Title:
OSIMERTINIB CO-CRYSTAL, PREPARATION METHOD, AND APPLICATION AS DRUG OR IN PHARMACEUTICAL FORMULATION
Document Type and Number:
WIPO Patent Application WO/2023/098848
Kind Code:
A1
Abstract:
Involved are an osimertinib co-crystal, a preparation method therefor, and an application thereof as a drug or in a pharmaceutical formulation, more particularly for treating non-small cell lung cancer. The co-crystal has good solubility, good stability and process developability and the like; and the preparation method is simple and low in cost, and has an important value for optimization and development of the drug in the future.
Inventors:
LIU XIAOZHONG (CN)
ZHENG HEXIAO (CN)
LI JUN (CN)
JIN QIFENG (CN)
ZHENG HEXIAO (CN)
LI JUN (CN)
JIN QIFENG (CN)
Application Number:
PCT/CN2022/136087
Publication Date:
June 08, 2023
Filing Date:
December 02, 2022
Export Citation:
Assignee:
MEDONCARE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D403/04; A61K31/506; A61P35/00
Foreign References:
| CN113968845A | 2022-01-25 | |||
| CN114075169A | 2022-02-22 | |||
| CN114075170A | 2022-02-22 | |||
| CN114685455A | 2022-07-01 | |||
| CN110283052A | 2019-09-27 | |||
| CN106432231A | 2017-02-22 | |||
| CN107915725A | 2018-04-17 |
Other References:
YICHENG WANG ，, FENG CHENGLIANG, YANG SUQIN, JI MIN: "Recent Research Advances of Pharmaceutical Cocrystals", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 37, no. 3, 31 March 2013 (2013-03-31), pages 120 - 130, XP093068827
YAN XIAO-E, AYAZ PELIN, ZHU SU-JIE, ZHAO PENG, LIANG LING, ZHANG CASEY H., WU YA-CHUANG, LI JE-LUEN, CHOI HWAN GEUN, HUANG XIN, SH: "Structural Basis of AZD9291 Selectivity for EGFR T790M", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 15, 13 August 2020 (2020-08-13), US , pages 8502 - 8511, XP093070944, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00891
YAN XIAO-E, AYAZ PELIN, ZHU SU-JIE, ZHAO PENG, LIANG LING, ZHANG CASEY H., WU YA-CHUANG, LI JE-LUEN, CHOI HWAN GEUN, HUANG XIN, SH: "Structural Basis of AZD9291 Selectivity for EGFR T790M", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 15, 13 August 2020 (2020-08-13), US , pages 8502 - 8511, XP093070944, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00891
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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