Title:
OSTEOINDUCTIVE BONE REGENERATION MATERIAL AND PRODUCTION METHOD OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2021/261408
Kind Code:
A1
Abstract:
A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.
Inventors:
LUIS ALVAREZ (US)
YASUTOSHI NISHIKAWA (JP)
HIROYUKI TAIRA (JP)
YASUTOSHI NISHIKAWA (JP)
HIROYUKI TAIRA (JP)
Application Number:
PCT/JP2021/023279
Publication Date:
December 30, 2021
Filing Date:
June 18, 2021
Export Citation:
Assignee:
ORTHOREBIRTH CO LTD (JP)
THERADAPTIVE INC (US)
THERADAPTIVE INC (US)
International Classes:
A61L27/46; A61L27/56; A61L27/58; D01D5/08; D01F1/02; D01F6/62
Domestic Patent References:
| WO2007068489A2 | 2007-06-21 | |||
| WO2017188435A1 | 2017-11-02 |
Foreign References:
| US20180280569A1 | 2018-10-04 | |||
| US8853298B2 | 2014-10-07 | |||
| US10092650B2 | 2018-10-09 | |||
| US20160121024A1 | 2016-05-05 | |||
| US20180280569A1 | 2018-10-04 | |||
| US10329327B2 | 2019-06-25 | |||
| US20180280569A1 | 2018-10-04 | |||
| JP2019036052W | 2019-09-13 |
Other References:
AARON W. JAMES ET AL.: "A review of the Clinical Side Effects of Bone Morphogenetic Protein-2", TISSUE ENG. PART B REV., vol. 22, no. 4, 2016, pages 284 - 297
OBATA ET AL.: "Enhanced in vitro cell activity on silicon-doped vaterite/poly(lactic acid) composites", ACTA BIOMATER., vol. 5, no. 1, 2009, pages 57 - 62, XP025804521, DOI: 10.1016/j.actbio.2008.08.004
ALVAREZ ET AL.: "Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTOPP via Fusion to a High Affinity, Multimeric (3-TCP binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors", PLOS ONE, 29 June 2015 (2015-06-29)
OBATA ET AL.: "Enhanced in vitro cell activity on silicon-doped vaterite/poly(lactic acid) composites", ACTA BIOMATER., vol. 5, no. 1, 2009, pages 57 - 62, XP025804521, DOI: 10.1016/j.actbio.2008.08.004
ALVAREZ ET AL.: "Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTOPP via Fusion to a High Affinity, Multimeric (3-TCP binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors", PLOS ONE, 29 June 2015 (2015-06-29)
Attorney, Agent or Firm:
NINOMIYA Katsuyuki (JP)
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