Title:
P21-ACTIVATED KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/103450
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an inhibitor which has excellent inhibitory activity on a p21-activated kinase. The present invention, which has solved the above-mentioned problem, is a p21-activated kinase 1 inhibitor that is characterized by containing, as active ingredients, one or more compounds selected from the group consisting of dehydrokawain compounds, derivatives of dehydrokawain compounds, mimosine, derivatives of mimosine, and cucurbitacin compounds.
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Inventors:
TAWATA SHINKICHI (JP)
NGUYEN CAO QUAN BINH (JP)
TAIRA NOZOMI (JP)
NGUYEN CAO QUAN BINH (JP)
TAIRA NOZOMI (JP)
Application Number:
PCT/JP2014/084514
Publication Date:
June 30, 2016
Filing Date:
December 26, 2014
Export Citation:
Assignee:
BIOSYSTEM CONSULTING LTD COMPANY (JP)
International Classes:
A61K31/366; A61K31/4412; A61K31/575; A61P3/10; A61P9/12; A61P25/28; A61P35/00; A61P43/00
Foreign References:
| JP2014136691A | 2014-07-28 | |||
| JP2014065703A | 2014-04-17 | |||
| JP2012077058A | 2012-04-19 | |||
| JP2013199446A | 2013-10-03 |
Other References:
UPADHYAY,A. ET AL.: "Solid-Phase Synthesis of Mimosine Tetrapeptides and Their Inhibitory Activities on Neuraminidase and Tyrosinase", J. AGRIC. FOOD CHEM., vol. 59, no. 24, 28 December 2011 (2011-12-28), pages 12858 - 12863
SEO,CR. ET AL.: "Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling", FOOD CHEM. TOXICOL., vol. 64, February 2014 (2014-02-01), pages 217 - 224, XP028810458, DOI: doi:10.1016/j.fct.2013.11.040
LIU,T. ET AL.: "Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitive of laryngeal squamous cell carcinoma cells to cisplatin", EUR. J. PHARMACOL., vol. 641, no. 1, 1 September 2010 (2010-09-01), pages 15 - 22, XP027091760
BAR-NUN,N. ET AL.: "CUCURBITACINS-REPRESSORS OF INDUCTION OF LACCASE FORMATION", PHYTOCHEMISTRY, vol. 28, no. 5, 1989, pages 1369 - 1371, XP026621406, DOI: doi:10.1016/S0031-9422(00)97748-3
SEO,CR. ET AL.: "Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling", FOOD CHEM. TOXICOL., vol. 64, February 2014 (2014-02-01), pages 217 - 224, XP028810458, DOI: doi:10.1016/j.fct.2013.11.040
LIU,T. ET AL.: "Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitive of laryngeal squamous cell carcinoma cells to cisplatin", EUR. J. PHARMACOL., vol. 641, no. 1, 1 September 2010 (2010-09-01), pages 15 - 22, XP027091760
BAR-NUN,N. ET AL.: "CUCURBITACINS-REPRESSORS OF INDUCTION OF LACCASE FORMATION", PHYTOCHEMISTRY, vol. 28, no. 5, 1989, pages 1369 - 1371, XP026621406, DOI: doi:10.1016/S0031-9422(00)97748-3
Attorney, Agent or Firm:
The Patent Corporate body of Ono & Co. (JP)
Patent business corporation Ono international patent firm (JP)
Patent business corporation Ono international patent firm (JP)
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