Title:
ORAL PREPARATION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/107895
Kind Code:
A1
Abstract:
An oral preparation for treating cell proliferation diseases. The oral preparation comprises hydroxylpropoxyl-β-cyclodextrin and an active component. The active component is KX2-361 or a medicinal salt thereof, and KX2-361 is represented by formula 1. By mixing hydroxylpropoxyl-β-cyclodextrin with KX2-361 or the medicinal salt thereof, an inclusion compound is formed, the solubility of the poorly-soluble drug KX2-361 is greatly improved, and accordingly the drug is prepared into an oral preparation. The oral preparation has good stability, high safety, good absorbability, high bioavailability and economical cost.
Inventors:
SHI SHUIPING (CN)
ZHANG QINGYONG (CN)
ZHAO RONGHUA (CN)
CHEN HUIHONG (CN)
ZENG LUN (CN)
OU DAXIN (CN)
LIU YAN (CN)
ZHANG QINGYONG (CN)
ZHAO RONGHUA (CN)
CHEN HUIHONG (CN)
ZENG LUN (CN)
OU DAXIN (CN)
LIU YAN (CN)
Application Number:
PCT/CN2016/110973
Publication Date:
June 29, 2017
Filing Date:
December 20, 2016
Export Citation:
Assignee:
GUANGZHOU XIANGXUE PHARMACEUTICAL CO LTD (CN)
HANGZHOU CONVERD CO LTD (CN)
HANGZHOU CONVERD CO LTD (CN)
International Classes:
A61K9/00; A61K31/5377; A61P35/00
Domestic Patent References:
| WO2014036426A1 | 2014-03-06 | |||
| WO2006071960A2 | 2006-07-06 |
Foreign References:
| CN103274961A | 2013-09-04 | |||
| CN101687798A | 2010-03-31 |
Other References:
WU PEIYING ET AL.: "Progress in solubilization of insoluble drugs", CHINESE TRADITIONAL PATENT MEDICINE, vol. 27, no. 9, September 2005 (2005-09-01), pages 1126 - 1129
LOFTSSON T; BREWSTER ME: "Pharmaceutical applications of cyclodextrins: basic science and product development", J. PHARM. PHARMACOL., vol. 62, no. 11, November 2010 (2010-11-01), pages 1607 - 21, XP008134527, DOI: doi:10.1111/j.2042-7158.2010.01030.x
"Chinese Pharmacopoeia", 2015
"Chinese Pharmacopoeia", article "First Method, Dissolution and Release Measurement Method"
"Chinese Pharmacopoeia", article "Appendix 0921"
See also references of EP 3395346A4
LOFTSSON T; BREWSTER ME: "Pharmaceutical applications of cyclodextrins: basic science and product development", J. PHARM. PHARMACOL., vol. 62, no. 11, November 2010 (2010-11-01), pages 1607 - 21, XP008134527, DOI: doi:10.1111/j.2042-7158.2010.01030.x
"Chinese Pharmacopoeia", 2015
"Chinese Pharmacopoeia", article "First Method, Dissolution and Release Measurement Method"
"Chinese Pharmacopoeia", article "Appendix 0921"
See also references of EP 3395346A4
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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