OXYGENIC HETEROCYCLIC COMPOUNDS - KYOWA HAKKO KOGYO KK

Title:

OXYGENIC HETEROCYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/1998/022455

Kind Code:

A1

Abstract:

Oxygenic heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof, wherein n is an integer of 1 to 4; R?1�, R?2�, R?3� and R?4� are the same or diffrent and each represents hydrogen, optionally substituted lower alkyl, etc.; R?5� represents hydrogen or halogeno; R?6� represents hydroxy or optionally substituted lower alkoxy; D represents (1): -C(R?8�)(R?9�)-X- or bond (2): -Y-ZR?14�; and R?7� represents (1), optionally substituted lower alkyl, optionally substituted cycloalkyl, polycycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aromatic heterocycle, optionally substituted heterocycle, or pyridine N-oxide, (2), (3): -Y-Z-(CH�2?)�m?-N(R?16a�)R?16b�, or (4): -Y-CON(R?17a�)R?17b�.

Inventors:

NAKASATO YOSHISUKE (US)
OHSHIMA ETSUO (JP)
KOIKE RIE (JP)
ICHIMURA MICHIO (JP)
MANABE HARUHIKO (JP)
SATO SOICHIRO (JP)
ISHII HIDEE (JP)
YANAGAWA KOJI (JP)

Application Number:

PCT/JP1997/004211

Publication Date:

May 28, 1998

Filing Date:

November 19, 1997

Export Citation:

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Assignee:

KYOWA HAKKO KOGYO KK (JP)
NAKASATO YOSHISUKE (US)
OHSHIMA ETSUO (JP)
KOIKE RIE (JP)
ICHIMURA MICHIO (JP)
MANABE HARUHIKO (JP)
SATO SOICHIRO (JP)
ISHII HIDEE (JP)
YANAGAWA KOJI (JP)

International Classes:

C07D319/18; C07D405/06; C07D405/12; (IPC1-7): C07D319/18; A61K31/335; C07D405/06; C07D405/12

Domestic Patent References:

WO1996036624A1

1996-11-21

Foreign References:

JPS62223184A	1987-10-01
JPH01175933A	1989-07-12
JPS56108766A	1981-08-28
JPS53132581A	1978-11-18
JPH01207267A	1989-08-21

Other References: