Title:
PROCESS FOR MANUFACTURING d,1- alpha -TOCOPHEROL
Document Type and Number:
WIPO Patent Application WO1998021197
Kind Code:
A3
Abstract:
A process for the manufacture of d,1- alpha -tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol comprises carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine [HN(SO2CF32] or a metal salt thereof of the formula Met [N(SO2CF3)2]n (I), wherein Met signifies a metal atom selected from the group of lithium, boron, magnesium, aluminium, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold and n signifies the corresponding valency (1, 2, 3 or 4) of the metal atom Met, as the catalyst or of a combination of a metal salt of formula (I) and a strong Bronsted acid as the catalyst system in an organic solvent. The product of the process is the most active member of the vitamin E group. 00000
Inventors:
BAAK MARCEL
BONRATH WERNER
PAULING HORST
BONRATH WERNER
PAULING HORST
Application Number:
PCT/EP1997/006227
Publication Date:
July 23, 1998
Filing Date:
November 10, 1997
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
B01J31/02; C07B61/00; C07D311/00; C07D311/72; (IPC1-7): C07D311/00
Foreign References:
| EP0658552A1 | 1995-06-21 | |||
| EP0782993A1 | 1997-07-09 | |||
| EP0364340A1 | 1990-04-18 | |||
| DE19533711A1 | 1996-03-14 |
Other References:
K. ISHIHARA ET AL., SYNLETT, no. 11, November 1996 (1996-11-01), pages 1045 - 6, XP002064088
M. MATSUI ET AL., BULL. CHEM. SOC. JPN., vol. 68, 1995, pages 3569 - 71, XP002064089
PATENT ABSTRACTS OF JAPAN vol. 96, no. 1 31 January 1996 (1996-01-31)
H. KOBAYASHI ET AL., CHEMISTRY LETTERS, 1995, pages 307 - 8, XP002064090
K. MIKAMI ET AL., SYNLETT, February 1996 (1996-02-01), pages 171 - 2, XP002064091
K. ISHIHARA ET AL., SYNLETT, March 1996 (1996-03-01), pages 265 - 6, XP002064092
M. MATSUI ET AL., BULL. CHEM. SOC. JPN., vol. 68, 1995, pages 3569 - 71, XP002064089
PATENT ABSTRACTS OF JAPAN vol. 96, no. 1 31 January 1996 (1996-01-31)
H. KOBAYASHI ET AL., CHEMISTRY LETTERS, 1995, pages 307 - 8, XP002064090
K. MIKAMI ET AL., SYNLETT, February 1996 (1996-02-01), pages 171 - 2, XP002064091
K. ISHIHARA ET AL., SYNLETT, March 1996 (1996-03-01), pages 265 - 6, XP002064092
Download PDF:
Previous Patent: ANTIBIOTIC TKR2648 AND PROCESS FOR PRODUCING THE SAME
Next Patent: PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES
Next Patent: PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES