
A1
Abstract:
Provided is an FTD- and TPI-containing oral pharmaceutical composition which can be orally administered and is stable even under high humidity conditions. This oral pharmaceutical composition contains α,α,α-trifluorothymidine and 5-chloro-6-(2-iminopyrrolidine-1-yl) methyl-2,4 (1H, 3H)-pyrimidine dione hydrochloride as the active ingredient, and contains, as an excipient, an additive having an 85% or greater critical relative humidity at 25°C.

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Inventors:
OHNISHI YOSHITO (JP)
Application Number:
PCT/JP2013/053513
Publication Date:
August 22, 2013
Filing Date:
February 14, 2013
Export Citation:
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Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/7072; A61K9/20; A61K9/28; A61K31/513; A61K47/10; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P35/00; A61P43/00
Domestic Patent References:
WO2006080327A12006-08-03
WO1996030346A11996-10-03
WO1996030346A11996-10-03
WO2006080327A12006-08-03
Foreign References:
JP2001131075A2001-05-15
JPH11322604A1999-11-24
JP2005112744A2005-04-28
JP2005314413A2005-11-10
JP2007284390A2007-11-01
Other References:
INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 25, 2004, pages 571 - 578
INVEST NEW DRUGS, vol. 26, no. 5, October 2008 (2008-10-01), pages 445 - 54
See also references of EP 2815753A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
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