DRUG INCLUSION COMPOUND, PREPARATION THEREOF, AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2017/107894

A1

A pharmaceutical composition comprises an active component KX2-361 represented by formula 1 or a medicinal salt thereof and hydroxylpropoxyl-β-cyclodextrin. An inclusion compound is formed by KX2-361 or the medicinal salt thereof and hydroxylpropoxyl-β-cyclodextrin, and the solubility of the poorly-soluble drug KX2-361 is improved. The pharmaceutical composition can be prepared into an intravenous preparation and an oral preparation.

JP2005505491	Pharmaceutical composition for intranasal administration of water-soluble active substance
JP2007045842	GLYCOPEPTIDE PHOSPHONATE DERIVATIVES
WO/2012/044140	ANTI-TUBERCULOSIS PREPARATION IN TABLET FORM AND PROCESS FOR PREPARING SAME

SHI SHUIPING (CN)
ZHANG QINGYONG (CN)
ZHAO RONGHUA (CN)
CHEN HUIHONG (CN)
ZENG LUN (CN)
OU DAXIN (CN)
LIU YAN (CN)

PCT/CN2016/110956

June 29, 2017

December 20, 2016

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GUANGZHOU XIANGXUE PHARMACEUTICAL CO LTD (CN)
HANGZHOU CONVERD CO LTD (CN)

A61K47/40; A61K9/08; A61K9/19; A61K9/20; A61K31/5377; A61P35/00

CN103274961A

2013-09-04

NI, NAN ET AL.: "Solubilization of Hydrophobic Drugs in Liquid Preparations", CHINESE JOURNAL OF NEW DRUGS, vol. 14, no. 11, 30 November 2005 (2005-11-30), pages 1277, XP009511372, ISSN: 1003-3734
LIU, EHU ET AL.: "Research Progress of Hydroxypropyl-P-Cyclodextrin Solubilizing Water- insoluble Drugs", CHINA PHARMACEUTICALS, vol. 16, no. 8, 20 April 2007 (2007-04-20), pages 25 - 26, XP009511926, ISSN: 1006-4931

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