Title:
OSTEOGENESIS PROMOTER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/031620
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an osteogenesis promoter that can be administered locally and systemically and that is suitable for clinical application. Provided is an osteogenesis promoter that contains, as an active ingredient, at least one compound selected from the group consisting of phenazopyridine hydrochloride, riluzole hydrochloride, tranilast, rabeprazole, indoprofen, nabumetone, luteolin, leflunomide, lansoprazole, methiazole, thiabendazole, albendazole, tiaprofenic acid, balsalazide sodium salt, and cyclosporin A, or a pharmaceutically acceptable salt thereof. Preferably, rabeprazole or lansoprazole, which are proton pump inhibitors, is used as an active ingredient.
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Inventors:
OHNO KINJI (JP)
ISHIGURO NAOKI (JP)
KITOH HIROSHI (JP)
MISHIMA KENICHI (JP)
ISHIGURO NAOKI (JP)
KITOH HIROSHI (JP)
MISHIMA KENICHI (JP)
Application Number:
PCT/JP2012/071264
Publication Date:
March 07, 2013
Filing Date:
August 23, 2012
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
OHNO KINJI (JP)
ISHIGURO NAOKI (JP)
KITOH HIROSHI (JP)
MISHIMA KENICHI (JP)
OHNO KINJI (JP)
ISHIGURO NAOKI (JP)
KITOH HIROSHI (JP)
MISHIMA KENICHI (JP)
International Classes:
A61K31/44; A61K31/121; A61K31/194; A61K31/196; A61K31/352; A61K31/381; A61K31/4035; A61K31/4184; A61K31/42; A61K31/426; A61K31/427; A61K31/428; A61K31/4439; A61K38/00; A61K45/00; A61P19/08; A61P43/00
Domestic Patent References:
| WO2008016002A1 | 2008-02-07 |
Foreign References:
| JP2008523138A | 2008-07-03 | |||
| JP2001253827A | 2001-09-18 | |||
| JPS5262275A | 1977-05-23 | |||
| JPS54141783A | 1979-11-05 | |||
| JPS646270A | 1989-01-10 |
Other References:
CHUN, HJ. ET AL.: "Effect of acid pump antagonist on differentiation and proliferation of osteoclasts/osteoblasts", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 24, no. SUPP.1, 2009, pages A16, XP008172866
ZHAO, J. ET AL.: "Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2- dependent manner", BIOCHEM BIOPHYS RES COMMUN, vol. 369, no. 2, 2008, pages 444 - 448, XP022551961
YANG, L. ET AL.: "Kaempferol Stimulates Bone Sialoprotein Gene Transcription and New Bone Formation", J CELL BIOCHEM, vol. 110, no. 6, 2010, pages 1342 - 1355, XP055146034
See also references of EP 2749285A4
ZHAO, J. ET AL.: "Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2- dependent manner", BIOCHEM BIOPHYS RES COMMUN, vol. 369, no. 2, 2008, pages 444 - 448, XP022551961
YANG, L. ET AL.: "Kaempferol Stimulates Bone Sialoprotein Gene Transcription and New Bone Formation", J CELL BIOCHEM, vol. 110, no. 6, 2010, pages 1342 - 1355, XP055146034
See also references of EP 2749285A4
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Kanji Hagino (JP)
Kanji Hagino (JP)
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Claims:
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