Phenyl-pyrazole compounds having a herbicidal action are known and are described, for example, in EP-A-O 361 114, US-A-5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254.

It has now been found, surprisingly, that substituted pyridyl-pyrazole derivatives have outstanding herbicidal and growth-inhibiting properties.

The present invention therefore relates to compounds of the formula I in which A is =N- or n13 is 1,2 or 3; W is a group R1 is hydrogen, C1-C4alkyl, C1-C4halogenoalkyl, cyano-C1-C4alkyl, 03- or C4alkenyl, 03- or C4halogenoalkenyl, 03- or C4alkynyl or C3-C6cycloalkyl; R2 is hydrogen, C1-C4alkyl, C1-C4halogenoalkyl, C3-C6alkenyl, C3-C6halogenoalkenyl, C3-C6- alkynyl, C1-C4alkylsulfonyl, C1 -C4halogenoalkylsulfonyl, 02-C4alkenylsulfonyl or C2-C4- halogenoalkenylsulfonyl; R3 is hydrogen, C1-C4alkyl, C1-C4halogenoalkyl, C1-C4hydroxyalkyl, C2-C6alkenyl, C2-C6- halogenoalkenyl, C2-C6alkynyl, halogen, cyano, NH2C(S)-, nitro, OHC- or R18R19N-; R18 and R19 independently of one another are hydrogen, C1-C4alkyl, C1-C4halogenoalkyl, C3-C4alkenyl, C3-C4halogenoalkenyl, C3-C6cycloalkyl, C3-C6alkynyl, C1-C6alkylcarbonyl, C1-C6halogenoalkylcarbonyl, C2-C6alkenylcarbonyl, C2-C6halogenoalkenylcarbonyl, C1-C6- alkylsulfonyl or C1-C6halogenoalkylsulfonyl; n1 is 0,1 or 2; R4 is hydrogen, C,-C4alkyl, C1-C4halogenoalkyl, C3-C6alkenyl, C3-C6halogenoalkenyl, C3-C6- alkynyl or C3-C6cycloalkyl; R5 is hydrogen, halogen, C1-C4alkyl, C1-C4halogenoalkyl, cyano, nitro, amino, NH2C(S)-, C1-C4alkylcarbonyl, C1-C4halogenoalkylcarbonyl, C2-C4alkenylcarbonyl, C2-C4- halogenoalkenylcarbonyl or C2-C4alkynylcarbonyl; R11 is hydrogen, fluorine, chlorine, bromine or methyl; R13 is hydrogen, halogen, cyano, CIS(O)2-, CIC(O)-, nitro, amino, HS-, R20NH- or R20R21N-; R20 and R21 independently of one another are C1-Cealkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6- cycloalkyl, C1-C6halogenoalkyl, C3-C6halogenoalkenyl, C1-C4alkylcarbonyl, C1-C4- halogenoalkylcarbonyl, C1-C4alkylsulfonyl, C1 -C4halogenalkylsulfonyl, benzyl or benzyl which is substituted on the phenyl ring once to three times by halogen, C1-C4alkyl or C,-C4- halogenoalkyl; or R13 is R300-; R30 is hydrogen, C1-C6alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C,-C8- halogenoalkyl, C3-C8halogenoalkenyl, C1-C4alkoxy-C1 -C4alkyl, C3-Csalkenyloxy-C1-C4alkyl , C3-C6alkynyloxy-C1-C4alkyl, C1-C4alkoxy-C1-C4alkoxy-C1-C4alkyl, C1-C4alkylthio-C1-C4alkyl, C1-C8alkoxycarbonyl, C3-C8alkenyloxycarbonyl, benzyloxycarbonyl, phenyl, benzyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl, where these aromatic and heteroaromatic rings mentioned can be unsubstituted or substituted once to three times by halogen, C1-C4alkyl or C1-C4halogenoalkyl; or R30 is R31X1C(O)-C1-C8alkyl- or R3jXC(O) -[C1 -C8alkylene]-; I (C6Hs) R32-N-<BR> <BR> X1 is oxygen, sulfur or # ; R31 is hydrogen, C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C1-C8-halogeno- alkyl, C3-C6halogenoalkenyl, C1-C4alkoxy-C1-C4alkyl, C3-C7alkenyloxy-C1-C4alkyl, C1-C4alkyl- thio-C1-C4alkyl, phenyl, phenyl which is substituted once to three times by halogen, C,-C4alkyl or C,-C4halogenoalkyl, benzyl or benzyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C1-C4halogenoalkyl; R32 is hydrogen, C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl or C,-C8-halogeno- alkyl; or R13 is R33S(O)n2-; n2 is 0,1 or 2; R33 is C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C1-C8halogenolkyl, C3-C8- halogenoalkenyl, C1-C4alkoxy-C1-C4alkyl, C3-C6alkenyloxy-C1-C4alkyl, C1-C4alkylthio-C1-C4- alkyl, phenyl, phenyl which is substituted once to three times by halogen, C,-C4alkyl or C,-C4halogenoalkyl, benzyl or benzyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C1-C4halogenoalkyl, and, if n2 is 0, R33 is hydrogen, C1-C8alkylcarbonyl or R34X2C(O)-; X2 is oxygen, sulfur or R35-N- R34 is hydrogen, C1-C8alkyl, C3-C6alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C1-C8-halogeno- alkyl, C3-C8halogenoalkenyl, C1-C4alkoxy-C1-C4alkyl, C3-C6alkenyloxy-C1-C4alkyl, C1-C4alkyl- thio-C1-C4alkyl, phenyl, phenyl which is substituted once to three times by halogen, C1-C4alkyl or C,-C4halogenoalkyl, benzyl or benzyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C1-C4halogenoalkyl; R35 is hydrogen, C,-C8alkyl or C3-C8alkenyl; or R13 is R36R37NS(O)2-; R36 is hydrogen, C1-C6alkyl, C2-C8alkenyl, C3-C8alkynyl or C3-C6cycloalkyl; R37 is hydrogen, C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C1-C6halogenoalkyl, C,-C4-alkyl- carbonyl, C1-C4halogenoalkylcarbonyl, benzoyl or benzoyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C1-C4halogenoalkyl; R13 is R40C(O)-; R40 is hydrogen, fluorine, chlorine, C,-C8alkyl, C2-C8alkenyl, C2-C8alkynyl, C3-C6cycloalkyl, C1-C8halogenoalkyl, cyano-C1-C4alkyl, C2-C8halogenoalkenyl, C1-C4alkoxy-C1-C4alkyl, C3-C6alkenyloxy-C1-C4alkyl, C1-C4alkylthio-C1-C4alkyl, phenyl, phenyl which is substituted once to three times by halogen, C,-C4alkyl or C,-C4halogenoalkyl, benzyl or benzyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C,-C4- halogenoalkyl; or R13 is R50X3C(O)-; R51-N- R52-O-N-<BR> X3 is oxygen, sulfur, # or # ; R50 is hydrogen, C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C1-C8-halogeno- alkyl, C3-C8halogenoalkenyl, cyano-C1-C4alkyl, C1-C4alkoxy-C1-C4alkyl, C3-C6alkenyloxy- C,-C4alkyl, (oxiranyl)-CH2-, oxetanyl-, C1-C4alkylthio-C1 -C4alkyl, phenyl, phenyl which is substituted once to three times by halogen, C,-C4alkyl or C1-C4halogenoalkyl, benzyl or benzyl which is substituted once to three times on the phenyl ring by halogen, C,-C4alkyl or C1-C4halogenoalkyl, phenyl-C2-C6alkyl, C1-C6alkyl-CO-C1-C4alkyl, c,-c,alkyl-C(O)-[C, -C,alkylene- (C,Hd , R53X4C(O)-C1-C6alkyl, R53X4C(O) - [C -Qalkylene]- (C6H5) or R53X4C(O)-C3-C6cycloalkyl;<BR> R54-N- R55-O-N-<BR> <BR> <BR> X4 oxygen, sulfur, # or # ; R53 is hydrogen, C1-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C3-C6cycloalkyl, C1-C6-halogeno- alkyl, C3-C8halogenoalkenyl, cyano-C1-C4alkyl, C1-C4alkoxy-C1-C4alkyl, C3-C6-alkenyloxy- C,-C4alkyl, (oxiranyl)-CH2-, oxetanyl-, C1-C4alkylthio-C1 -Csalkyl, phenyl, phenyl which is substituted once to three times by halogen, C,-C4alkyl or C,-C4halogenoalkyl, benzyl, benzyl which is substituted once to three times on the phenyl ring by halogen, C1-C4alkyl or C1- C4halogenoalkyl, or phenyl-C2-C6alkyl; R51, R52, R54 and R55 independently of one another are hydrogen, C1-C5alkyl, C3-C8alkenyl, C3-C6alkynyl, C1-C8halogenoalkyl or benzyl; or R13 is B1-C1-C8alkyl, B1-C2-C8alkenyl, B1-C2-C8alkynyl, B1-C1-C8halogenoalkyl, B1-C2-C6halogenoalkenyl, B1-C1-C4alkoxy-C1-C4alkyl, B1-C1-C4alkylthio-C1-C4alkyl or B1-C3-C6-cycloalkyl; B1 is hydrogen, cyano, hydroxyl, C1-C8alkoxy, C3-C6alkenyloxy, R60X5C(O)-, C,-C4- alkylcarbonyl or C1-C4halogenoalkyl carbo nyl ; Xs has the meaning of X4; R60 has the meaning of Rs3; ; or R13 is B2-C(R70)=CH-; B2 is nitro, cyano or R71X6C(O)-; R70 is cyano or RnX7C(O)-; X6 and X7 have the meaning of X4; and R71 and Rn have the meaning of R53, and the pyrazole N-oxides, agrochemically tolerated salts and stereoisomers of these compounds of the formula I, the compounds of the formulae loi, 102, 103 and 104 being excluded: In the abovementioned definitions, halogen is to be understood as meaning iodine and, preferably, fluorine, chlorine and bromine.

The alkyl, alkenyl and alkynyl groups occurring in the substituent definitions can be straight- chain or branched, this also applying to the alkyl, alkenyl and alkynyl moiety of the alkylcarbonyl, alkylcarbamoyl, hydroxyalkyl, cyanoalkyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkylthio, alkylthioalkyl, alkylthio-C(O), alkenylcarbamoyl, alkenylthio-C(O), alkynylthio-C(O), alkylsulfonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylcarbonylalkyl, B,alkyl, B1alkenyl, B1alkynyl, HOC(O)alkyl, phenylalkyl, R53X4C(O)-C1-C6alkyl and R60X5C(O)-C1-C8- alkyl groups.

Alkyl groups are, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, iso-butyl, tert-butyl and the various isomeric pentyl, hexyl, heptyl and octyl radicals. Methyl, ethyl, n-propyl, iso-propyl and n-butyl are preferred.

Examples of alkenyls are vinyl, allyl, methallyl, I -methylvinyl, but-2-en-1 -yl, pentenyl, 2-hexenyl, 3-heptenyl and 4-octenyl, preferably alkenyl radicals having a chain length of 3 to 5 carbon atoms.

Examples of alkynyls are ethynyl, propargyl, 1 -methylpropargyl, 3-butynyl, but-2-yn-1 -yl, 2-methylbutyn-2-yl, but-3-yn-2-yl, 1 -pentynyl, pent-4-yn-1 -yl or 2-hexynyl, preferably alkynyl radicals having a chain length of 2 to 4 carbon atoms.

Halogenoalkyl can be alkyl groups which are substituted once or several times, in particular once to three times, by halogen, halogen being iodine and, in particular, fluorine, chlorine and bromine, for example fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2-chloroethyl, 2,2- dichloroethyl, 2,2,2-trifluoroethyl and 2,2,2-trichloroethyl.

Halogenoalkenyl can be alkenyl groups which are substituted once or several times by halogen, halogen being specifically bromine, iodine and, in particular, fluorine and chlorine, for example 2- and 3-fluoropropenyl, 2- and 3-chloropropenyl, 2- and 3-bromopropenyl, 2,3,3-trifluoropropenyl, 2,3,3-trichloropropenyl, 4,4,4-trifluoro-but-2-en- 1 -yl and 4,4,4- trichloro-but-2-en-1 -yl. Of the alkenyl radicals substituted once, twice or three times by halogen, those which have a chain length of 3 or 4 carbon atoms are preferred. The alkenyl groups can be substituted by halogen on saturated or unsaturated carbon atoms.

Alkylsulfonyl is, for example, methylsulfonyl ethylsulfonyl, propylsulfonyl, iso-propylsulfonyl, n-butylsulfonyl, iso-butylsulfonyl, sec-butylsulfonyl and tert-butylsulfonyl; preferably methylsulfonyl and ethylsulfonyl.

Halogenoalkylsulfonyl is, for example, fluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, chloromethylsulfonyl, trichloromethylsulfonyl, 2-fluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl and 2,2,2-trichloroethylsulfonyl.

Alkenylsulfonyl is, for example, allylsulfonyl, methallylsulfonyl, but-2-en-1 -yl-sulfonyl, pentenylsulfonyl and 2-hexenylsulfonyl.

Halogenoalkenylsulfonyl is, for example, 2- and 3-fluoropropenyl-sulfonyl, 2- and 3- chloropropenyl-sulfonyl, 2- and 3-bromopropenyl-sulfonyl, 2,3,3-trifluoropropenyl-sulfonyl, 2,3,3-trichloropropenyl-sulfonyl, 4,4,4-trifluoro-but-2-en-1 -yl-sulfonyl and 4,4,4-trichloro-but- 2-en-l-yl-sulfonyl.

Cyanoalkyl is, for example, cyanomethyl, cyanoethyl, cyanoeth-1 -yl and cyanopropyl.

Hydroxyalkyl is, for example, hydroxymethyl, 2-hydroxyethyl and 3-hydroxypropyl.

Alkylamino is, for example, methylamino, ethylamino and the isomeric propyl- and butylamino.

Dialkylamino is, for example, dimethylamino, diethylamino and the isomeric dipropyl- and dibutylamino.

Alkenylamino is, for example, allylamino, methallylamino and but-2-en-1-ylamino.

Alkynylamino is, for example, propargylamino and 1 -methylpropargylamino.

Halogenoalkylamino is, for example, chloroethylamino, trifluoroethylamino and 3-chloropropylamino.

Di(halogenoalkyl)amino is, for example di(2-chloroethyl)amino.

Alkylcarbonyl is, in particular, acetyl and propionyl.

Halogenoalkylcarbonyl is, in particular, trifluoroacetyl, trichloroacetyl, 3,3,3-trifluoropropionyl and 3,3,3-trichloropropionyl.

Alkenylcarbonyl is, in particular, vinylcarbonyl, allylcarbonyl, methallylcarbonyl, but-2-en-1- yl-carbonyl, pentenylcarbonyl and 2-hexenylcarbonyl.

Alkynylcarbonyl is, in particular, acetylenecarbonyl, propargylcarbonyl, 1-methylpropargyl- carbonyl, 3-butynylcarbonyl, but-2-yn-1 -yl-carbonyl and pent-4-yn-1 -yl-carbonyl.

Alkenyloxy is, for example, allyloxy, methallyloxy and but-2-en-1 -yloxy.

Alkynyloxy is, for example, propargyloxy and 1-methylpropargyloxy.

Alkoxy-alkyl is, for example, methoxymethyl, methoxyethyl, ethoxymethyl, ethoxyethyl, n-propoxymethyl, n-propoxyethyl, iso-propoxymethyl and iso-propoxyethyl.

Alkenyloxy-alkyl is, for example, allyloxy-alkyl, methallyloxy-alkyl and but-2-en-l -yloxy-alkyl.

Alkynyloxy-alkyl is, for example, propargyloxy-alkyl and 1 -methylpro pargyloxy-al kyl.

Alkoxycarbonyl is, for example, methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, iso- propoxycarbonyl and n-butoxycarbonyl, preferably methoxycarbonyl and ethoxycarbonyl.

Alkenyloxycarbonyl is, for example, allyloxycarbonyl, methallyloxycarbonyl, but-2-en-1 -yl- oxycarbonyl, pentenyloxycarbonyl and 2-hexenyloxycarbonyl.

Alkynyloxycarbonyl is, for example, propargyloxycarbonyl, 3-butynyloxycarbonyl, but-2-yn-1 - yl-oxycarbonyl and 2-methylbutyn-2-yl-oxycarbonyl.

Alkoxyalkoxycarbonyl is, for example, methoxymethoxycarbonyl, ethoxymethoxycarbonyl, ethoxyethoxycarbonyl, propoxymethoxycarbonyl, propoxyethoxycarbonyl, propoxypropoxycarbonyl and butoxyethoxycarbonyl.

Halogenoalkoxy is, for example, fluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2- trifluoroethoxy, 1,1 ,2,2-tetrafluoroethoxy, 2-fluoroethoxy, 2-chloroethoxy and 2,2,2- trichloroethoxy.

The cycloalkyl radicals which are suitable substituents are, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The cycloalkoxycarbonyl radicals which are suitable substituents are, for example, cyclopropoxycarbonyl, cyclobutoxycarbonyl, cyclopentoxycarbonyl and cyclohexyloxycarbony1.

Alkylthio is, for example, methylthio, ethylthio, propylthio and butylthio and branched isomers thereof.

Alkylthioalkyl is, for example, methylthioethyl, ethylthioethyl, methylthiopropyl and ethylthiopropyl.

Halogenoalkylthio-carbonyl is, for example, fluoromethylthio-carbonyl, difluoromethylthio- carbonyl, trifluoromethylthio-carbonyl, 2,2,2-trifluoroethylthio-carbonyl, 1,1,2,2- tetrafluoroethylthio-carbonyl, 2-fluoroethylthio-carbonyl, 2-chloroethylthio-carbonyl and 2,2,2-trichloroethylthio-carbonyl.

Phenyl, benzyl or benzoyl as part of a substituent, for example phenoxy, phenylthio, benzyloxy, benzylthio, phenoxycarbonyl, benzyloxycarbonyl, phenoxycarbonylalkyl, benzyloxycarbonylalkyl or benzylamino, are present in substituted or unsubstituted form.

The substituents can then be in the ortho-, meta- or para-position. Substituents, are, for example, C1-C4alkyl, halogen or C1-C4halogenoalkyl.

Corresponding definitions can also be assigned to the substituents in composite definitions, for example halogenoalkenylcarbonyl, alkenyloxy-alkoxy, alkynyloxy-alkoxy, alkoxy-alkoxy- alkoxy, alkylthio-alkylamino, alkylthio-alkylthio, alkoxy-alkylthio, alkenyloxy-alkylthio, alkenyloxy-alkylamino, R30O-, R40C(O)-, R33S(O)n2-, R34X2C(O)-, R50X3C(O)-, R31X1C(O)- alkyl, R53X4C(O)cycloalkyl, R35R37NS(O)2-, B1alkyl, B1alkenyl, B1alkynyl, B1halogencalkyl, B1halogenoalkenyl, B1alkoxyalkyl, B1alkylthoalkyl, B1cycloalkyl and B2-C(R70)=CH-.

In the definition of R30, the group R3tX1 C (O)-IC, -C,alkylene]- (A6H means that the R3tX,C(O)- substituted C1-Cealkylene chain is additionally substituted by phenyl on one of the 8 carbon atoms, where the phenyl ring can be substituted once to three times by halogen, C,-C4alkyl or C1-C4halogenoalkyl and the alkylene chain can be straight-chain or branched and can be, for example, methylene, ethylene, methylethylene, propylene, 1-methyl-propylene and butylene.

In the definition of R50, the groups Ci CsaI kyI-C(O)-[C1-C4aikyene]- and (C6HJ R53X4C(O) - [C1 -C,alkylene]- (16H5) mean that the C:-C6alkyl-C(O)- or R53X4C(O)-substituted C1-C4- or C,-C6alkylene chain is additionally substituted by phenyl (C6H5) on one of the 4 or, respectively, 6 carbon atoms, where the phenyl ring can be substituted once to three times by halogen, C,-C4alkyl or C1-C4halogenoalkyl and the alkylene chain can be straight-chain or branched and can be, for example, methylene, ethylene, methylethylene, propylene, 1-methyl-propylene and butylene.

In the definitions for cyanoalkyl. alkylcarbonyl, alkenylcarbonyl, halogenoalkenyl-carbonyl, alkynylcarbonyl, alkoxycarbonyl and halogenoalkylcarbonyl, the cyano or, respectively, carbonyl carbon atom is not included in the respective lower and upper carbon number limits stated.

In respect of the group W (W1 to W3), the compounds of the formula I are in general present as mixtures comprising the isomers substituted by the pyridyl group (pyrid) in the 3- and 5-position of the pyrazole ring, for example as isomers IW1 a and IW1 b period R3 Pt R3 (IWla) and ' Nm ( W1 b) 2N%N OR2 1 R N OR2 12 R, for the group W1. The isomer ratio can vary according to the synthesis process.

The invention also relates to the salts which the compounds of the formula I with acid hydrogen, in particular the derivatives with carboxylic acid and sulfonamide groups (for example carboxyl-substituted alkyl, alkylene, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl and cycloalkyl groups and N H2SO2-, alkylS(O)2NH- and halogenoalkylS(0)2NH-substituted pyridyl groups (R13)), can form with bases. These salts are, for example, alkali metal salts, for example sodium and potassium salts; alkaline earth metal salts, for example calcium and magnesium salts; ammonium salts, i.e. unsubstituted ammonium salts and mono- or polysubstituted ammonium salts, for example triethylammonium and methylammonium salts; or salts with other organic bases.

Preferred alkali metal and alkaline earth metal hydroxides as salt4orming agents are, for example, the hydroxides of lithium, sodium, potassium, magnesium or calcium, and in particular those of sodium and potassium.

Examples of amines which are suitable for ammonium salt formation include ammonia and primary, secondary and tertiary C1-C1Balkylamines, Ct-C4hydroxyalkylamines and C2-C4- alkoxyalkylamines, for example methylamine, ethylamine, n-propylamine, iso-propylamine, the four isomeric butylamines, n-amylamine, iso-amylamine, hexylamine, heptylamine, octylamine, nonylamine, decylamine, pentadecylamine, hexadecylamine, heptadecylamine, octadecylamine, methyl-ethylamine, methyl-iso-propylamine, methyl-hexylamine, methyl- nonylamine, methyl-pentadecylamine, methyl-octadecylamine, ethyl-butylamine, ethyl- heptylamine, ethyl-octylamine, hexyl-heptylamine, hexyl-octylamine, dimethylamine, diethylamine, di-n-propylamine, di-iso-propylamine, di-n-butylamine, di-n-amylamine, di-iso- amylamine, dihexylamine, diheptylamine, dioctylamine, ethanolamine, n-propanolamine, iso-propanolamine, N,N-diethanolamine, N-ethylpropanolamine, N-butylethanolamine, allylamine, n-butenyl-2-amine, n-pentenyl-2-amine, 2,3-dimethylbutenyl-2-amine, di-butenyl- 2-amine, n-hexenyl-2-amine, propylenediamine, trimethylamine, triethylamine, tri-n- propylamine, tri-iso-propylamine, tri-n-butylamine, tri-iso-butylamine, tri-sec-butylamine, tri-n-amylamine, methoxyethylamine and ethoxyethylamine; heterocyclic amines, for example pyridine, quinoline, iso-quinoline, morpholine, thiomorpholine, piperidine, pyrrolidine, indoline, quinuclidine and azepine; and primary arylamines, for example, anilines, methoxyanilines, ethoxyanilines, o-, m- and p-toluidines, phenylenediamines, benzidines, naphthylamines and o-, m- and p-chloroanilines; and in particular triethylamine, iso-propylamine and di-iso-propylamine.

The salts of the compounds of the formula I with basic groups, in particular with basic pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl and pyrazolyl rings, or of the derivatives with amino groups, for example alkylamino and dialkylamino groups, in the definition of R3, R5 and R13 are, for example, salts with inorganic and organic acids, for example hydrogen halide acids, such as hydrofluoric acid, hydrochloric acid, hydrobromic acid or hydroiodic acid, and sulfuric acid, phosphoric acid and nitric acid, and organic acids, such as acetic acid, trifluoroacetic acid, trichloroacetic acid, proprionic acid, glycolic acid, thiocyanic acid, citric acid, benzoic acid, oxalic acid, formic acid, benzenesulfonic acid, p-toluenesulfonic acid and methanesulfonic acid.

The possible presence of at least one asymmetric carbon atom in the compounds of the formula I, for example in the substituent R13 = OR30, in which R30 is a branched alkyl, alkenyl, halogenoalkyl or alkoxyalkyl group, or R13 = S(O)n2R331 in which, for example, n2 = 1 and/or R33 is a branched alkyl, alkenyl, halogenoalkyl or alkoxyalkyl group, means that the compounds can occur both in optically active individual isomers and in the form of racemic mixtures. In the present invention, the active compounds of the formula I are to be understood as meaning both the pure optical antipodes and the racemates or diastereomers.

If an aliphatic 0=0 double bond is present, geometric isomerism can occur. The present invention also relates to these isomers.

Preferred compounds of the formula I are those in which R3 is hydrogen, C,-C4alkyl, C,-C4- halogenoalkyl, C2-C6alkenyl, C2-C6halogenoalkenyl, C2-C6alkynyl, halogen, cyano, NH2C(S)-, nitro or Ri8RigN-.

Preferred compounds of the formula I have the formula la in which Wa is a group R1, R2, R3, R4, R5, R11, R13 and n1 are as defined under formula I; and R12 is hydrogen, halogen, C,-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4halogenoalkyl, C2-C4-halogenoalkenyl, nitro, amino, CHO, C1-C4halogenoalkoxy, cyano, C3-C6cycloalkyl, phenoxy, phenoxy which is substituted once to three times by halogen, C,-C4alkyl or C,-C4- halogenoalkyl, benzyloxy or benzyloxy which is substituted once to three times on the phenyl ring by halogen, C1-C4alkyl or Ct-C4halogenoalkyl.

Particularly preferred compounds are those of the formula la in which R3 is methyl, C1-C4- halogenoalkyl, chlorine or bromine. Of these, those compounds in which Wa is the group WI a are especially preferred.

Compounds which are also especially preferred are those of the formula la in which Wa is the group W3a; and R3 is methyl, Ct-C4halogenoalkyl, chlorine or bromine.

Compounds which are likewise especially preferred are those of the formula la in which Wa is the group W3a; and R3 is methyl, Ct-C4halogenoalkyl, chlorine or bromine.

Particularly preferred compounds of the formula la are those in which Wa is the group W3a; and R3 is R18R19N-.

Particularly important compounds of the formula la are those in which Wa is the group W1 a; R1 is C,-C4alkyl; R2 is Ci- or C2halogenoalkyl; R3 is chlorine or bromine; A is =N-; R11 is fluorine, chlorine or bromine; R:2 is halogen; and R13 is hydrogen. Of these, those in which R1 is methyl or ethyl; R2 is halogenomethyl; R3 is chlorine; R11 is fluorine; and R12 is chlorine are particularly important; and in particular, of these compounds, that in which R1 is methyl; and R2 is difluoromethyl is especially important.

The process according to the invention for the preparation of compounds of the formula I is carried out analogously to known processes, as described, for example, in WO 96/01254 and WO 97/00246, and comprises, for the purpose of preparation of those compounds of the formula I in which W is a group (W1); R1, R2, R11, R13, A and nt3 are as defined under formula I; and R3 is hydrogen, halogen, C,-C4alkyl or C1-C4halogenoalkyl, for example reacting a compound of the formula X in which R11, Rt3 and n13 are as defined, in an alcohol of the formula XV R8-OH (XV), in which R5 is C1-C4alkyl, in the presence of a suitable palladium or nickel catalyst, for example palladium bis(triphenylphosphine)dichloride (PdCl2(PPh3)2), and a base, for example triethylamine, under an increased pressure of carbon monoxide to give the compound of the formula Xl in which Re, R11, R13 and n13 are as defined, hydrolysing this under acid or basic conditions to give the corresponding carboxylic acid of the formula XII and converting this with a carboxylic acid halogenating reagent, for example thionyl chloride, phosphorus pentachloride or oxalyl chloride, into the corresponding carboxylic acid halide of the formula XIII in which R11, R13 and n13 are as defined; and Hal is halogen, preferably chlorine, and reacting this in a solvent, for example acetonitrile, in the presence of an alkaline earth metal salt, preferably magnesium chloride, and a base, for example triethylamine, with the malonic acid monoester salt of the formula XVI in which R3 is hydrogen,, C1-C4alkyl or C1-C4halogenoalkyl; M,+ is an alkali metal ion, preferably a potassium ion; and R7 is C,-C4alkoxy, to give the keto ester of the formula Ill in which R3, R7, R11, R13 and n13 are as defined, and cyclizing this in a solvent, for example glacial acetic acid, with the compound of the formula XIV NH2NH-R1 (XIV), in which R1 is as defined under the formula I, to give the compound of the formula Ic in which R1, R3, R11, Rt3 and n13 are as defined, and then, by standard processes, functionalizing, in particular freonizing, the hydroxyl group, according to the definition of R2, if appropriate halogenating the pyrazole ring (R3 halogen), or oxidizing the compound to the corresponding pyridine N-oxide.

All further compounds originating from the scope of the formula I can easily be prepared in an analogous manner, in respect of the build-up of the pyrazole ring, to that described in Preparation Examples H1 to H34, or to that described, for example, in "Methoden der Organischen Chemie" [Methods of organic chemistry] (Houben-Weyl), Volume E 8b, Georg Thieme Verlag Stuttgart, 1994, page 399 et seq.; or in "Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings", Editor R. H. Wiley, Interscience Publishers, John Wiley & Sons, New York, 1967, page 1 et seq.; or to that described in the following patent specifications EP-A-0 361114, US-A-5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254, taking into account the chemical properties of the pyridyl moiety.

A large number of known standard processes are available for the preparation of the pyridylpyrazoles of the formula I substituted on the pyridyl ring, the choice of suitable preparation processes depending on the properties (reactivities) of the substituents in the particular intermediate. Some examples are described in Preparation Examples H1 to H34.

The starting compounds 2,5-dichloro-3-fluoropyridine, 2,3-dichloro-5- trifluoromethylpyridine and 3,5-dichloro-2-acetylpyridine used in Preparation Examples H1, H2 and H11 and the compounds of the formulae X, XIV and XVI are either known or can be prepared by processes analogous to disclosed processes.

For the preparation of the compounds of the formula I, in particular in which W is a group W3; R5 is halogenoalkyl (Example H11); and R1, R3, R,1, R13, A and n13 are as defined under formula I, the compounds of the formula II in which A, R1, R3, R11, R13 and n13 are as defined in claim 1; Ro5 is HOC(O)-, CIC(O)-, (CH3O)(CH3)N-C(O)-, C1-C4alkyloxycarbonyl, NH2C(O)-, OHC-, R6O-N=CH-, HON=CH-, (C1-C4alkoxy)2CH-, C1-C4alkyl-CH(OH), C1-C4halogenoalkyl-CH(OH)-, C2-C4alkenyl- CH(OH)-, C2-C4halogenoalkenyl-CH(OH)- or C2-C4alkynyl-CH(OH)-; and Re is C1-C4alkyl, C1- C4halogenoalkyl, C1-C4alkylcarbonyl, C1-C4halogenoalkylcarbonyl, C1-C4alkylsulfonyl or C1- C4halogenoalkylsulfonyl, are important intermediates.

The compounds of the formula IV are prepared in accordance with EP-A-0 361 114, US-A- 5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254.

For the preparation of the compounds of the formula I in which W is a group (W1); R1, R2, R11, R13, A and n,3 are as defined under formula I; and R3 is hydrogen, halogen, C1-C4alkyl or C1-C4halogenoalkyl, the compounds of the formula Ill in which A, R11, R13 and n13 are as defined under formula I; Re is hydrogen, C1-C4alkyl, halogen or C,-C4halogenoalkyl; and R7 is C1-C4alkoxy, C1- or C2halogenoalkyl or Ci- C4alkoxycarbonyl, the compounds of the formula III01 and 11102 being excluded, are important intermediates.

For the preparation of the compounds of the formula la in which W is a group W3a; R5 is hydrogen; and R1, Re, R11, R13, A and n13 are as defined under formula I, the compounds of the formula IV in which A, R11, R13 and n13 are as defined under formula I; and Re is hydrogen, halogen, C,-C4alkyl or C1-C4halogenoalkyl, are important intermediates.

The compounds of the formula IV are prepared in accordance with EP-A-0 361 114, US-A-5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254.

For the preparation of the compounds of the formula I in which W is a group W3 (W3); Re is hydrogen, C1-C4alkyl or C1-C4halogenoalkyl; Rg is amino; and R1, R11, R13, A and n13 are as defined under formula I; the compounds of the formula V in which A, Rii, R13 and n13 are as defined under formula I; and Re is hydrogen, C1-C4alkyl or C1-C4halogenoalkyl, are important intermediates.

The compounds of the formula V are prepared in accordance with EP-A-0 361114, US-A-5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254.

The intermediates of the formulae 11, III, IV and V are novel. The invention thus also relates to these compounds, excluding the comounds of the formulae III01 and 11102 All further compounds originating from the scope of the formula I can easily be prepared by processes analogous to those according to Preparation Examples H1 to H34, or in a manner analogous to that described in ""Methoden der Organischen Chemie" [Methods of organic chemistry] (Houben-Weyl), Volume E 8b, Georg Thieme Verlag Stuttgart, 1994, page 399 et seq.; ibid, Volume E7B, Georg Thieme Verlag Stuttgart, 1992, page 286 et seq.; in "Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings", Editor R. H. Wiley, Interscience Publishers, John Wiley & Sons, New York, 1967, page 1 et seq.; or in "Comprehensive Heterocyclic Chemistry", Editors A. R. Katritzky and C. W.

Rees, Pergamon Press, Oxford, 1987, or by derivatization by known standard methods, as described, for example, in "Advanced Organic Chemistry", Third Edition, Editor J. March, John Wiley & Sons, New York, 1985; in "Comprehensive Organic Transformations", Editor R. C. Larock, VCH Publishers, Inc., New York, 1989; or in "Comprehensive Organic Functional Group Transformations", Editors A.R. Katritzky, O. Meth-Cohn, C.W. Rees, Pergamon Press, Oxford, 1995, or as described in the following patent specifications EP-A-0 361 114, US-A-5 032 165, WO 92/02509, WO 92/06962, WO 95/33728 and WO 96/01254, taking into consideration the particular chemical reactivities.

The end products of the formula I can be isolated in the customary manner by concentration or evaporation of the solvent and can be purified by recrystallization or trituration of the solid residue in solvents in which they do not dissolve readily, such as ethers, aromatic hydrocarbons or chlorinated hydrocarbons, by distillation or by means of column chromatography and a suitable eluting agent.

The sequence in which certain reactions are advantageously to be carried out in order possibly to avoid secondary reactions is also familiar to the expert.

If no controlled synthesis is carried out for isolation of pure isomers, the product can be obtained as a mixture of two or more isomers. These isomers can be separated by methods known per se.

The compounds of the formula I or compositions comprising them can be used according to the invention by all the application methods customary in agriculture, for example preemergence application, postemergence application and seed dressing, and various methods and techniques, for example controlled release of active substances. For this, the active substance is adsorbed in solution onto mineral granule carriers or polymerized granules (urea/formaldehyde) and dried. If appropriate, a coating which allows the active substance to be released in metered form over a certain period of time can additionally be applied (coated granules).

The compounds of the formula I can be employed in unchanged form, i.e. as they are obtained in the synthesis, but they are preferably processed in a customary manner with the auxiliaries conventionally used in the art of formulation, for example to give emulsifiable concentrates, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granules or microcapsules. The methods of application, such as spraying, atomizing, dusting, wetting, scattering or pouring, in the same way as the nature of the compositions, are chosen according to the required aims and the given circumstances.

The formulations, i.e. the compositions, formulations or preparations comprising the active substance of the formula I or at least one active substance of the formula I and as a rule one or more solid or liquid formulation auxiliaries, are prepared in a known manner, for example by intimate mixing and/or grinding of the active substances with the formulation auxiliaries, for example solvents or solid carriers. Surface-active compounds (surfactants) can furthermore additionally be used during preparation of the formulations.

Possible solvents are: aromatic hydrocarbons, preferably fractions C8 to Ct2, for example xylene mixtures or substituted naphthalenes, phthalic acid esters, such as dibutyl or dioctyl phthalate, aliphatic hydrocarbons, such as cyclohexane or paraffins, alcohols and glycols, and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl or -ethyl ether, ketones, such as cyclohexanone, strongly polar solvents, such as N-methyl-2- pyrrolidone, dimethyl sulfoxide or N,N-dimethylformamide, and epoxidized or non- epoxidized vegetable oils, such as epoxidized coconut oil or soya oil; or water.

Solid carriers which are as a rule used, for example for dusts and disposable powders, are natural rock powders, such as calcite, talc, kaolin, montmorillonite or attapulgite. To improve the physical properties of the formulation, highly disperse silicic acid or highly disperse absorbent polymers can also be added. Granular, adsorptive granule carriers are porous types, for example pumice, crushed brick, sepiolite or bentonite, and non-sorptive carrier materials can be, for example, calcite or sand. A large number of pregranulated materials of inorganic or organic nature, such as, in particular, dolomite or comminuted plant residues, can also be used.

Possible surface-active compounds are nonionic, cationic and/or anionic surfactants and surfactant mixtures having good emulsifying, dispersing and wetting properties, depending on the nature of the active substance of the formula I to be formulated.

Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds.

Possible soaps are the alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts of higher fatty acids (CiO'C22), for example the Na or K salts of oleic or stearic acid, or of naturally occurring fatty acid mixtures, which can be obtained, for example, from coconut oil or tallow oil. Fatty acid methyl-taurine salts may furthermore also be mentioned.

More often, however, so-called synthetic surfactants are used, in particular fatty alcohol sulfonates, fatty alcohol sulfates, sulfonated benzimidazole derivatives or alkylarylsulfonates.

The fatty alcohol sulfonates or sulfates are as a rule in the form of alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts and contain an alkyl radical having 8 to 22 C atoms, alkyl also including the alkyl moiety of acyl radicals, for example the Na or Ca salt of ligninsulfonic acid, of dodecylsulfuric acid ester or of a fatty alcohol sulfate mixture prepared from naturally occurring fatty acids. These also include the salts of sulfuric acid esters and sulfonic acids of fatty alcohol/ethylene oxide adducts. The sulfonated benzimidazole derivatives preferably contain 2 sulfonic acid groups and a fatty acid radical having 8-22 C atoms. Alkylarylsulfonates are, for example, the Na, Ca or triethanolamine salts of dodecylbenzenesulfonic acid, of dibutylnaphthalenesulfonic acid or of a naphthalenesulfonic acid/formaldehyde condensation product.

Corresponding phosphates, for example salts of the phosphoric acid ester of a p-nonylphenol-(4-1 4)-ethylene oxide adduct, or phospholipids can furthermore also be used.

Nonionic surfactants are, in particular, polyglycol ether derivatives of aliphatic or cycloaliphatic alcohols, saturated or unsaturated fatty acids and alkylphenols, which can contain 3 to 30 glycol ether groups and 8 to 20 carbon atoms in the (aliphatic) hydrocarbon radical and 6 to 18 carbon atoms in the alkyl radical of the alkylphenols.

Further suitable nonionic surfactants are the water-soluble adducts, containing 20 to 250 ethylene glycol ether groups and 10 to 100 propylene glycol ether groups, of polyethylene oxide on polypropylene glycol, ethylenediaminopolypropylene glycol and alkylpolypropylene glycol having 1 to 10 carbon atoms in the alkyl chain. The compounds mentioned usually contain 1 to 5 ethylene glycol units per propylene glycol unit.

Examples of non ionic surfactants are nonylphenolpolyethoxyethanols, castor oil polyglycol ethers, polypropylene/polyethylene oxide adducts, tributylphenoxypolyethoxyethanol, polyethylene glycol and octylphenoxypolyethoxyethanol.

Fatty acid esters of polyoxyethylene sorbitan, such as polyoxyethylene sorbitan trioleate, can furthermore also be used.

The cationic surfactants are, in particular, quaternary ammonium salts which contain at least one alkyl radical having 8 to 22 C atoms as N substituents, and lower, halogenated or non- halogenated alkyl, benzyl or lower hydroxyalkyl radicals as further substituents. The salts are preferably present as halides, methyl sulfates or ethyl sulfates, for example stearyltrimethylammonium chloride or benzyldi(2-chloroethyl)ethylammonium bromide.

The surfactants conventionally used in the art of formulation and which can also be used in the compositions according to the invention are described, inter alia, in "Mc Cutcheon's Detergents and Emulsifiers Annual" MC Publishing Corp., Ridgewood New Jersey, 1981, Stache, H., "Tensid-Taschenbuch" [Surfactant handbook], Carl Hanser Verlag, Munich/Vienna, 1981 and M. and J. Ash, "Encyclopedia of Surfactants", Vol 1-111, Chemical Publishing Co., New York, 1980-81.

The herbicidal formulations as a rule comprise 0.1 to 99% by weight, in particular 0.1 to 95% by weight, of herbicide, 1 to 99.9% by weight, in particular 5 to 99.8% by weight, of a solid or liquid formulation auxiliary and 0 to 25% by weight, in particular 0.1 to 25% by weight, of a surfactant.

While concentrated compositions are rather preferred as commercial goods, the end user as a rule uses dilute compositions.

The compositions can also comprise further additives, such as stabilizers, for example epoxidized or non-epoxidized vegetable oils (epoxidized coconut oil, rapeseed oil or soya oil), defoamers, for example silicone oil, preservatives, viscosity regulators, binders, tackifiers and fertilizers or other active substances.

In particular, preferred formulations have the following compositions: (% = per cent by weight) Emulsifiable concentrates: Active substance: 1 to 90%, preferably 5 to 50% Surface-active agent: 5 to 30%, preferably 10 to 20% Solvent: 15 to 94%, preferably 70 to 85% Dusts: Active substance: 0.1 to 50%, preferably 0.1 to 1% Solid carrier: 99.9 to 90%, preferably 999 to 99% SusDension concentrates: Active substance: 5 to 75%, preferably 10 to 50% Water: 94 to 24%, preferably 88 to 30% Surface-active agent: 1 to 40%, preferably 2 to 30% Wettable powders: Active substance: 0.5 to 90%, preferably 1 to 80% Surface-active agent: 0.5 to 20%, preferably 1 to 15% Solid carrier material: 5 to 95%, preferably 15 to 90% Granules: Active substance: 0.1 to 30%, preferably 0.1 to 15% Solid carrier: 99.5 to 70%, preferably 97 to 85% The active substances of the formula I, either as a mixture comprising the isomers la and Ib or as pure isomers la or Ib, can as a rule be employed successfully on plants or their environment with rates of application of 0.001 to 4 kg/ha, in particular 0.005 to 2 kg/ha. The dosage required for the desired action can be determined by tests. It depends on the nature of the action, the stage of development of the crop plants and of the weeds and on the application (location, time, method), and can vary within wide limits, depending on these parameters.

The compounds of the formula I and as a rule in particular the isomers of the formula la are distinguished by herbicidal and growth-inhibiting properties which enable them to be employed in crops of useful plants, in particular in cereals, cotton, soya, sugarbeet, sugarcane, plantations, oilseed rape, maize and rice, and for non-selective weed control ('Total Vegetation Management', TVM).

Crops are also to be understood as meaning those which have been rendered tolerant to herbicides or classes of herbicides by conventional breeding or genetic engineering methods. The weeds to be controlled can be both mono- and dicotyledon weeds, for example Stellaria, Nasturtium, Agrostis, Digitaria, Avena, Setaria, Sinapis, Lolium, Solanum, Phaseolus, Echinochloa, Scirpus, Monochoria, Sagittaria, Bromus, Alopecurus, Sorghum halepense, Rottboellia, Cyperus, Abutilon, Sida, Xanthium, Amaranthus, Chenopodium, Ipomoea, Chrysanthemum, Galium, Viola and Veronica.

The following examples illustrate the invention further without limiting it.

preparation examples: Example H1: Ethvl 3-fluoro-5-chloro-2-Dvridinecarboxvlate An autoclave is loaded with 31.4 g of 2,5-dichloro-3-fluoropyridine, 400 ml of dry ethanol, 27.8 ml of triethylamine and 3.5 g of palladium bis(triphenylphosphine) dichloride (PdCI2(PPh3)2), and 180 bar of carbon monoxide are then forced in. The mixture is then kept at 90"C for 4 days. After cooling and letting down the pressure, a further 3.5 g of PdC12(PPh3)2 are added, 130 bar of carbon monoxide are forced in and the temperature is kept at 90"C for 3 days. Thereafter, the mixture is cooled to 25"C, the pressure is let down and the autoclave is unloaded. After the mixture has been concentrated in vacua, the residue is adsorbed onto silica gel from ethyl acetate. After the silica gel has been applied to a flash chromatography column (silica gel), the column is eluted with n-hexane/ethyl acetate 3/1. 24.3 g of the desired target compound of melting point 48-50°C are obtained.

Example H2: Ethyl 3-chloro-5-trifluoromethvl-2-Dvridinecarboxvlate An autoclave is loaded with 200 g of 2,3-dichloro-5-trifluoromethylpyridine, 1.85 1 of ethanol, 260 ml of triethylamine and 6.5 g of palladium bis(triphenylphosphine)dichloride (PdC12(PPh3)2). 110 bar of carbon monoxide are then forced in at 25"C and the mixture is kept at 110"C for 24 hours. After cooling to 25"C, the crude mixture is concentrated to a thick slurry, which is then partitioned between dilute sodium chloride solution and ethyl acetate. After extraction by shaking and separation of the phases, the ethyl acetate phase is washed with water, dried over sodium sulfate and concentrated to dryness. The crude product is distilled under a high vacuum at 0.035 mbar. 200 g of the desired product are obtained as a yellow oil of boiling point 67-70°C/0.035 mbar (yield 85% of theory) Example H3: 3-Chloro-5-trifluoromethyl-2-pyridinecarboxviic acid 423 g of ethyl 3-chloro-5-trifluoromethyl-2-pyridinecarboxylate (Example H2) is initially introduced into a mixture of 800 ml of water and 160 ml of ethanol. 800 ml of a 2N sodium hydroxide solution are added dropwise at a temperature below 35"C. After 3 hours, the mixture is washed twice with methylene chloride and then rendered acid with an excess of concentrated hydrochloric acid, while cooling in an ice-bath. The slurry formed is filtered and the solid is washed with water and dried in vacuo. 318 g of the desired product are obtained as a white solid of melting point 135"C (decomposition).

Examole H4: 3-Fluoro-5-chloro-2-pyridinecarboxylic acid 70 g of ethyl 3-fluoro-5-chloro-2-pyridinecarboxylate (Example H1) are initially introduced into 105 ml of dimethyl sulfoxide (DMSO). 230 ml of a 2N sodium hydroxide solution are added dropwise at 40"C in the course of 30 minutes. The resulting yellow suspension is introduced into a mixture of 2 1 of ice-water and 400 ml of 2N hydrochloric acid. After subsequently stirring for 20 minutes, the mixture is filtered and the material on the filter is washed twice with water. 56.4 g of the desired target compound are obtained as a white solid.

'H-NMR (DMSO-D6): 13.79 ppm (broad signal, 1H); 8.60 ppm (d, 1H); 8.27 ppm (dxd, 1H).

Example H5: 3-Chloro-5-trifluoromethvl-2-pvridinecarbonyl chloride 89.3 g of 3-chloro-5-trifluoromethyl-2-pyridinecarboxylic acid (Example H3) are slowly heated to reflux temperature together with 60 ml of thionyl chloride and the mixture is then subsequently stirred at this temperature for 4 hours. Thereafter, it is cooled to 25"C and concentrated to dryness in vacuo. Toluene is added twice more and the mixture is concentrated again to dryness. 94.0 g of the desired product are obtained as a yellow residue.

rH-NMR (CDC13): 8.91 ppm (d, 1H); 8.13 ppm (d, 1H).

Example H6: 3-Fluoro-5-chloro-2-pvridinecarbonvl chloride 71.38 g of 3-fluoro-5-chloro-2-pyridinecarboxylic acid is initially introduced into a round- bottomed flask and heated up to 90"C. 59 ml of thionyl chloride are added dropwise from a dropping funnel in the course of 30 minutes, and the gas formed is passed into sodium hydroxide solution. The mixture is subsequently stirred at 10000 for a further 5 hours. The thionyl chloride is then distilled off under normal pressure. After addition of 50 ml of dry toluene, 20 ml thereof are distilled off. The solution thus obtained is poured onto 200 ml of n-hexane and the mixture is stirred overnight. After cooling in an ice-bath, the mixture is filtered and the material on the filter is washed twice with n-hexane. 68.7 g of the desired compound are obtained as a brown solid.

'H-NMR (CDC13): 8.60 ppm (d, 1H); 7.69 ppm (dxd, 1H).

Example H7: 3-Fluoro-5-chloro-2-ovridinecarboxamide 4.0 g of 3-fluoro-5-chloro-2-pyridinecarbonyl chloride (Example H6) are added in portions to a stirred mixture of 26 ml of 30% aqueous ammonia solution and 4 ml of tetrahydrofuran.

The yellowish suspension is subsequently stirred for 4 hours and filtered and the material on the filter is washed with water and n-hexane. After drying in vacuo at 40°C,1.34 g of the desired compound are obtained as a white solid of melting point 162-164"C.

The combined aqueous phases are extracted with ethyl acetate. After the organic phase has been washed and dried, it is filtered and the filtrate is concentrated. A further 6.25 g of the desired target compound are isolated in this manner.

ExamDle H8: 3-Fluoro-5-chloro-2-cvanopvrid ine 1.39 g of 3-fluoro-5-chloro-2-pyridinecarboxamide (Example H7) are initially introduced into 8 ml of absolute dioxane, and 1.3 ml of dry pyridine are added. 1.30 ml of trifluoroacetic anhydride are slowly added with a syringe, while stirring and cooling in an ice-bath, and the mixture is subsequently stirred for 30 minutes. The resulting reaction mixture is poured onto 1 N hydrochloric acid at 25"C and extracted with diethyl ether. The ether phase is washed with dilute hydrochloric acid, water, dilute sodium bicarbonate solution and water. After drying over sodium sulfate, the mixture is filtered and the filtrate is concentrated to dryness.

1.14 g of the desired compound are obtained as a slightly violet-coloured solid of melting point 72-73°C.

Example H9: 3-Chloro-5-trifluoromethvl-2-acetylDyridine 55.3 ml of dimethyl malonate are stirred together with 129 ml of triethylamine and 24.9 g of anhydrous magnesium chloride in 250 ml of dry toluene for 2 hours. Under an exothermic reaction, the reaction temperature rises to 45"C. 94.0 g of 3-chloro-5-trifluoromethyl-2- pyridinecarbonyl chloride (Example H5) in 150 ml of toluene are added dropwise at 25"C and the reaction mixture is stirred further overnight. An excess of concentrated hydrochloric acid is then added dropwise, and the mixture is diluted with water and extracted with ethyl acetate. The organic phase is washed with brine, dried over sodium sulfate, filtered and concentrated. 142 9 of a red oil are obtained, and the oil is slowly introduced into a mixture of 20 ml of water and 400 ml of dimethyl sulfoxide, which is kept under gentle reflux with the aid of an oil-bath of 15000. When no further evolution of gas can be detected, water is added and the mixture is extracted with ether. The combined ether phases are washed with water, dried over sodium sulfate, filtered and concentrated. The residue is purified by means of column chromatography (silica gel; eluting agent: n-hexane/ethyl acetate 15/1 (v/v)). 61 g of the desired product are obtained as a yellow oil (70% of theory).

'H-NMR (CDC13): 8.81 ppm (d, 1H); 8.05 ppm (d, 1H); 2.72 ppm (s, 3H).

Example H10: 1-(3-Chloro-5-trifluoromethyl-2-pyridyl)-3-dimethylamino-2-p ropen-1-one 5.0 g of 3-chloro-5-trifluoromethyl-2-acetylpyridine (Example H9) are initially introduced into 30 ml of toluene, and 3.60 ml of N,N-dimethylformamide dimethyl acetal are added. The yellow solution formed is stirred overnight at 10000. After cooling to 25°C, it is concentrated to dryness in vacuo. 6.17 g of the desired target compound are obtained as a dark yellow oil, which later solidifies.

1H-NMR (CDCl3): 8.74 ppm (d, 1H); 7.98 ppm (d, 1H); 7.92 ppm (broad signal, 1H); 5.54 ppm (broad dl H); 3.17 ppm (broad signal, 3H); 2.94 ppm (broad signal, 3H).

Example H11: 3-(3,5-Dichloro-2-pyridyl)-5-trifluoromethyl-[1 H1-ovrazole (Compound No. 1117.052) 15.8 g of 3,5-dichloro-2-acetylpyridine are initially introduced into 125 ml of absolute ether together with 12.0 ml of ethyl trifluoroacetate. The mixture is cooled with an ice-bath, while stirring, and 46.6 ml of a 21% sodium ethylate solution in ethanol are added dropwise.

Thereafter, the ice-bath is removed and the mixture is subsequently stirred overnight at 25°C. After the reaction mixture has been cooled in an ice-bath and 7.5 ml of glacial acetic acid have been added dropwise, the mixture is concentrated in vacuo. 39.0 g of 1-(3,5- dichloro-2-pyridyl)-3-trifluoromethyl-propane-1 3-dione, which can be used directly for the following cyclization step, are obtained.

39.0 9 of 1-(3,5-dichloro-2-pyridyl)-3-trifluoromethyl-propane-1,3-dio ne (Compound No. 1114.052) are initially introduced into ethanol, and 4.85 ml of hydrazine hydrate are slowly added. The reaction mixture is then heated to reflux, while stirring. After 1 hour, it is concentrated to dryness in vacuo and the residue is partitioned between dilute sodium bicarbonate solution and ethyl acetate. After extraction by shaking and separation of the phases, the organic phase is washed with brine, dried over sodium sulfate, filtered and concentrated to dryness.

22.25 g of a yellow oil are obtained, and this is purified by means of flash chromatography (silica gel, eluting agent: n-hexane/ethyl acetate 4/1 (v/v)). 15.0 g of the desired product are obtained as a yellow solid.

'H-NMR (DMSO-D6): 8.81 ppm (m, 1H); 8.64 ppm (m, 1H); 8.26 ppm (m, IH); 7.45 ppm (broad signal, 1 H).

Example H12: 3-(3,5-Dichloro-2-pyridyl)-5-trifluoromethyl-1-methyl-[1H]-p yrazole and 5-(3,5-dichloro-2-pyridyl)-3-trifluoromethyl-1-methyl-[1H]-p yrazole (Compound No. 1115.052) and 8.88 9 of 3-(3,5-dichloro-2-pyridyl)-5-trifluoromethyl-[1 H]-pyrazole (Example H11) are initially introduced into 35 ml of N-methylpyrrolidone. After addition of 13.0 g of potassium carbonate, the mixture is stirred and heated up to 55°C. 2.36 ml of methyl iodide in 5.0 ml of N-methylpyrrolidone are then slowly added dropwise. After the mixture has been subsequently stirred for 2 hours, diethyl ether and water are added, the mixture is extracted by shaking and the organic phase is separated off. The ether phase which has been separated off is washed with brine, dried over sodium sulfate, filtered and concentrated.

The crude product is purified by means of flash chromatography (silica gel; eluting agent: toluene/ethyl acetate 100/1). First, 3.96 g of the isomeric 5-pyridylpyrazole (yield 42%) are isolated as a yellow oil, and then 1.96 9 of the 3-pyridylpyrazole (yield 21%) are isolated as a yellow solid. The Rf values of the two isomeric 3- and 5-pyridylpyrazoles are as follows on silica gel 60 F254 with toluene/ethyl acetate 30/1 as the eluting agent (UV): Rf value 5-pyridylpyrazole: 0.50 Rf value 3-pyridylpyrazole: 0.35 Example H13: 3-(3,5-dichloro-2-pyridyl)-4-chloro-5-trifluoromethyl-1-meth yl-[1H]-pyrazole (Compound No. 14.243) 2.0 g of 3-(3,5-dichloro-2-pyridyl)-5-trifluoromethyl-1 -methyl-[l H]-pyrazole (Example H12) are initially introduced into glacial acetic acid at 40"C, and chlorine gas is passed slowly over the solution, while stirring. The reaction can be monitored analytically by means of thin layer chromatography (silica gel 60 F254, eluting agent: n-hexane/ethyl acetate 4/1, UV).

When no further starting material can be detected, the glacial acetic acid is removed in vacuo and the residue is partitioned between dilute aqueous sodium hydroxide solution and ethyl acetate. After extraction by shaking, the organic phase which has been separated off is washed with brine, dried over sodium sulfate, filtered and concentrated. The yellow oil is purified by means of flash chromatography (silica gel, eluting agent: n-hexane/ethyl acetate 5/1). 1.6 g of the desired compound are obtained as a yellow oil (70% of theory).

'H-NMR (DMSO-D6): 8.80 ppm (d, 1H), 8.48 ppm (d, 1H), 4.11 ppm (s, 3H) The isomeric 5-pyridylpyrazole is also obtained analogously in a 90% yield (crude).

'H-NMR (CDC13): 8.66 ppm (d, 1H); 7.95 ppm (d, IH); 3.83 ppm (s, 3H).

Exampel H14: 3-(3-Fluoro-5-chloro-2-pyridyl)-5-hydroxy-1-methyl-[1H]-pyra zole (Compound No.1,08.035) 110.6 g of malonic acid monomethyl ester 0 potassium salt are initially introduced into 500 ml of absolute acetonitrile. The mixture is cooled in an ice-bath, while stirring, and 109 ml of triethylamine are added dropwise. 84.3 g of anhydrous magnesium chloride are then added. A mild exothermic reaction is observed. After removal of the ice-bath, the mixture is subsequently stirred at 25°C for 2 hours. After renewed cooling in the ice-bath, 68.7 9 of 3-fluoro-5-chloro-2-pyridinecarbonyl chloride (Example H6), in several portions, and 300 ml of absolute acetonitrile are added. A thick slurry gradually forms. The cooling bath is removed and the mixture is subsequently stirred for 5 hours. Thereafter, the reaction mixture is poured onto 3 1 of ice-water and 200 ml of concentrated hydrochloric acid, subsequently stirred for 15 minutes and extracted with ethyl acetate. The organic phase is washed with water and brine, dried over sodium sulfate, filtered and concentrated to dryness in vacuo. 110 g of a brown oil, which is used directly for the next reaction stage, are obtained.

For this next stage, the brown oil obtained above is introduced at 25°C into a solution of 20.5 ml of methylhydrazine in 300 ml of glacial acetic acid and the mixture is then stirred at 85°C for 2 hours. The brown suspension formed is introduced, after cooling to 25°C, into 2.5 1 of ice-water in portions, the mixture is stirred for 1 hour and filtered and the solid is washed with water and n-hexane. After drying at 60°C in vacuo, 65.8 g of the desired title compound of melting point 195-199°C are obtained.

ExamPle H15: 3-(3-Fluoro-5-chloro-2-ovridvl)-5-difluoromethoxy-1 -methyl-Fl H1-pvrazole (Compound No.1107.035) 46.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-hydroxy-1-methyl-[1 H]-pyrazole (Example H14) and 84 g of potassium carbonate are initially introduced into 250 ml of dry dimethylformamide and the mixture is heated up to 85"C. Freon 22 (chlorodifluoromethane) is then passed in over a period of 2 hours, with thorough stirring. TLC analysis of a worked- up sample (silica gel 60 F254; n-hexane/ethyl acetate/glacial acetic acid 20/20/1, UV) shows that no further starting material is present. The reaction mixture is partitioned between water and diethyl ether (foaming on addition of water). After extraction by shaking and separation of the phases, the ether phase is washed twice with water and once with brine. After the organic phase has been dried over sodium sulfate and filtered, the filtrate is concentrated in vacuo and the residue is purified by means of flash chromatography (silica gel; eluting agent: n-hexane/ethyl acetate 2/1 (v/v)). 22.0 g of the desired title compound are obtained as a pale yellow solid.

'H-NMR (CDC13): 8.51 ppm (broad signal, 1H); 7.56 ppm (dxd, 1 H); 6.61 ppm (t, 1H); 6.53 ppm (d, 1H); 3.89 ppm (s, 3H).

Example H16: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-chloro-5-difluoromethoxy-1 -methyl-[1H]- Dvrazole (Compound No. 11.002) 17.92 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-difluoromethoxy-1-methyl-[ 1H]-pyrazole (Example H15) are initially introduced into 60 ml of glacial acetic acid together with 10.6 g of sodium acetate. The mixture is heated up to 60"C, while stirring, and a saturated solution of chlorine in glacial acetic acid is added until TLC analysis of a worked-up sample shows a complete conversion (silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 2/1; UV; Rf value of the starting material 0.34; Rf value of the product 0.48). The mixture is then concentrated to dryness in vacuo and the resulting residue is partitioned between sodium bicarbonate solution and ethyl acetate. The organic phase is washed with brine, dried over sodium sulfate, filtered and evaporated to dryness in vacuo. 19.8 g of the desired target compound (pure according to TLC) are obtained. Melting point 95-96"C.

Example H18: 3-(5-Chloro-2-pyridyl-N-oxide)-4-chloro-5-trifluoromethyl-1- methyl-[1H]- Dvrazole (Compound No. ls3.001) 6.82 g of 3-(5-chloro-2-pyridyl)-4-chloro-5-trifluoromethyl-1-methyl-[ 1 H]-pyrazole are initially introduced into 30 ml of methylene chloride at 25°C. 7.23 g of m-chloroperbenzoic acid are added, while stirring. After 48 hours, a further 2.50 g of m-chloroperbenzoic acid are added.

After a further 24 hours, the reaction mixture is taken up in ethyl acetate and extracted twice with dilute sodium hydroxide solution, rinsed with brine, dried over sodium sulfate and concentrated. The residue is then chromatographed (silica gel; eluting agent: n-hexane/ethyl acetate 1/1 (v/v)). 6.31 g of the desired compound are isolated as a white solid.

'H-NMR (DMSO-D6): 8.75 ppm (d, IH); 7.66 ppm (d, 1H); 7.59 ppm (dxd, 1H); 4.08 ppm (s, 3H).

Starting from the isomeric 5-(5-chloro-2-pyridyl)-4-chloro-3-trifluoromethyl-1 -methyl-[1 H]- pyrazole, the isomeric 5-(5-chloro-2-pyridyl-N-oxide)-4-chloro-3-trifluoromethyl- 1-methyl- [1 H]-pyrazole can be obtained in a 70% yield Example H19: 3-(3-Fluoro-5-chloro-2-pyridyl-N-oxide)-4-chloro-5-difluorom ethoxy-1-methyl- [1H]-pyrazole (Compound No. I68.002) 0.57 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-chloro-5-difluoromethoxy-1 -methyl-[1 H]-pyrazole (Example H16) is initially introduced into 5 ml of methylene chloride, and 0.63 g of a 55% m-chloroperbenzoic acid is added. After the crude mixture has been stirred at 25°C for 4 days, it is taken up in ethyl acetate and washed successively with sodium bicarbonate solution, water and brine. After drying over sodium sulfate and filtering, the filtrate is concentrated and the residue is purified by means of flash chromatography. 0.45 g of the desired target compound is obtained as a white solid of melting point 115-120°C.

Example H20: 3-(5.6-Dichloro-2-Dvridvl)- and 3-(4, 5-dichloro-2-pvridvl)-4-chloro-5- trifluoromethvl-1-methvl-Fl Hl-Dvrazole (isomer A and B) (Compound No. 14.485) and Isomer A isomer 20 ml of phosphorus oxychloride (POOl3) are heated up to 90"C. 10.37 g of 3-(5-chloro-2- pyridyl-N-oxide)-4-chloro-5-trifluoromethyl-1-methyl-[1H]-py razole (Example H18) are introduced in several portions at this temperature, while stirring, and the mixture is subsequently stirred at 90"C for 1 hour. The phosphorus oxychloride is then removed in vacuo and the residue is taken up in diethyl ether. The organic phase is then washed successively with water, 0.5 N sodium hydroxide solution and brine. After drying over sodium sulfate and filtering, the filtrate is concentrated. 8.93 g of a brown precipitate are obtained. This crude product is purified by column chromatography (silica gel; eluting agent: n-hexane/ethyl acetate 10/1). First, 0.57 g of isomer B is isolated, and then 5.11 g of isomer A are isolated as a white solid.

TLC analysis: silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 4/1 (v/v), UV: Rf value isomer A: 0.31 Rf value isomer B: 0.41 If 6.3 g of 3-(5-chloro-2-pyridyl-N-oxide)-4-chloro-5-trifluoromethyl-1- methyl-l1 H]-pyrazole (Example H18) are treated with 6.3 g of phosphorus pentachloride in 20 ml of phosphorus oxychloride at 90°C for 1 hour, 4.36 g of isomer A and 1.01 g of isomer B are obtained after the above working up.

Example H21: 3-(3-Fluoro-5,6-dichloro-2-pyridyl)- and 3-(3-fluoro-4.5-dichloro-2-Dyridvl)-4- chloro-5-difluoromethoxv-1 -methyl-Il H]-pyrazole (isomer A and B) (Compound No.11.003) and Isomer A isomer ii A mixture of 2.1 g of phosphorus pentachloride and 7 ml of phosphorus oxychloride is heated up to 90°C, 2.8 g 3-(3-fluoro-5-chloro-2-pyridyl-N-oxide)-4-chloro-5-difluorom ethoxy- 1 -methyl-[1 H]-pyrazole (Example H19) is then introduced in portions at this temperature and the mixture is stirred at the same temperature for 0.5 hour. Most of the phosphorus oxychloride is then removed in vacuo and the remaining mixture is stirred with warm water and ethyl acetate. The organic phase which has been separated off is washed with aqueous sodium bicarbonate solution and brine. After drying over sodium sulfate and filtering, the filtrate is concentrated in vacuo and the residue is purified by means of flash chromatography (silica gel; eluting agent: toluene/ethyl acetate 50/1). 0.69 g of isomer A is first isolated as a yellow oil, which later solidifies; melting point 63-67°C. 0.64 g of isomer B is then obtained as a white solid of melting point 121-123"C.

Example H22: 3-(6-Ethoxycarbonyl-5-chloro-2-pyridyl)-4-chloro-5-trifluoro methyl-1-methyl- (1 H1-Dyrazole (Compound No. 14.733) An autoclave is loaded with 7.0 g of 3-(5,6-dichloro-2-pyridyl)-4-chloro-5-trifluoromethyl-1- methyl-[1 H]-pyrazole (Example H20), 100 ml of dry ethanol, 9.0 ml of triethylamine and 0.83 g of palladium bistriphenylphosphine dichloride (PdCI2(PPh3)2). 140 bar of carbon monoxide are forced in at 25"C and the mixture is then kept at 12000 for 15 hours. After cooling to 25"C, the mixture is concentrated and the residue is then absorbed onto silica gel from ethyl acetate. This silica gel is introduced onto a flash chromatography column and the column is then eluted with a mixture of n-hexane/ethyl acetate 7/1 (v/v). 4.51 g of the desired title compound are obtained as a yellow solid (58% of theory).

TLC analysis: Rf value of the product (silica gel 60 F254, n-hexane/ethyl acetate 4/1 (v/v)): 0.19.

Example H23: 3-(6-Chlorocarbonyl-5-chloro-2-pyridyl)-4-chloro-5-trifluoro methyl-1-methyl- 11 Hj-ovrazole (Compound No. 14.546) 5.44 g of 3-(6-ethoxycarbonyl-5-chloro-2-pyridyl)-4-chloro-5-trifluoro methyl-1- -methyl-[l H]- pyrazole are initially introduced into a flask, and 4.1 ml of a 4 N solution of sodium hydroxide in 4.1 ml of a mixture of methanol/water 2/1 are added. The reaction mixture is heated up to 40°C and kept at this temperature overnight. It is then concentrated to dryness under a high vacuum and 2.2 ml of thionyl chloride are added to the resulting residue. The mixture is heated up to 80°C in the course of 2 hours. After cooling to 25"C, it is concentrated to dryness in vacuo. The residue is then diluted 3 times with carbon tetrachloride and in each case concentrated to dryness in vacuo. 5.56 g of a solid, which is used directly for the next reaction stage, are obtained.

Example H24: 3-F5-Chloro-6- (carboxylic acid 1 -allvloxvcarbonvl-l -methvl-ethvl ester)-2- pyridyl]-4-chloro-5-trifluoromethyl-1-methyl-[1H]-pyrazole (Compound No. 14.566) 2.56 g of allyl hydroxyisobutyrate are initially introduced into 15 ml of dry pyridine. 5.30 g of 3-(6-chlorocarbonyl-5-chloro-2-pyridyl)-4-chloro-5-trifluoro methyl-1-methyl-[1H]-pyrazole (Example H23) are added in several portions at 25°C, under an exothermic reaction, and the mixture is subsequently stirred overnight at 25°C. The reaction mixture is then concentrated in vacuo and the residue is taken up in ethyl acetate. The ethyl acetate phase is washed successively with water, dilute ammonium chloride solution, water, dilute sodium bicarbonate solution and water. 5.5 g of the desired title compound are obtained as a brown solid.

'H-NMR (CDCl3): 7.94 ppm (dl H); 7.84 ppm (d, 1 H); 5.94 ppm (m, 1 H); 5.29 ppm (m, 2H); 4.70 ppm (d, 2H); 4.07 ppm (s, 3H); 1.75 ppm (s, 6H) Example H25: 3-15-Chloro-6- (carboxvlic acid 1 -carboxv-I -methyl-ethyl ester)-2-pyridyl]-4- chloro-5-trifluoromethyl-1-methyl-[1H]-pyrazole (Compound No. 14.562) 3.53 9 of 3-[5-chloro-6-(carboxylic acid 1 -allyloxycarbonyl-l -methyl-ethyl ester)-2-pyridyl]-4- chloro-5-trifluoromethyl-1 -methyl-[1 Hj-pyrazole (Example H24) are initially introduced into 30 ml of acetonitrile together with 0.1 g of triphenylphosphine. After five evacuations under a water pump vacuum and subsequent gassing with argon, 0.22 g of Pd(PPh3)4 and, after cooling to 0°C, 0.70 ml of pyrrolidine are added under argon. The mixture is stirred at 25°C for 4 hours. It is then concentrated in vacuo and the resulting residue is partitioned between ethyl acetate and a phosphate buffer pH = 3. The organic phase is washed with the buffer solution and then with brine. After drying over sodium sulfate and filtering, it is concentrated to dryness in vacuo, 3.92 g of a brown solid remaining. After purification over a flash chromatography column (silica gel; eluting agent: n-hexane/ethyl acetate/acetic acid 100/100/3), 3.23 g of the desired title compound are obtained.

'H-NMR (DMSO-D6): 13.60 ppm (broad signal, 1H); 8.22 ppm (d, 1H); 8.03 ppm (d, 1H); 4.11 ppm (s, 3H); 1.62 ppm (s, 6H).

Example H26: 3-15-Chloro-6-(carboxvlic acid 1 -chlorocarbonvl-1 -methyl-ethvl ester)-2- ovridyll-4-chloro-5-trifluoromethyl-1 -methvl-F1 H1-pvrazole (Compound No. 14.804) 3.12 g of 3-[5-chloro-6-(carboxylic acid 1 -carboxy-l -methyl-ethyl ester)-2-pyridyll-4-chloro-5- trifluoromethyl-1 -methyl-[1 H]-pyrazole (Example H 25) are initially introduced into 20 ml of dry toluene and the mixture is heated up to 80°C After addition of one drop of N,N- dimethylformamide, 1.1 ml of thionyl chloride are added dropwise, while stirring. After the mixture has been subsequently stirred at 80°C for 1 hour, it is cooled to 25°C and concentrated in vacuo. After dissolving the resulting residue in 25 ml of absolute toluene and concentrating the solution again, 3.21 g of a yellow solid, which is used directly for the next reaction stage, are obtained.

Example H27: 3-[5-Chloro-6-(carboxylic acid 1-allylcarbamoyl-1-methyl-ethyl ester)-2- pyridyl]-4-chloro-5-trifluoromethyl-1-methyl-[1H]-pyrazole (Compound No. 14.570) 0.15 ml of allylamine is initially introduced into 4.0 ml of dry pyridine. 0.81 g of 3-[5-Chloro- 6-(carboxylic acid 1-chlorocarbonyl-1-methyl-ethyl ester)-2-pyridyl]-4-chloro-5- trifluoromethyl-1 -methyl-[1 H]-pyrazole (Example H26) is added in several portions, while stirring, at a temperature below 5°C and the mixture is then stirred at 25°C for 3 hours. The resulting dark red solution is partitioned between dilute hydrochloric acid and ethyl acetate.

After extraction by shaking and separation of the phases, the organic phase is washed successively with water, dilute sodium hydroxide solution and finally with brine. After drying over sodium sulfate, the mixture is filtered and the filtrate is concentrated to dryness. 0.79 g of the desired title compound is obtained as an orange solid.

'N-NMR (CDCl3): 7.99 ppm (d, 1H); 7.89 ppm (d, 1H); 7.07 ppm (broad signal, 1H); 5.81 ppm (m, 1H); 5.09 ppm (m, 2H); 4.08 ppm (s, 3H); 1.88 ppm (s, 6H).

Example H28: 3-(5-Chloro-6-methoxy-2-pyridyl)-4-chloro-5-trifluoromethyl- 1-methyl-[1H]- pyrazole (Compound No. 14.498) 1.0 g of 3-(5,6-dichloro-2-pyridyl)-4-chloro-5-trifluoromethyl-1 -methyl-[1 H]-pyrazole (Example H20) is initially introduced into 5 ml of dry dimethoxyethane. After the solution has been cooled to 0°C, 0.61 ml of a 5.4 molar solution of sodium methylate in methanol is added dropwise and the mixture is subsequently stirred at 25"C for 2 days. The reaction mixture is taken up in diethyl ether and washed successively with 0.5 N hydrochloric acid, water and brine. After drying over sodium sulfate, the mixture is filtered and the filtrate is concentrated to dryness in vacuo. 0.94 g of the desired title compound is obtained as a white solid.

'H-NMR (DMSO-D6): 7.99 ppm (d, IH); 7.50 ppm (d, lah); 4.08 ppm (s, 3H); 4.02 ppm (s, 3H).

Example H29: 3-[5-Chloro-6-(imidazol-1-yl)-2-pyridyl]-4-chloro-5-trifluor omethyl-1-methyl- 11 H1-ovrazole (Compound No. 14.729) 0.60 g of 3-(5,6-dichloro-2-pyridyl)-4-chloro-5-trifluoromethyl-1 -methyl-[1 H]-pyrazole (Example H20), 0.28 g of imidazole and 0.50 g of potassium carbonate are initially introduced into 10 ml of dry N-methylpyrrolidone. The mixture is stirred overnight at 10000 and then cooled to 25°C and partitioned between water and diethyl ether. After extraction by shaking and separation of the phases, the ether phase is washed with water, ammonium chloride solution and water. After drying over sodium sulfate and filtering, the filtrate is concentrated in vacuo and the residue is purified over a flash chromatography column (silica gel; eluting agent: n-hexane/ethyl acetate 1/2). 0.42 g of the desired compound is obtained as a white solid.

TLC analysis: silica gel 60 F254;eluting agent n-hexane/ethyl acetate 1/2; Rut value starting material: 0.71 Rf value target compound: 0.27.

Example H30: 3-(3-Fluoro-5-chloro-6-hydroxy-2-pyridyl)-4-chloro-5-difluor omethoxy-1- methyl-Fl Hi-pyrazole (Compound No. 11.005) 1.0 g of 3-(3-fluoro-5-chloro-2-pyridine-N-oxide)-4-chloro-5-difluoro methoxy-1 -methyl-[1 Hl- pyrazole is initially introduced into 12 ml of dry N,N-dimethylformamide. 4.2 ml of trifluoroacetic anhydride is added dropwise from a syringe, while stirring and cooling with an ice-bath, and the mixture is then subsequently stirred overnight at 25°C. It is then evaporated in vacuo and the residue is partitioned between diethyl ether and water. After extraction by shaking and separation of the phases, the ether phase is washed with dilute aqueous sodium bicarbonate solution and brine, dried over sodium sulfate, filtered and concentrated. 1.23 g of a yellow oil are obtained, and this is purified by means of flash chromatography (silica gel; eluting agent: n-hexane/ethyl acetate 2/3 (v/v) and 1 % glacial acetic acid). 0.59 g of the desired compound is obtained as a yellow solid of melting point 126-128°C.

Example H31: 3-(3-Fluoro-5-chloro-6-methoxy-2-pyridyl)-4-chloro-5-difluor omethoxy-1- methyl-Fl H1-pvrazole (Compound No. 11.022) 0.1 g of 3-(3-fluoro-5-chloro-6-hydroxy-2-pyridyl)-4-chloro-5-difluor omethoxy-1 -methyl-[l H]- pyrazole (Example H30) is initially introduced into 2.0 ml of dry N,N-dimethylformamide.

After addition of 0.12 g of dry powdered potassium carbonate, 0.06 g of methyl iodide in 1 ml of dry N,N-dimethylformamide is added at 25"C, while stirring. After 3 hours, the reaction mixture is partitioned between water and diethyl ether. The ether phase which has been separated off is washed with water and brine, dried over sodium sulfate, filtered and concentrated. After purification over a flash chromatography column (silica gel; eluting agent: n-hexane/ethyl acetate 2/1 (v/v)), 0.07 g of the desired product is isolated as a white solid.

TLC analysis: silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 1/1 (v/v): Rt value product: 0.57 Rf value precursor: 0.14.

Example H32: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-difluoromethyl-5-difluormo methoxy-1-methyl- Fl Hl-pvrazole (Compound No.1,03.002) 0.13 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-formyl-5-difluroomethoxy-1 -methyl-[1H]-pyrazole is initially introduced into 3.0 ml of dry 1,2-dichloroethane. 0.11 ml of diethylaminosulfur trifluoride (DAST) is added dropwise with a syringe, while stirring, the reaction mixture assuming a dark colour. The mixture is then stirred at 50°C for 1 hour. After cooling to 25"C, the reaction solution is applied directly to a flash chromatography column (silica gel) and eluted with n-hexane/ethyl acetate 5/1 (v/v). 0.07 g of the desired compound is obtained as a pale yellow solid of melting point 79-81"C.

Examnle H33: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-formyl-5-difluoromethoxy-1 -methyl-[1 H1- ovrazole (Compound No.1104.002) 2.41 ml of phosphorus oxychloride are introduced into 5 ml of N,N-dimethylformamide, while cooling in an ice-bath, and the mixture is subsequently stirred at 25°C for 2 hours. This mixture is then added dropwise to 5.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-hydroxy-1- methyl-[l H]-pyrazole (Example H14) in 15 ml of N,N-dimethylformamide at 80°C in the course of 30 minutes. After the mixture has been subsequently stirred at 80°C for 1.5 hours, it is cooled to 25"C, ice and then water are added and the mixture is extracted with diethyl ether. After washing the organic phase with water and drying over sodium sulfate, 1.1 g of a yellow solid is obtained as an intermediate. This is initially introduced into 10 ml of dry N,N-dimethylformamide together with 1.72 g of powdered anhydrous potassium carbonate.

The mixture is heated up to 75"C, while stirring thoroughly, and Freon 22 (CHCIF2) is passed in slowly for 7 hours. The mixture is then cooled to 25°C and taken up in diethyl ether. The ether phase is washed with water and then with brine, dried over sodium sulfate, filtered and concentrated. 1.50 g of crude product are obtained as a brown solid, which is purified by means of a flash chromatography column(silica gel; eluting agent: n-hexane/ethyl acetate 4/1 (v/v)). 0.14 g of the desired target compound is obtained as a yellow solid of melting point 11 1-1 1 6°C in this manner.

Example H34: 3-(3-Fluoro-5-chlroo-6-cyano-2-pyridyl)-4-chloro-5-difluorom ethoxy-1-methyl- 11 H1-ovrazole (Compound No. I1.009) 1.50 g of 3-(3-fluoro-5-chloro-2-pyridyl-N-oxide)-4-chloro-5-difluorom ethoxy-1- -methyl-[1 H]- pyrazole (Example H19) are initially introduced into 5 ml of dry acetonitrile, and 1.0 ml of triethylamine is then added. 1.43 ml of trimethylsilyl cyanide in 2 ml of acetonitrile are then added dropwise at 25°C in the course of 20 minutes, and the mixture is stirred for 2 days, while heating vigorously under reflux (bath temperature 110°C). After cooling to 25"C, the mixture is diluted with acetonitrile, adsorbed onto silica gel and introduced onto a flash chromatography column (silica gel). After eluting with a mixture of n-hexane/ethyl acetate 3/1 (vN), 0.74 g of the desired product is obtained as a yellow solid of melting point 133- 13400.

Example H35: 3-(3-Fluoro-5-chloro-6-vinyl-2-pyridyl)-4-chloro-5-difluorom ethoxy-1-methyl- 11 H1-pvrazole (Compound No. I1.740) 30 g of 3-(3-fluoro-5,6-dichloro-2-pyridyl)-4-chloro-5-difluorometho xy-1-methyl-[1 H]-pyrazole (Example H21) are dissolved in 200 ml of N,N-dimethylformamide (DMF). After addition of 32.9 9 of vinyltributyltin, the mixture is twice evacuated and gassed with argon. A little (i.e. a spatula-tip) 2,6-di-tert-butyl-p-cresol and 3.0 g of bistriphenylphosphinepalladium dichloride (PdC12(PPh3)2) are then added and the mixture is stirred at a temperature of 67°C for 24 hours. After cooling to 22"C, the reaction mixture is filtered over Hyflo and partitioned between dilute hydrochloric acid and diethyl ether. The ether phase which has been separated off is washed with water, dried over sodium sulfate, filtered and concentrated in vacuo. 84 g of a black oil are obtained, and this is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 6/1). The resulting solid is stirred with 100 ml of n-hexane for a further 2 hours, filtered off, washed and dried. 16.4 g of the desired title compound are obtained as a white solid of melting point 75-77"C.

Example H36: 3-(3-Fluoro-5-chloro-6-formyl-2-pyridyl)-4-chloro-5-difluoro methoxy-1-methyl- 11 H1-Dvrazole (Compound No.1, .113) 13.2 g of 3-(3-fluoro-5-chloro-6-vinyl-2-pyridyl)-4-chloro-5-difluorom ethoxy-1 -methyl-[1 H]- pyrazole (Example H35) are initially introduced into a mixture of 120 ml of dioxane and 40 ml of water. 16.7 g of sodium (meta)periodate (NalO4) and a spatula-tip of osmium tetroxide are added, while stirring, and the mixture is subsequently stirred overnight at 22°C.

The following day, the resulting mixture is taken up in ethyl acetate and washed first with dilute hydrochloric acid and then with brine. After drying over sodium sulfate, the mixture is filtered and the filtrate is concentrated in vacuo. After purification over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 2/1), 9.4 g of the desired title compound are obtained as a white solid of melting point 120-121 °C.

Example H37: 3-T3-Fluoro-5-chloro-6-(carboxvlic acid I -carboxv-1 -methyl-ethyl ester)-2- pyridyl]-4-chloro-5-difluoromethoxy-1-methyl-[1H]-pyrazole (Compound No. 11.152) 4.9 g of 3-E3-Fluoro-5-chloro-6- (carboxylic acid 1 -benzyloxycarbonyl- 1-methyl-ethyl ester)-2- pyridyl]-4-chloro-5-difluoromethoxy-1- -methyl-[1 H]-pyrazole are hydrogenated with 1.0 g of 5% palladium on active charcoal in 70 ml of ethyl acetate at 22°C under normal pressure.

After 20 minutes, the mixture is filtered over Hyflo, dried over sodium sulfate, filtered and concentrated in vacuo. The resulting crude product is purified over a silica gel flash column (eluting agent: toluene/acetic acid 10/1). 3.8 g of the desired title compound are obtained as a white solid of melting point 133-134°C.

Example H38: 3-[3-Fluoro-5-chloro-6-(carboxylic acid 1 -isoDropvlmercaDtocarbonvl- 1- methyl-ethyl ester)-2-pyridyl]-4-chloro-5-difluoromethoxy-1-methyl-[1H]-p yrazole (Compound No. I1.164) 2.23 g of 3-[3-fluoro-5-chloro-6-(carboxylic acid 1 -carboxy-1 -methyl-ethyl ester)-2-pyridyl]-4- chloro-5-difluoromethoxy-1-methyl-[1 H]-pyrazole (Example H37) are initially introduced into 10 ml of methylene chloride. A catalytic amount of DMF and 0.67 g of oxalyl chloride, in portions, are added to the white suspension (evolution of gas). The mixture is subsequently stirred at 22"C for 1 hour. The colourless acid chloride solution thus obtained can be further used directly.

0.64 9 of triethylamine and 1 spatula-tip of p-dimethylaminopyridine (DMAP) are initially introduced into 10 ml of ethyl acetate. 0.23 9 of 2-propanethiol is added, while cooling with ice, and half of the acid chloride solution obtained above is added dropwise in the course of 15 minutes. The mixture is then stirred at 22"C for 3 hours. Thereafter, the remaining amount of 2-propanethiol is removed with argon gas passed over Javelle water. The resulting mixture is diluted with ethyl acetate and washed with dilute hydrochloric acid and then with brine. The resulting crude product is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 4/1). 1.16 g of a colourless oil which slowly crystallizes out are obtained. The solid is comminuted and stirred with 3 ml of n-hexane. After filtration with suction, washing and drying, 1.05 g of the desired title compound are obtained as white crystals of melting point 81-82"C.

Example H39: 3- (3-Fluoro-5-chloro-6-methacrvlic acid ethyl ester-2-pyridyl)-4-chloro-5- difluoromethoxv-l -methyl-lI H1-pyrazole F Cl ci 2 CH CH3 C~CH3 o=c (i"'z-Gemisch) OC,H, (Compound No.11.764) 1.00 g of 3-(3-fluoro-5-chloro-6-formyl-2-pyridyl)-4-chloro-5-difluoro methoxy-I -methyl-[l H]- pyrazole (Example H36) is initially introduced into 6 ml of dioxane and 0.1 ml of water, and 0.88 g of triethyl 2-phosphonopropionate and 1.44 g of caesium carbonate are added. The mixture is then stirred at 80"C for 2 hours and the resulting reaction mixture is diluted with ethyl acetate and washed first with dilute hydrochloric acid and then with brine. After drying over sodium sulfate, filtering and concentrating in vacuo, the residue is purified over a silica gel flash column (eluting agent: toluene/ethyl acetate 10/1). 0.86 g of an isomer A and 0.37 g of an isomer B are obtained.

rH-NMR (CDC13): Isomer A: 7.56 ppm (d, 1 H); 6.86 ppm (m, I H); 6.70 ppm (t, 1 H); 4.05 ppm (q, 2 H); 3.85 ppm (s, 3 H); 2.15 ppm (m, 3 H); 1.03 ppm (t, 3 H).

Isomer B: 7.85 ppm (m, 1 H); 7.62 ppm (d, 1 H); 6.72 ppm (t, I H); 4.29 ppm (q, 2 H); 3.87 ppm (s, 3 H); 2.29 ppm (m, 3 H); 1.35 ppm (t, 3 H).

Example H40: 3-(3-Fluoro-5-chloro-2-pyridyl)-5-bromo-1-methyl-[1 H]-pvrazole (Compound No. I131.035) 20.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-hydroxy-1-methyl-[1H]-pyra zole (Example H14) are initially introduced into 80 ml of tetrachloroethane. A total of 25.2 g of phosphorus oxybromide (POBr3) are added in portions to the brown suspension and the mixture is then stirred at a temperature of 13000 for 2 hours. Thereafter, it is cooled and 150 ml of a 2 molar sodium hydroxide solution are added dropwise, while cooling with an ice-bath. After addition of diethyl ether and separation of the phases, the organic phase is washed successively with water, dilute hydrochloric acid and brine, dried over sodium sulfate, filtered and concentrated in vacuo. 19.94 g of a brown solid are obtained as the crude product, and this solid is purified by means of digestion with 50 ml of n-hexane. 12.65 g of the desired title compound are obtained as a brown solid of melting point 110-111°C.

Example H41: 3-(3-Fluoro-5-chloro-2-pyridyl)-5-ethoxycarbonyl-1-methyl-[1 H]-pyrazole 5.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-bromo-1-methyl-[1 H]-pyrazole (Example H40) are initially introduced into an autoclave together with 7.2 ml of triethylamine, 0.48 g of bis- triphenylphosphinepalladium dichloride (PdCI2(PPh3)2) and 70 ml of absolute ethanol.

100 bar of carbon monoxide are forced in at 22°C and the mixture is then kept at 10000 for 48 hours. In the meantime, a further 0.48 g of bis-triphenylphosphinepalladium dichloride is added. The mixture is then cooled to 22"C and the pressure is released. The resulting reaction mixture is filtered over Hyflo and - after removal of the ethanol - taken up in ethyl acetate. The ethyl acetate phase is washed with dilute hydrochloric acid and then with brine, dried over sodium sulfate, filtered and concentrated in vacuo. 3.17 g of a brown solid are obtained, and this gives, after purification over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 2/1), 2.31 g of the desired title compound as a pale yellow solid of melting point 117-118°C.

Example H42: 3-(3-Fluoro-5-chloro-2-ovridvl)-4-chloro-5-trifluoromethvl-1 -methyl-t1 H1- pvrazole (Compound No. 14.002) 8.63 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-chloro-5-carboxy-1 -methyl-[1 H]-pyrazole are initially introduced into a fluorinating unit with 27 g of hydrogen fluoride (HF), 16.2 g of sulfur tetrafluoride (SF4) and 270 ml of methylene chloride. This mixture is kept at 80"C for 5 hours. It is then cooled to 22"C and the SF4 is removed via a gas elimination unit (stream of argon) and the HF is removed under a water pump vacuum. After addition of methylene chloride, the mixture is extracted three times with ice-water and the organic phase which has been separated off is dried over sodium sulfate and then concentrated in vacuo together with 40 g of silica gel. After application of this silica gel to a flash column, the column is eluted with a mixture of n-hexane/ethyl acetate 5/1. 5.48 g of the desired title compound are obtained as a beige solid of melting point 76-78°C.

Example H43: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-methyl-5-carboxy-1 -methyl-Il H1-vrazole (Compound No. liSo.035) 6.75 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-methyl-5-methoxycarbonyl-1 -methyl-[1 H]-pyrazole are suspended in 40 ml of dimethyl sulfoxide. 14.3 ml of a 2 molar sodium hydroxide solution are added dropwise, while cooling occasionally in an ice-bath (temperature < 30°C). The thick yellow-brown suspension is stirred at 22°C for 2 hours. The resulting suspension is then introduced into ice-water and the pH is brought to 1 with 2 molar hydrochloric acid. The slurry formed is filtered with suction and the solid is washed thoroughly with cold water and then dried in vacuo at 60°C. 5.97 g of the desired title compound are obtained as a beige solid of melting point 194-196°C.

Example H44: 3- (3-Fluoro-5-chloro-2-pyridyl)-4-methyl-5-carbamovl-1 -methvl-l1 H1-nyrazole (Compound No. 1110.035) 3.0 9 of 3-(3-fluoro-5-chloro-2-pyridyl)-4-methyl-5-carboxyl-1 -methyl-[1 H]-pyrazole (Example H43) are initially introduced into 25 ml of 1,2-dichloroethane, a total of 1.2 ml of thionyl chloride are slowly added at 80°C and the mixture is subsequently stirred at 80°C for 5 hours. The resulting mixture is concentrated in vacuo and three times 20 ml of carbon tetrachloride are added and in each case the mixture is evaporated to dryness.

The resulting acid chloride is initially introduced into 35 ml of tetrahydrofuran, and ammonia gas is passed in, while cooling in an ice-bath. A brown precipitate forms. Stirring is continued overnight at 22°C. The resulting suspension is then introduced into five times the volume of ice-water. After brief subsequent stirring, the solid is filtered off with suction, washed with cold water and dried in vacuo at 60°C. 2.0 g of the desired title compound are obtained as a brown solid of melting point 201-204°C in this manner.

Example H45: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-methyl-5-cyano-1 -methyl-[1 H]-pyrazole (Compound No. leo.002) 1.82 g of 3-(34luoro-5-chloro-2-pyridyl)-4-methyl-5-carbamoyl-l -methyl-[l H]-pyrazole (Example H44) are suspended in 20 ml of dioxane. First 1.65 ml of pyridine and then 1.44 ml of trifluoroacetic anhydride are added, while cooling in an ice-bath. 5 minutes later, the cooling bath is removed and the mixture is stirred at 22°C for 1 hour. The brown-red solution is diluted with diethyl ether and washed with one molar hydrochloric acid and then with brine. After drying over sodium sulfate and filtering, the filtrate is concentrated directly together with twice the amount of silica gel. After application of this silica gel to a flash column, the column is eluted with n-hexane/ethyl acetate 4/1. 1.60 g of the desired title compound are obtained as a beige solid of melting point 144-146°C.

Example H46: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-iodo-5-difluoromethoxy-1-m ethyl-[1H]- Dvrazole (Compound No.1,3s.o35) 3.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-difluoromethoxy-1 -methyl-[l H]-pyrazole (Example H15) are dissolved in 30 ml of methylene chloride, and 1.83 g of silver(l) nitrite and 3.02 g of iodine are then added. The mixture is stirred overnight at 22°C. It is then diluted with diethyl ether and extracted successively with aqueous sodium metabisulfite solution and brine. After drying of the organic phase over sodium sulfate and filtration, the filtrate is concentrated in vacuo together with twice the amount of silica gel. After application of this silica gel to a flash column, the column is eluted with n-hexane/ethyl acetate (3/1). 3.97 g of the desired title compound are obtained as a beige solid of melting point 77-78°C in this manner.

Example H47: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-nitro-5-difluoromethoxy-1 -methyl11 H1- pyrazole (Compound No.1136.035) 4.0 g of 3-(34luoro-5-chloro-2-pyridyl)-5-difluoromethoxy-1 -methyl-[l H]-pyrazole (Example H15) are initially introduced into 30 ml of methylene chloride. 3.83 g of nitronium tetrafluoroborate are added, while stirring and cooling in an ice-bath, and the mixture is subsequently stirred overnight at 2200 The following day, it is poured onto water, and ethyl acetate is added. After extraction by shaking and separation of the phases, the organic phase is washed with dilute bicarbonate solution and brine, dried over sodium sulfate, filtered and concentrated in vacuo. 4.35 g of the desired title compound are obtained as a brown solid of melting point 108-109°C.

Example H48: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-amino-5-difluoromethoxy- 1-methyl-Fl Hi- pvrazole (Compound No.1,34.035) 4.2 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-nitro-5-difluoromethoxy-1- methyl-[1H]-pyrazole (Example H47) are initially introduced into the reaction vessel together with 40 ml of tetrahydrofuran, and 5.8 g of Raney nickel in ethanol are added. Hydrogenation is carried out under normal pressure and at a temperature of 30-35°C. After uptake of 728 ml of hydrogen, the hydrogenation is interrupted and the reaction mixture is filtered over Hyflo.

After removal of the solvent in vacuo, 3.15 g of the desired title compound are obtained as a brown solid of melting point 92-94"C.

Example H49: 3-(3-Fluoro-5-chloro-2-pyridyl)-4-(2-chloropyroplonamido)-5- difluoromethoxy- I-methyl-Fl H1-pyræole (Compound No. 1147.101) 1.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-4-amino-5-difluoromethoxy-1 -methyl-[l H]-pyrazole (Example H48) is initially introduced into 4 ml of pyridine. 0.46 g of racemic 2-chloropropionyl chloride in 4 ml of methylene chloride is added dropwise over 30 minutes, while stirring and cooling in an ice-bath, and the mixture is then subsequently stirred at 22°C for 2 hours. The reaction mixture is taken up in ethyl acetate and washed with dilute hydrochloric acid and then with brine. After drying over sodium sulfate and filtering, the filtrate is concentrated in vacuo and the residue is then purified over a silica gel flash column (eluting agent: toluene/ethyl acetate 10/1). 0.98 g of the desired title compound is obtained as a white solid of melting point 153-154"C.

Example H50: 3-(3-Fluoro-5-chloro-6-amino-2-pyridyl)-4-chloro-5-difluorom ethoxy-1-methyl- (1 H1-pyrazole (Compound No. I1.004) 1.84 g of 3-(3-fluoro-5-chloro-6-aminocarbonyl-oxymethyl-2-pyridyl)-4- chloro-5- difiuoromethoxy-l -methyl-[l H]-pyrazole are initially introduced into 35 ml of N-methylpyrrolidone together with 0.66 g of potassium carbonate. A preheated oil bath of 15000 is then applied and the mixture is heated overnight at this temperature. The following day, the reaction mixture is cooled to 22"C, poured onto ice-water and then extracted with diethyl ether. The ether phase is washed with brine and dried over sodium sulfate, filtered and concentrated in vacuo together with twice the amount of silica gel. After application of this silica gel to a flash column, the column is eluted with a mixture of n-hexane/ethyl acetate 1/1. 0.67 g of the desired title compound is obtained as a yellow solid.

TLC analysis: silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 1/1: Rf value of the product: 0.33.

Example H51: 3-(3-Fluoro-5-chloro-6-isoDronVlFio-2-ovridvl!-4-chloro-5-di fluoromethoXv-1- methvl- Fl H1-ovrazole (Compound No. 11.088) 0.79 g 3- (3-fluoro-5-chloro-2-pyridyl-N-oxide)-4-chloro-5-difluoromet hoxy- 1 -methyl-[I H]- pyrazole (Example H19) is initially introduced into 15 ml of benzene. Half of the benzene is distilled off. The mixture is cooled to 5°C in an ice-bath, while stirring, 0.22 ml of dimethylcarbamoyl chloride is added dropwise and the mixture is subsequently stirred at a temperature below 5"C for 30 minutes. Cooling in the ice-bath is continued, and 0.67 ml of triethylamine and 0.34 ml of 2-propanethiol are added. The mixture is then stirred overnight, while heating under reflux. After cooling in an ice-bath, 0.15 ml of dimethylcarbamoyl chloride and, 10 minutes later, 0.50 ml of triethylamine and 0.23 ml of 2-propanethiol are added. The mixture is then again boiled at the reflux temperature overnight. After diluting with diethyl ether, the mixture is washed successively with dilute hydrochloric acid, water, dilute sodium bicarbonate solution and brine. After drying over sodium sulfate and filtering, the filtrate is concentrated in vacuo and the residue is purified over a silica gel flash column (eluting agent: toluene/ethyl acetate 30/1). 0.22 g of the desired title compound is obtained as a colourless oil, which then crystallizes out (melting point 63-64"C).

Example H52: 3-Fluorod-chloro9- [(2-tert-butoxycarbonyl)-propanoyl]-pyridine (Compound No. llls.035) 32.3 g of diisopropylamine are initially introduced into 200 ml of tetrahydrofuran, and 200 ml of a 1.6 molar solution of n-butyllithium in hexane are added dropwise, while cooling with a carbon dioxide (CO2)/acetone cooling bath. Thereafter, 49.2 ml of tert-butyl propionate are added dropwise at about -75°C and the mixture is subsequently stirred at this temperature for 45 minutes. Finally, a solution of 32.6 g of ethyl 3-fluoro-5-chloro-2-pyridinecarboxylate (Example H1) in 40 ml of tetrahydrofuran (THF) is then added dropwise at about -75°C and the mixture is subsequently stirred at this temperature for 1 hour. Thereafter, the mixture is diluted with 250 ml of tert-butyl methyl ether, and a mixture of 100 ml of water and 200 ml of acetic acid is added. After separation of the phases, the aqueous phase is extracted again with tert-butyl methyl ether and the combined organic phases are then washed with water.

After drying over magnesium sulfate, the mixture is filtered and the filtrate is concentrated to dryness in vacuo. 51 g of an oil are obtained as the crude product.

TLC analysis: silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 3/1 (UV): Rf value of the starting material: 0.46; Rf value of the product: 0.63.

Example H53: 3-Fluoro-5-chloro-2-(2-carboxypropanoyl)-pyridine (Compound No. 1119.035) 25.5 g of the crude product 3-fluoro-5-chloro-2-[(2-tert-butoxycarbonyl)-propanoyl]-pyri dine (Example H52) are added dropwise to 30 ml of a 33% solution of hydrogen bromide (HBr) in glacial acetic acid, a suspension being formed. This suspension is subsequently stirred for 90 minutes. The mixture is then introduced into 300 ml of ice-water and the precipitate formed is filtered off with suction, washed with water and dried. 15.9 g of the desired title compound are obtained as a solid of melting point 101-102"C.

Example H54: 3-Fluoro-5-chloro-2-(2-chloroDroDanovl)-pyridine 20.8 9 of 3-fluoro-5-chloro-2-(2-carboxypropanoyl)-pyridine (Example H53) are initially introduced into 125 ml of glacial acetic acid. 6.3 g of chlorine gas are passed into the solution in the course of 1 hour and the mixture is then poured onto 700 ml of water and extracted with tert-butyl methyl ether. The ether phase is washed with water and dried over magnesium sulfate, filtered and evaporated in vacuo.

The resulting crude product is dissolved in 180 ml of tert-butyl methyl ether, and 45 g of silica gel are added. The mixture is stirred for 30 minutes, and initially observed evolution of gas ceasing. The silica gel is then filtered off and rinsed and the combined ether phases are concentrated in vacuo. The resulting crude product (20.1 g of an oil) is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 4/1). 17.0 g of the desired title compound are obtained as a solid of melting point 29-32"C.

Example H55: 5-(5-Chloro-3-fluoro-2-pyridyl)-3,6-dimethyl-3,6-dihydro-[1, 3,4]-thiadiazine- thione 19.1 ml of a 4 molar sodium hydroxide solution and 3.5 9 of methylhydrazine are initially introduced into 76 ml of ethanol. 4.5 ml of carbon disulfide are added dropwise whilst stirring at a temperature below 5°C and the mixture is subsequently stirred for 30 minutes.

17.0 g of 3-fluoro-5-chloro-2-(2-chloropropanoyl)-pyridine (Example H54) are then added in the course of 15 minutes at a temperature below 5"C. Thereafter, the temperature is allowed to rise to 22"C and the reaction mixture is subsequently stirred for 30 minutes. TLC analysis (silica gel 60 F254; eluting agent: n-hexane/ethyl acetate 5/1 (UV)) of a worked-up sample shows that at this point in time no further starting material is present. 2.5 ml of a concentrated hydrochloric acid solution are then added dropwise, a yellow precipitate being formed. The mixture is stirred for 1 hour and then poured onto water and extracted with tert- butyl methyl ether. The ether phase is washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo. 20.3 g of the desired title compound are obtained as a solid of melting point 107-112°C in this manner.

Example H56: 3-(3-fluorn-5-chlorn-2-Dyndvl)-4-methyl-5-methvlmernapto- 1 -methyl-Fl Hi- pvrazole (Compound No.1,8.002) 21.6 g of 5-(5-chloro-3-fluoro-2-pyridyl)-3,6-dimethyl-3,6-dihydro-[1, 3,4]-thiadiazine-thione (Example H55) are initially introduced into 70 ml of tert-butanol. 19.1 g of triphenylphosphine are then added and the mixture is stirred at a temperature of 65"C for about 15 minutes, a clear solution being formed. After cooling to 22"C, a suspension is again formed, to which 8.2 g of potassium tert-butylate are added in portions at a temperature below 40°C (cooling in an ice-bath). The mixture is then subsequently stirred overnight and thereafter poured onto 600 ml of water, stirred, filtered with suction and washed, and the aqueous phase is extracted thoroughly with tert-butyl methyl ether. The aqueous phase is rendered strongly acid with concentrated hydrochloric acid and extracted with tert-butyl methyl ether. The ether phase is washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo. 6.8 9 of a crude intermediate are obtained in this manner.

1.9 g of this crude product are dissolved in 10 ml of DMF, and 2.2 g of potassium carbonate are added. Thereafter, 0.5 ml of methyl iodide in 2 ml of DMF is added dropwise under a slightly exothermic reaction. The mixture is then subsequently stirred at 22°C for 5 hours and thereafter poured onto 120 ml of ice-water and extracted with diethyl ether. The ether phase is washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue (1.8 g of an oil) is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 2/1. 1.3 g of the desired title compound are obtained as a solid of melting point of 61-64"C.

Example H57: 3-(3-Fluoro-5-chloro-2-pvridvl)-4-methyl-5-methvlsuilfoxY-1 1-methyl- (1 Hi- pvratole and 3- (3-fluoro-5-chloro-2-Dyridyl)-4-methvl-5-methylsulfonvl- 1-methyl-Il Hi- Dvrazole (Comp. No. I19.002) (Comp. No. I20.002) 2.1 9 of 3-(3-fluoro-5-chloro-2-pyridyl)-4-methyl-5-methylmercapto-1 -methyl-[1 H]-pyrazole (Example H56) are dissolved in 40 ml of methylene chloride, and a total of 2.84 g of 70% meta-chloroperbenzoic acid are added in portions. The mixture is then stirred at 22°C for 4 hours. It is subsequently stirred with one molar sodium bicarbonate solution for 30 minutes. The organic phase which has been separated off is washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo. 1.7 g of a solid are obtained, and this is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 1/1).

0.80 g of the desired sulfone of melting point 145-147°C and 0.70 g of the desired sulfoxide of melting point 112-1140C are obtained in this manner.

Example H58: 3-(3-Fluoro-5-chloro-6-(1-hydroxy-2-propyn-3-yl)-2-pyridyl)- 4-chloro-5- difluoromethoxv-1 -methvl-ll Hi-yrazole (Comp. No. I1.190) 2.0 g of 3-(3-fluoro-5,6-dichloro-2-pyridyl)-4-chloro-5-difluorometho xy-1 -methyl-[1 H]- pyrazole (Example H21) are initially introduced into 15 ml of triethylamine, and 0.37 ml of propargyl alcohol is added. The mixture is then evacuated and gassed with argon 3 times under a partial water pump vacuum. Thereafter, 0.03 g of copper(l) iodide and 0.12 g of bis- triphenylphosphine-palladium dichloride (PdC12(PPH3)2) are added and the mixture is stirred overnight at 67°C under argon. The following day, after cooling to 22"C, 0.20 ml of propargyl alcohol, 0.03 g of copper(l) iodide and 0.12 g of PdC12(PPH3)2 are added. The mixture is then stirred at 67°C for 6 hours. After cooling to 22"C, ethyl acetate is added and the mixutre is washed successively with dilute hydrochloric acid, water and brine. After drying over sodium sulfate, filtration and concentration in vacuo, the residue is purified over a silica gel flash column (eluting agent: n-hexane/ethyl acetate 1/1). 0.97 g of the desired title compound is obtained as a yellow oil which gradually crystallizes; melting point 92- 94°C.

Example H59: 3-(3-Fluoro-5-chloro-6-(N-Pronaravl-N-ethylsulfonvl!-amino-2 -nvridyl)-4- chloro-5-difluorometho:':v-1 -methyl-Fl H1-Dvrazole (Comp. No. 11.747) 0.81 g of 3-(3-fluoro-5-chloro-6-amino-2-pyridyl)-4-chloro-5-difluorom ethoxy-1 -methyl-[l H]- pyrazole (Example H50) is dissolved in 10 ml of methylene chloride. 0.93 ml of triethylamine and then 0.54 ml of ethanesulfonyl chloride (CH3CH2SO2CI) are added, while stirring and cooling in an ice-bath, and the mixture is subsequently stirred at 22"C for 48 hours. Diethyl ether is added to the reaction mixture and the mixture is washed with dilute hydrochloric acid and then with brine. After drying over sodium sulfate, filtering and concentrating in vacuo, 1.0 g of an intermediate product is obtained, and this is dissolved in 10 ml of dioxane. 2.0 ml of a 2 molar aqueous sodium hydroxide solution are added dropwise, while cooling in an ice-bath and stirring, and the mixture is subsequently stirred at 22°C for 1.5 hours. It is then diluted with diethyl ether and rendered acid with hydrochloric acid. After extraction by shaking and separation of the phases, the ether phase is washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The intermediate obtained in this manner is dissolved in 20 ml of N-methylpyrrolidone (NMP) and the solution is stirred and cooled in an ice-bath. 2.0 g of potassium carbonate are then added, and 0.45 ml of propargyl bromide is added dropwise. The mixture is subsequently stirred, with the ice-bath thawing, and is then partitioned between ice-water and diethyl ether. After extraction by shaking and separation of the phases, the ether phase is washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo together with twice the amount of silica gel. After application of the silica gel to a flash column, the column is eluted with n- hexane/ethyl acetate 2/1). 0.34 g of the desired title compound is obtained as a brown- yellow solid of melting point 138-139"C.

Example H60: 3-(3-Fluoro-5-chloro-6-carbamoylmethylenoxy-2-pyridyl)-4-chl oro-5- difluoromethoxy-1-methyl-[1H]-pyrazole (Comp. No. I1.061) 3.0 g of 3-(3-fluoro-5-chloro-6-hydroxy-2-pyridyl)-4-chloro-5-difluor omethoxy-1- -methyl-[1 H]- pyrazole (Example H30) are initially introduced into 30 ml of N-methylpyrrolidone (NMP) together with 2.53 g of potassium carbonate, and 0.96 g of chloroacetamide is then added.

The mixture is stirred overnight at 50°C. After cooling to 22°C, it is then poured onto ice- water and a little diethyl ether is added. The slurry formed is filtered with suction and the solid is washed successively with water, diethyl ether and n-hexane. After drying in vacuo at 50°C, 2.35 g of the desired title compound are isolated as a beige solid.

H-NMR (CDCl3): 7.64 ppm (d, 1 H); 6.72 ppm (t, 1 H); 6.50 ppm (broad, 1 H); 5.60 ppm (broad, 1 H); 4.6 ppm (s, 2 H); 3.87 ppm (s, 3 H).

Example H61: 3-(3-Fluoro-5-chloro-2-Dvridyl)-5-(2.22-trifluoroethoXv)-1 -methyl-[1H]- pyrazole (Comp. No, I132.035) 3.0 g of 3-(3-fluoro-5-chloro-2-pyridyl)-5-hydroxy-1-methyl-[1H]-pyra zole (Example H14) are initially introduced into 30 ml of N-methylpyrrolidone (NMP) together with 3.64 g of potassium carbonate, and 3.49 g of 2,2,2-trifluoro-ethanol 4-methylbenzenesulfonate are added. 0.3 g of sodium iodide is then added and the mixture is stirred ovemlght at 80°C. It is then cooled to 22°C and partitioned between dilute hydrochloric acid and diethyl ether.

After extraction by shaking and separation of the phases, the ether phase is washed with brine, filtered and concentrated in vacuo together with twice the amount of silica gel. After application of the silica gel to a flash column, the column is eluted with n-hexane/ethyl acetate 2/1. 2.68 g of the desired title compound are obtained as a yellow solid of melting point 72-73°C.

The compounds listed in the following tables can also be prepared in an analogous manner.

In the following tables 1 to 4, certain structures In, 111-1113, 1111-1119, IV1, IV2, V1 or V2, for example I1 to 134 in Table 1 or I107 to 1136; I149-I156; II1-II13; 1ll1-lll9; 1V1, lV2; V1 and V2 in Table 4, with the same substituent variations, for example R11 and R13 in Table 1 or R11, R12 and R13 in Table 4, are combined for simplification.

In the tables mentioned, all the structures In or 111-1112,1111-1119, 1V1, IV2, V1 or V2, where for Table 1 n=1 to 34, mentioned in the heading of the tables should thus be combined with the definitions given in the tables. For example, in Table 1, In.001 discloses each of the 34 specific compounds I1.001, I2.001, I3.001, I4.001, I5.001, I6.001, I7.001, I8.001 and so on up to 134.001, in which in each case R11 and R13 are fluorine.

Table 1: Compounds of the formulae I1 to 134 Comp.No. R11 R13 In n = 1-34 001 F F 002 F H 003 F Cl 004 F NH2 005 F OH 006 F SH 007 F Br 008 F 009 F CN 010 F SO2Cl 011 F NH(CH3) 012 F N(CH2CH3)2 013 F NH(COCH3) 014 F NH(CH2CH=CH2) Comp.No. R11 R13 In n = 1-34 015 F N(CH3)(CH2C-CH) 016 F N (SO2CH3)2 017 F NH(SO2CH2CH3) 018 F N(CH2CH=CH2)(SO2CH2CH3) 019 F N(CH2C=CH)(SO2CH(CH3)2) 020 F N(CH2CF3)(CHO) 021 F NH(CH2C H5) 022 F OCH3 023 F OCH2CH3 024 F OCH(CH3)2 025 F OCH(CH3)CH2CH2CH3 026 F OCH2CH=CH2 027 F OCH(CH3)CH=CH2 028 F OCH2C=CH 029 F OCH(CH3)C=CH 030 F OCH (cyclopentyl)2 031 F OCH2(CôHs) 032 F OCH2(2-F-C6H5) 033 F OCH(CH3)(4-CH3-C6H5) 034 F OC6H5 035 F 0(4-pyrimidyl) 036 F OCH2CH2CI 037 F OCH2CH=CHCI 038 F OCH2CH2OH 039 F OCH2OCH3 040 F OCH2CH2OCH2CH3 041 F OCH2CH2OCH2CH2OCH2CH3 042 F OCH(CH3)CH2OCH2CH=CH2 043 F OCOCH3 044 F OCOOCH3 Comp.No. R11 R13 In n=1-34 045 F OCOCH2C6H5 046 F OCH2SCH3 047 F OCH2CH2SCH2CH3 048 F OCH2COOH 049 F OCH(CH3)COOH 050 F (R)-OCH(CH3)COOH 051 F (S)-OCH(CH3)COOH 052 F OCH2COOCH2CH3 053 F OCH(CH3)COOCH3 054 F OCH(CH3)COOCH2CH=CH2 055 F OCH(CH3)COOCH2(C6H5) 056 F OCH(CH3)CH2COOH 057 F OCH(CH3)CH2COOCH2CH3 058 F OCH2COSCH3 059 F OCH(CH3)COSCH2CH3 060 F OCH(CH3)COSCH(CH3)2 061 F OCH2CONH2 062 F OCH2CON(CH2CH3)2 063 F OCH(CH3)CON(CH3)2 064 F OCH(CH3)CONH(CH2CH=CH2) 065 F OCH(CH3)CON(CH3)(CH2C CH) 066 F OCH(CH3)CON(CH2C6H5)2 067 F OCH(CH3)CON(CH3)(C6H5) 068 F OCH2COOCH2CH2SCH3 069 F OCH(CH(CH3)2)COOH 070 F OCH(CH3)COOCH2CH2OCH2CH3 071 F OCH(C6H5)COOH 072 F (R)-OCH(C6H5)COOH 073 F (S)-OCH(C6H5)COOH 074 F OCH(C6Hs)COOCH3 Comp.No. R11 R13 In n=1-34 075 F OCH(C6H5)COOCH(CH3)C#CH 076 F OCH(C6H5)COOCH2C6H5 077 F OCH(C6H5)COSCH(CH3)2 078 F OCH(C6H5)CONH2 079 F OCH(C6H5)CONH(CH2CiCH) 080 F OCH(C6Hs)CON(CH2CH=CH2)2 081 F OCH(C6H5)CON(CH3)CH2C6H5 082 F OCH(C6H5)CONH(CH2)2-F-C6H5)) 083 F OCH(C6H5)CONH(cyclopropyl) 084 F OCH2CH2COOH 085 F OCH2CH2COOCH2CH3 086 F OCH(CH3)CH2COOH 087 F SCH3 088 F SCH(CH3)2 089 F SCH2CH=CH2 090 F SCH2C6H5 091 F SCH2CH20CH3 092 F SC6H5 093 F SCH2COOH 094 F SCH2COOCH2C6Hs 095 F SCH(CH3)COOH 096 F SCH(CH3)COOCH2CH3 097 F SCH(CH3)COOCH2CH=CH2 098 F SCH(CH3)COSCH3 099 F SCH(CH3)CON(CH3)2 100 F SCH(CH3)CONH(CH2CH=CH2) 101 F SOCH2CH3 102 F SO2CH3 103 F S02NH2 104 F S02N(CH3)2 Comp.No. R11 R13 In n=1-34 105 F SO2N(CH2CH3)2 106 F SO2N (CH3) (CH2(4-CH3-C6Hs)) 107 F SO2NHCH2CH20CH3 108 F SCOOCH3 109 F SCON(CH3)2 110 F SCONHCH2CH=CH2 111 F SCOOCH2CHCH2 112 F SCON(CH2CH3)COCF3 113 F CHO 114 F COCH3 115 F COOCH2CH3 116 F CO0CH2C6H5 117 F COCI 118 F COCH2CH2CI 119 F COOH 120 F COOCH3 121 F COOCH2CH3 122 F COOCH(CH3)2 123 F COOCH2CH=CH2 124 F COO(CH2)sCH3 125 F COOCH(CH3)CH=CH2 126 F COOCH2(2-F-C6H5) 127 F COOC6Hs 128 F COOCH2CH2OCH2CH3 129 F COOCH(CH3)CH2SCH3 130 F COO(oxetanyl) 131 F COO0H2(oxiranyl) 132 F COO(cylopentyl) 133 F COSCH3 134 F COSCH(CH3)2 Comp.No. R11 R13 In n = 1-34 135 F COSCH2C6H5 136 F CONH2 137 F CONH(CH2CH=CH2) 138 F CONHCH2C6H5 139 F CON(CH2CH=CH2)2 140 F CON(CH3)0CH3 141 F COOCH2CH2COOH 142 F COOCH(CH3)COOCH3 143 F COOCH(CH3)COOCH2C6H5 144 F COOCH(CH3)CH2COOCH2CH3 145 F (S)-COOCH (CH3)CH2COOCH2CH =CH2 146 F (R)-COOCH(CH3)CH2COOCH2CH=CH2 147 F COOCH(CH3)CH2CONHCH2CH3 148 F COOCH(CH3)CH2CON(CH3)2 149 F COOCH(CH3)CH2COSCH2CH3 150 F CooCH(CH3)CH2COOCH2CH=CH2 151 F COOC(CH3)2COCH3 152 F COOC(CH3)2COOH 153 F COOC(CH3)2COOCH3 154 F COOC(CH3)2COOCH2CH3 155 F COOC(CH3)2COOCH(CH3)2 156 F COOC(CH3)2COO(CH2)4CH3 157 F COOC(CH3)2COOCH2C6H5 158 F COOC(CH3)2COOCH2(2-F-C6H5) 159 F COOC(CH3)2COOCH2CH=CH2 160 F COOC(CH3)2COOCH(CH3)CH=CH2 161 F COOC(CH3)2COOCH2C=CH 162 F COO(CH3)2COOCH2CH20CH2CH3 163 F COOC(CH3)2COSCH3 164 F COOC(CH3)2COSCH(CH3)2 Comp.No. R11 R13 In n = 1-34 165 F COOC(CH3)2COSCH2C6H5 166 F COOC(CH3)2CONH2 167 F COOC(CH3)2CONHCH2CH=CH2 168 F COOC(CH3)2CON(CH2CH3)2 169 F COOC(CH3)2CON(CH3)CH2CH2 OCH3 170 F COSCH(CH3)COOH 171 F COSCH(CH3)COOCH3 172 F CoSCH(CH3)CONHCH2CH=CH2 173 F CON(CH3)CH2COOH 174 F CON(CH3)C(CH3)2COOCH2CH3 175 F CON(CH3)OCH2COOCH3 176 F CON(CH3)0H 177 F CH3 178 F CH2CH3 179 F CH(OH)CH3 180 F CH(OCH2CH=CH2)CH3 181 F CH2CI 182 F CH20H 183 F CH20COCH3 184 F CHCICH3 185 F CH2CH2CF3 186 F CH=CHCF3 187 F CH2CH=CH2 188 F CH=CHCH3 189 F C#CH 190 F CCCH20H 191 F CH2CHCICOOH 192 F (R)-CH2CHCICOOH 193 F (S)-CH2CHCICOOH 194 F CH2CH(CH3)COOH Comp.No. R11 R13 In n = 1-34 195 F CH2CH(CH3)COOCH2CH3 196 F CH(CI)CH2COOCH3 197 F CH(CI)C(CI)2COOH 198 F CH(CI)CH(CI)COOCH2CH3 199 F CH2CH(CH3)COOH 200 F CH2CH(CH3)COCH2CH=CH2 201 F CH2CH(CH3)CONH(CH2CH=CH2) 202 F CH2CH(CH3)CON(CH3)2 203 F CH2CH(CH3)COSCH(CH3)2 204 F CH2CHCICOOC(CH3)3 205 F CH2CHCICOOCH3 206 F CH2CHCICOOCH2CH3 207 F CH2CHCICOOCH(CH3)2 208 F CH2CHCICOOCH2CH=CH2 209 F CH2CHOlCOOCH2C6H5 210 F CH2CHCICOSCH3 211 F CH2CHCICOSCH(CH3)2 212 F CH2CHClCOSCH2C6H5 213 F CH2CHCICONH2 214 F CH2CHClCONH(CH2CH=CH2) 215 F CH2CHCICON(CH2CH3)2 216 F CH2CHCICONH(CH2C6Hs) 217 F CH2CHCICON(CH3)CH2C6Hs 218 F CH=CHCOOH 219 F (E)-CH=CHCOOH 220 F (Z)-CH=CHCOOH 221 F CH=CHCOOCH3 222 F CH=CHCOOCH2C6Hs 223 F CH=CHCONH2 224 F CH=CHCONH(CH2CH=CH2) Comp.No. R11 R13 In n = 1-34 225 F CH=C(CI)COOH 226 F CH=C(CI)CONH2 227 F CH=C(Cl)CONH(CH2CH3) 228 F CH=C(CI)CON(CH2CH3)2 229 F CH=C(Cl)CONH(CH2C6H5) 230 F CH=C(CI)COSCH3 231 F CH=C(Cl)COSCH(CH3)2 232 F CH=C(CH3)COOH 233 F CH=C(CH3)CONH(CH2CH=CH2) 234 F CH=C(CH3)CON(CH3)2 235 F CH=C(CH3)COSCH2CH3 236 F CH=C(CN)COOH 237 F CH=C(CN)COOC(CH3)3 238 F CH=C(CN)CON(CH2CH=CH2)2 239 F CH=C(COOH)2 240 F CH=C(C6H5)COOH 241 F CH=CHCH2OH 242 CI F 243 Cl H 244 Cl Cl 245 Cl NH2 246 Cl OH 247 Cl SH 248 CI Br 249 CI I 250 Cl CN 251 Cl SO2Cl 252 CI NH(CH3) 253 Cl N(CH2CH3)2 254 Cl NH(COCH3) Comp.No. R11 R13 in n = 1-34 255 Cl NH(CH2CH=CH2) 256 Cl N(CH3)(CH2C=CH) 257 CI N(So2CH3)2 258 Cl NH(SO2CH2CH3) 259 Cl N(CH2CH=CH2)(SO2CH2CH3) 260 Cl N(CH2C=CH)(SO2CH(CH3)2) 261 Cl N(CH2CF3)(CHO) 262 Cl NH(CH2C6H5) 263 Cl OCH3 264 Cl OCH2CH3 265 Cl OCH(CH3)2 266 Cl OCH(CH3)CH2CH2CH3 267 Cl OCH2CH=CH2 268 Cl OCH(CH3)CH=CH2 269 Cl OCH2CCH 270 Cl OCH(CH3)C=CH 271 Cl OCH(cyclopentyl) 272 CI OCH2(C6H5) 273 Cl OCH2(2-F-C6H5) 274 Cl OCH(CH3)(4-CH3-C6H5) 275 Cl OC6H5 276 Cl 0(4-pyrimidyl) 277 Cl OCH2CH2Cl 278 CI OCH2CH=CHCI 279 Cl OCH2CH2OH 280 Cl OCH2OCH3 281 Cl OCH2CH20CH2CH3 282 Cl OCH2CH2OCH2CH2OCH2CH3 283 Cl OCH(CH3)CH2OCH2CH2=CH2 284 Cl OCOCH3 Comp.No. R11 R13 In n=1-34 285 Cl OCOOCH3 286 Cl OCOCH2C6H5 287 Cl OCH2SCH3 288 CI OCH2CH2SCH2CH3 289 Cl OCH2COOH 290 Cl OCH(CH3)COOH 291 Cl (R)-OCH(CH3)COOH 292 Cl (S)-OCH(CH3)COOH 293 Cl OCH2COOCH2CH3 294 Cl OCH(CH3)COOCH3 295 Cl OCH(CH3)COOCH2CH=CH2 296 Cl OCH(CH3)COOCH2(C6H5) 297 CI OCH(CH3)CH2COOH 298 Cl OCH(CH3)CH2COOCH2CH3 299 Cl OCH2COSCH3 300 Cl OCH(CH3)COSCH2CH3 301 Cl OCH(CH3)COSCH(CH3)2 302 Cl OCH2CONH2 303 Cl OCH2CON(CH2CH3)2 304 Cl OCH(CH3)CON(CH3)2 305 Cl OCH(CH3)CONH(CH2CH=CH2) 306 Cl OCH(CH3)CON(CH3)(CH2C#CH) 307 Cl OCH(CH3)CON(CH2C6H5)2 308 Cl OCH(CH3)CON(CH3)(C6H5) 309 Cl OCH2COOCH2CH2SCH3 310 Cl OCH(CH(CH3)2)COOH 311 Cl OCH(CH3)COOCH2CH2OCH2CH3 312 Cl OCH(C6H5)COOH 313 Cl (R)-OCH(C6H5)COOH 314 CI (S)-OCH(C.Hs)COOH Comp.No. R11 R13 In n = 1-34 315 Cl OCH(C6H5)COOCH3 316 Cl OCH(C6H5)COOCH(CH3)C#CH 317 Cl OCH(C6H5)COOCH2C6H5 318 Cl OCH(C6H5)COSCH(CH3)2 319 Cl OCH(C6H5)CONH2 320 Cl OCH(C6H5)CONH(CH2C#CH) 321 CI OCH(C6H5)CON(CH2CH=CH2)2 322 Cl OCH(C6H5)CON(CH3)CH2C6H5 323 Cl oCH(C6H5)CoNH(CH2(2-F-C6Hd) 324 Cl OCH(C6H6)CONH (cyclopropyl) 325 Cl OCH2CH2COOH 326 CI OCH2CH2COOCH2CH3 327 CI OCH(CH3)CH2COOH 328 Cl SCH3 329 CI SCH(CH3)2 330 Cl SCH2CH=CH2 331 CI SCH2C6H5 332 CI SCH2CH2OCH3 333 Cl SC6H5 334 CI SCH2COOH 335 Cl SCH2COOCH2C6H5 336 Cl SCH(CH3)COOH 337 CI SCH(CH3)COOCH2CH9 338 Cl SCH(CH3)COOCH2CH=CH2 339 CI SCH(CH3)COSCH3 340 Cl SCH(CH3)CON(CH3)2 341 Cl SCH(CH3)CONH(CH2CH=CH2) 342 Cl SOCH2CH3 343 Cl SO2CH3 344 CI S02NH2 Comp.No. R11 R13 In n = 1-34 345 Cl SO2N(0H3)2 346 Cl SO2N(CH2CH3)2 347 Cl SO2N(CH3)(CH2(4-CH3-C6H5)) 348 CI SO2NHCH2CH20CH3 349 Cl SCOOCH3 350 Cl SCON(CH3)2 351 CI SCONHCH2CH=CH2 352 Cl SCOOCH2CH=CH2 353 Cl SCON(CH2CH3)COCF3 354 CI CHO 355 Cl 000H3 356 Cl 0000H20H3 357 CI 0000H206H5 358 CI COCI 359 Cl 000H20H2CI 360 CI COOH 361 CI COOCH3 362 Cl COOCH2CH3 363 Cl COOCH(CH3)2 364 Cl COOCH2CH=CH2 365 Cl COO(CH2)5CH3 366 Cl COOCH(CH3)CH=CH2 367 Cl COOCH2(2-F-C6H5) 368 Cl COOC6H5 369 Cl COOCH2CH2OCH2CH3 370 Cl COOCH(CH3)CH2SCH3 371 Cl COO(oxetanyl) 372 Cl COOCH2(oxiranyl) 373 Cl COO(cylopentyl) 374 Cl COSCH3 Comp.No. R11 R13 in n=1-34 375 CI COSCH(CH3)2 376 Cl COSCH2C6H5 377 Cl CONH2 378 Cl CONH(CH2CH=CH2) 379 CI CONHCH2C6H5 380 Cl CON(CH2CH=CH2)2 381 Cl CON(CH3)0CH3 382 CI COOCH2CH2COOH 383 Cl COOCH(CH3)COOCH3 384 Cl COOCH(CH3)COOCH2C6H5 385 Cl COOCH(CH3)CH2COOCH2CH3 386 Cl (S)-COOCH(CH3)CH2COOCH2CH=CH2 387 Cl (R)-COOCH(CH3)CH2COOCH2CH=CH2 388 Cl COOCH(CH3)CH2CONHCH2CH3 389 Cl COOCH(CH3)CH2CON(CH3)2 390 Cl COOCH(CH3)CH2COSCH2CH3 391 Cl COOCH(CH3)CH2COOCH2CH=CH2 392 Cl COOC(CH3)2COCH3 393 Cl COOC(CH3)2COOH 394 Cl COOC(CH3)2COOCH3 395 Cl COOC(CH3)2COOCH2CH3 396 Cl COOC(CH3)2COOCH(CH3)2 397 Cl COOC(CH3)2COO(CH2)4CH3 398 Cl COOC(CH3)2COOCH2C6H5 399 Cl COOC(CH3)2COOCH2(2-F-C6H5) 400 Cl COOC(CH3)2COOCH2CH=CH2 401 Cl COOC(CH3)2COOCH(CH3)CH=CH2 402 Cl COOC(CH3)2COOCH2C.CH 403 Cl COO(CH3)2COOCH2CH2OCH2CH3 404 Cl COOC(CH3)2COSCH3 Comp.No. R11 R13 In n = 144 405 Cl COOC(CH3)2COSCH(CH3)2 406 CI COOC(CH3)2COSCH2C6Hs 407 Cl COOC(CH3)2CONH2 408 Cl COOC(CH3)2CONHCH2CH=CH2 409 Cl COOC(CH3)2CON(CH2CH3)2 410 Cl COOC (CH3)2CON (CH3)CH2CH20CH3 411 Cl COSCH(CH3)COOH 412 Cl COSCH(CH3)COOCH3 413 CI CoSCH(CH3)CONHCH2CH=CH2 414 Cl CON(CH3)CH2COOH 415 Cl CON(CH3)C(CH3)2COOCH2CH3 416 Cl CON(CH3)0CH2COOCH3 417 Cl CON(CH3)0H 418 CI CH3 419 Cl CH2CH3 420 CI CH(OH)CH3 421 Cl CH(OCH2CH=CH2)CH3 422 Cl CH2CI 423 Cl CH20H 424 Cl CH2OCOCH3 425 Cl CHClCH3 426 CI CH2CH2CF3 427 CI CH=CHCF3 428 Cl CH2CH=CH2 429 Cl CH=CH(CH3) 430 Cl C#CH 431 Cl C.CCH20H 432 CI CH2CHCICOOH 433 CI (R)-CH2CHCICOOH 434 Cl (S)-CH2CHClCOOH Comp.No. R11 R13 In n=1-34 435 CI CH2CH(CH3)COOH 436 CI CH2CH(CH3)COOCH2CH3 437 Cl CH(Cl)CH2COOCH3 438 Cl CH(Cl)C(Cl)2COOH 439 Cl CH(Cl)CH(Cl)COOCH2CH3 440 CI CH2CH(CH3)COOH 441 Cl CH2CH(CH3)COCH2CH=CH2 442 Cl CH2CH(CH3)CONH(CH2CH=CH2) 443 Cl CH2CH(CH3)CON(CH3)2 444 Cl CH2CH(CH3)COSCH(CH3)2 445 Cl CH2CHClCOOC(CH3)3 446 Cl CH2CHCICOOCH3 447 CI CH2CHCICOOCH2CH3 448 CI CH2CHCICOOCH(CH3)2 449 CI CH2CHCICOOCH2CH=CH2 450 Cl CH2CHCICOOCH2C6H5 451 Cl CH2CHCICOSCH3 452 Cl CH2CHCICOSCH(CH3)2 453 Cl CH2CHCICOSCH2C6H5 454 Cl CH2CHCICONH2 455 Cl CH2CHClCONH(CH2CH=CH2) 456 Cl CH2CHClCON(CH2CH3)2 457 Cl CH2CHClCONH(CH2C6H5) 458 CI CH2CHCICON(CH3)CH2C6H5 459 CI CH=CHCOOH 460 Cl (E)-CH=CHCOOH 461 Cl (Z)-CH=CHCOOH 462 Cl CH=CHCOOCH3 463 CI CH=CHCOOCH2C6H5 464 Cl CH=CHCOONH2 Comp.No. R11 R13 In n=1-34 465 Cl CH=CHCONH(CH2CH=CH2) 466 Cl CH=C(Cl)COOH 467 Cl CH=C(Cl)CONH2 468 Cl CH=C(CI)CONH(CH2CH3) 469 Cl CH=C(Cl)CON(CH2CH3)2 470 Cl CH=C(CI)CONH(CH2C6H5) 471 CI CH=C(CI)COSCH3 472 Cl CH=C(Cl)COSCH(CH3)2 473 Cl CH=C(CH3)COOH 474 Cl CH=C(CH3)CONH(CH2CH=CH2) 475 Cl CH=C(CH3)CON(CH3)2 476 Cl CH=C(CH3)COSCH2CH3 477 Cl CH=C(CN)COOH 478 Cl CH=C(CN)COOC(CH3)3 479 Cl CH=C(CN)CON(CH2CH=CH2)2 480 CI CH=C(COOH)2 481 Cl CH=C(C6H5)COOH 482 Cl CH=CHCH2OH 483 H F 484 H H 485 H CI 486 H Br 487 H 488 H NH2 489 H OH 490 H SH 491 H SO2Cl 492 H CN 493 H NH(CH2C6H5) 494 H N(CH2CH=CH2)2 Comp.No. R11 R13 In n=1-34 495 H N(S020H3)2 496 H NH(SO2CH2CH3 497 H NH(COCH3) 498 H OCH3 499 H OCH2CH3 500 H OCH2CH=CH2 501 H OCH2C#CH 502 H OCH2C6H5 503 H OCH2CH2CI 504 H OCH2CH20H 505 H OCH20CH3 506 H OCH2CH20CH2CH3 507 H OCH2CH20CH2CH20CH3 508 H OCOCH3 509 H OCOOCH3 510 H OCH2SCH3 511 H OCH2CH2SCH3 512 H OCH2COOH 513 H OCH2COOCH3 514 H OCH2COOCH2C6H5 515 H OCH2CONH(CH3) 516 H OCH(CH3)COOH 517 H OCH(CH3)COOCH2CH3 518 H OCH(CH3)COOCH2CH=CH2 519 H OCH(CH3)COOCH2C6H5 520 H OCH(CH3)CONH2 521 H OCH(CH3)CONH(CH2CH=CH2) 522 H OCH(CH3)CON(CH3)2 523 H OCH(CH3)COSCH(CH3)2 524 H OCH(C6H5)COOH Comp.No. R11 R13 In n = 1-34 525 H OCH(C6Hs)COOCH3 526 H OCH(C6H5)COOCH2CH=CH2 527 H OCH(C6H5)CONH2 528 H OCH(C6H5)CONH(CH2CH3) 529 H OCH(C6H5)CON(CH3)2 530 H OCH(C6Hs)COSCH3 531 H OCH(C6H5)COSCH(CH3)2 532 H OCH(CH3)CH2COOH 533 H OCH(CH3)CH2COOCH2CH3 534 H SCH3 535 H SCH(CH3)2 536 H SCH2C6H5 537 H SCH(CH3)COOH 538 H SCH(CH3)COOCH2CH3 539 H S02NH2 540 H SO2NH(CH2CH=CH2) 541 H S02N(CH3)2 542 H SCOCH3 543 H SCOOCH2CH3 544 H CH2OCOCH3 545 H COOH 546 H COCI 547 H COOCH3 548 H COOCH(CH3)2 549 H COOCH2C6H5 550 H COSCH(CH3)2 551 H CONH2 552 H CONHCH2C6H5 553 H CON(CH2CH=CH2)2 554 H CON(CH3)OCH3 Comp.No. R11 R13 In n=1-34 555 H COOCH(CH3)CH2COOH 556 H COOCH(CH3)COOCH2CH3 557 H COOCH(CH3)CH2COOCH2CH=CH2 558 H COOCH(CH3)CH2COSCH2CH3 559 H COOCH(CH3)CH2CONH2 560 H COOCH(CH3)CH2CONH(CH2CH=CH2) 561 H COOCH(CH3)COOH 562 H COOC(CH3)2COOH 563 H COOC(CH3)2COOCH3 564 H COOC(CH3)2COOCH(CH3)2 565 H COOC(CH3)2COOCH2CH3 566 H COOC(CH3)2COOCH2CH=CH2 567 H COOC(CH3)2COOCH2CH2OCH2CH3 568 H COOC(CH3)2CONH2 569 H COOC(CH3)2CON(CH3)2 570 H COOC(CH3)2CONH(CH2CH=CH2) 571 H COSCH(CH3)COOH 572 H CON(CH3)C(CH3)2COOH 573 H CH3 574 H CH2CH3 575 H CH(OH)CH3 576 H CH2CI 577 H CH2OH 578 H CH2OCOCH3 579 H CH=CHCF3 580 H CH2CH2CF3 581 H CH2CH=CH2 582 H CH2CHCICOOH 583 H CH2CHCICOOCH2CH3 584 H CHzCHCICOOCH2C6H5 Comp.No. R11 R13 In n=1-34 585 H CH2CHClCOOCH2CH=CH2 586 H CH2CHCICOOC(CH3)3 587 H CH2CHClCOSCH(CH3)2 588 H CH2CHCICONH2 589 H CH2CHClCONH(CH2CH3) 590 H CH2CHCICON(CH3)2 591 H CH(CI)CH(CI)COOH 592 H CH2C(CH3)CICOOH 593 H CH2C(CH3)CICOOCH2CH3 594 H CH2C(CH3)ClCOSCH3 595 H CH2C(CH3)ClOONH(OH2CH=0H2) 596 H CH2C(CH3)ClCON(CH3)(CH2CH=CH2) 597 H CH=CHCOOH 598 H CH=C(CH3)COOH 599 H CH=C(Cl)COOH 600 H CH=C(CN)COOH 601 H CH=C(CN)COOCH2CH=CH2 602 H CH=C(CI)COOCH2CH3 603 H CH=C(CH3)CONH(CH2CH=CH2) 604 H CH=C(Cl)COSCH2CH3 605 H CH=C(CI)CON(CH3)2 606 CH3 F 607 CH3 H 608 CH3 Cl 609 CH3 Br 610 CH3 611 CH3 NH2 612 CH3 OH 613 CH3 SH 614 CH3 SO2Cl Comp.No. R11 R13 In n = 1-34 615 CH3 CN 616 CH3 NH(CH2C6H5) 617 CH3 N(CH2CH=CH2)2 618 CH3 N(S02CH3)2 619 CH3 NH(S02CH2CH3 620 CH3 NH(COCH3) 621 CH3 OCH3 622 CH3 OCH2CH3 623 CH3 OCH2CH=CH2 624 CH3 OCH2C#CH 625 CH3 OCH2C6H5 626 CH3 OCH2CH2CI 627 CH3 OCH2CH2OH 628 CH3 OCH20CH3 629 CH3 OCH2CH20CH2CH3 630 CH3 OCH2CH2OCH2CH2OCH3 631 CH3 OCOCH3 632 CH3 OCOOCH3 633 CH3 OCH2SCH3 634 CH3 OCH2CH2SCH3 635 CH3 OCH2COOH 636 CH3 OCH2COOCH3 637 CH3 OCH2COOCH2C6H5 638 CH3 OCH2CONH(CH3) 639 CH3 OCH(CH3)COOH 640 CH3 OCH(CH3)COOCH2CH3 641 CH3 OCH(CH3)COOCH2CH=CH2 642 CH3 OCH(CH3)COOCH2C6H5 643 CH3 OCH(CH3)CONH2 644 CH3 OCH(CH3)CONH(CH2CH=CH2) Comp.No. R11 R13 In n = 144 645 CH3 OCH(CH3)CON(CH3)2 646 CH3 OCH(CH3)COSCH(CH3)2 647 CH3 OCH(C6H5)COOH 648 CH3 OCH(C6Hs)COOCH3 649 CH3 OCH(C6H5)COOCH2CH=CH2 650 CH3 OCH(C6H5)CONH2 651 CH3 OCH(C6H5)CONH(CH2CH3) 652 CH3 OCH(C6H5)CON(CH3)2 653 CH3 OCH(C6H5)COSCH3 654 CH3 OCH(C6H5)COSCH(CH3)2 655 CH3 OCH(CH3)CH2COOH 656 CH3 OCH(CH3)CH2COOCH2CH3 657 CH3 SCH3 658 CH3 SCH(CH3)2 659 CH3 SCH2C6H5 660 CH3 SCH(CH3)COOH 661 CH3 SCH(CH3)COOCH2CH3 662 CH3 SO2NH2 663 CH3 SO2NH(CH2CH=CH2) 664 CH3 SO2N(CH3)2 665 CH3 SCOCH3 666 CH3 SCOOCH2CH3 667 CH3 CH20COCH3 668 CH3 COOH 668 CH3 COCI 670 CH3 COOCH3 671 CH3 COOCH(CH3)2 672 CH3 COOCH2C6H5 673 CH3 COSCH(CH3)2 674 CH3 CONH2 Comp.No. R 11 R13 In n = 1-34 675 CH3 CONHCH2C6H5 676 CH3 CON(CH2CH=CH2)2 677 CH3 CON(CH3)0CH3 678 CH3 COOCH(CH3)CH2COOH 679 CH3 COOCH(CH3)COOCH2CH3 680 CH3 COOCH(CH3)CH2COOCH2CH=CH2 681 CH3 COOCH(CH3)CH2COSCH2CH3 682 CH3 COOCH(CH3)CH2CONH2 683 CH3 COOCH(CH3)CH2CONH(CH2CH=CH2) 684 CH3 COOCH(CH3)COOH 685 CH3 COOC(CH3)2COOH 686 CH3 COOC(CH3)2COOCH3 687 CH3 COOC(CH3)2COOCH(CH3)2 688 CH3 COOC(CH3)2COOCH2CH3 689 CH3 COOC(CH3)2COOCH2CH=CH2 690 CH3 COOC(CH3)2COOCH2CH2OCH2CH3 691 CH3 COOC(CH3)2CONH2 692 CH3 COOC(CH3)2CON(CH3)2 693 CH3 COOC(CH3)2CONH(CH2CH=CH2) 694 CH3 COSCH(CH3)COOH 695 CH3 CON(CH3)C(CH3)2COOH 696 CH3 CH3 697 CH3 CH2CH3 698 CH3 CH(OH)CH3 699 CH3 CH2CI 700 CH3 CH20H 701 CH3 CH20COCH3 702 CH3 CH=CHCF3 703 CH3 CH2CH2CF3 704 CH3 CH2CH=CH2 Comp.No R11 R13 In n=1-34 705 CH3 CH2CHClCOOH 706 CH3 CH2CHCICOOCH2CH3 707 CH3 CH2CHCICOOCH2C6Hs 708 CH3 CH2CHCICOOCH2CH=CH2 709 CH3 CH2CHCICOOC(CH3)3 710 CH3 CH2CHCICOSCH(CH3)2 711 CH3 CH2CHCICONH2 712 CH3 CH2CHClCONH(CH2CH3) 713 CH3 CH2CHClCON(CH3)2 714 CH3 CH(CI)CH(CI)COOH 715 CH3 CH2C(CH3)ClCOOH 716 CH3 CH2C(CH3)CICOOCH2CH3 717 CH3 CH2C(CH3)CICOSCH3 718 CH3 CH2C(CH3)ClCONH(CH2CH=CH2) 719 CH3 CH2C(CH3)CICON(CH3)(CH2CH=CH2) 720 CH3 CH=CHCOOH 721 CH3 CH=C(CH3)COOH 722 CH3 CH=C(CI)COOH 723 CH3 CH=C(CN)COOCH2CH=CH2 724 CH3 CH=C(CN)COOH 725 CH3 CH=C(CI)COOCH2CH3 726 CH3 CH=C(CH3)CONH(CH2CH=CH2) 727 CH3 CH=C(CI)COSCH2CH3 728 CH3 CH=C(CI)CON(CH3)2 729 H N-imidazolyl 730 F N-imidazolyl 731 Cl N-imidazolyl 732 CH3 N-imidazolyl 733 H COOCH2CH3 734 CH3 COOCH2CH3 Comp.No. R11 R13 In n=1-34 735 F N(CH3)2 736 F OCH2CH2OCH2CH2OCH3 737 F OCH2COOCH2CH3 738 F OCH(CH3)COOCH2CH3 739 F OCH2CH(OH)CH20H 740 F CH=CH2 741 F COSCH2CH3 742 F COO +NH2(CH(CH3)2)2 743 F COO- +NH(CH2CH2OH)3 744 F COO +K 745 F OCH2COOC(CH3)3 746 F OCH2CH2C6H5 747 F N(CH2C#CH)(SO2CH2CH3) 748 F OCH2CH2CH2CH3 749 F OCH(C6H5)COOCH2CH3 750 F OCH2CH2CH2COOCH2CH3 751 F COOCH2CH(CH3)CF3 752 F COOCH(CH3)COOCH2CH3 753 F CON(CH2CH2CH3)2 754 F COOCH2CH2CH2CH2CH3 755 F COOCH2CH2SCH2CH2CH2CH3 756 F COOCH2CH2CN 757 F COOCH2CH2SCH(CH3)2 758 F COOCH2CH2CH2C6H5 759 F COOCH(CH3)CH2CH2CH3 760 F COO(CH2)sCOOCH2CH3 761 F COOC(CH3)3 762 F OCH2CH2CH3 763 F OCH2CH=CHCI 764 F CH=C(CH3)COOCH2CH3 Comp.No. R11 R13 In n=1-34 765 F COO-cyclopropyl 766 F C00-cyclohexyl 767 F COOCH2-cyclopropyl 768 F COOCH2C6Hs 769 F COOCH2CH20CH3 770 F COOCH2CH2CH3 771 F COOCH2CH(CH3)2 772 F COOCH2CH2CH2CH3 773 F COOCH2CH(CH3)CH2CH3 774 F COOCH2(p-Cl-C6H4) 775 F COOCH(CH3)C6H5 776 F COSCH2(o-F-C6H4) 777 F COSCH(CH3)CH2CH3 778 F COSCH(CH3)C6H5 779 F COSCH2CH2CH3 780 F COSCH2CH=CH2 781 F CON(CH2CH=CH2)CH2CH3 782 F CON(SO2CH3)CH3 783 F CON(SO2CH3)CH2CH=CH2 784 Cl C00-cyclopropyl 785 Cl C00-cyclohexyl 786 CI COOCH2-cyclopropyl 787 Cl COOCH2C6H5 788 CI COOCH2CH2OCH3 789 CI COOCH2CH2CH3 790 Cl COOCH2CH(CH3)2 791 CI COOCH2CH2CH2CH3 792 Cl COOCH2CH(CH3)CH2CH3 793 CI COOCH2(p-CI-C6H4) 794 Cl COOCH(CH3)C6Hs Comp.No. R11 R13 In n = 1-34 795 CI COOCH(CH3)CsH5 796 Cl COSCH2(o-F-C6H4) 797 Cl COSCH(CH3)CH2CH3 798 Cl COSCH(CH3)CsHs 799 Cl COSCH2CH2CH3 800 Cl COSCH2CH=CH2 801 Cl CON(CH2CH=CH2)CH2CH3 802 Cl CON(SO2CH3)CH3 803 Cl CON(SO2CH3)CH2CH=CH2 804 H COOC(CH3)2COCl 805 F CH=C(F)COOCH2CH3 (E/Z) 806 F CH=C(Cl)COOCH2CH3 (E/Z) 807 F OCH2COOCH2C6H5 808 F OCH2CN Table 2: Compounds of the formulae I35-I67, 1147, I148 Comp.No. R3 R11 R13 In n=35-67, 147, 148 001 Cl H H 002 Br H H 003 NH2 H H 004 NH(CH2CH3) H H 005 N(CH2C#CH)2 H H 006 N(CH3)(CH2CH=CH2) H H Comp.No. R3 R ii R 13 In n=3547, 147, 148 007 NH(CH2C6H5) H H 008 -ND H H 009 NHOOOH3 H H 010 NHCOCH2CH3 H H 011 NHCOCHCICH3 H H 012 NHCOCH2CI H H 013 NHCOCHCI2 H H 014 N(CH3)COCHCI2 H H 015 N(CH2C.CH)COCHC12 H H 016 NHCOCF3 H H 017 N(COCF3)2 H H 018 NHCOCF2CF3 H H 019 NHCOCCIF2 H H 020 NHCOCF2CF2CF3 H H 021 NHCO(2-thienyl) H H 022 NHCO(3-furanyl) H H 023 NHCO(3-tetrahydrofuranyl) H H 024 NHCO(2-furanyl) H H 025 NHCO(2-tetrahydrofuranyl) H H 026 NHSO2CH3 H H 027 N(SO2CH3)2 H H 028 NHSO2CH2CH3 H H 029 N(CH2CCH)SO2CH2CH3 H H 030 NHSO2CF3 H H 031 Cl Cl H 032 I Br Cl H 033 NH2 Cl H 034 NH(CH2CH3) CI H Comp.No. R3 R R13 In n=3547, 147, 148 035 N(CH2CCCH)2 Cl H 036 N(CH3)(CH2CH=CH2) Cl H 037 NH(CH2C6H5) CI H 038 -ND Cl H 039 NHCOCH3 Cl H 040 NHCOCH2CH3 Cl H 041 NHCOCHCICH3 Cl H 042 NHCOCH2CI Cl H 043 NHCOCHCI2 Cl H 044 N(CH3)COCHC12 Cl H 045 N(CH2C-CH)COCHC12 Cl H 046 NHCOCF3 CI H 047 N(COCF3)2 Cl H 048 NHCOCF2CF3 Cl H 049 NHCOCCIF2 Cl H 050 NHCOCF2CF2CF3 CI H 051 NHCO(2-thienyl) CI H 052 NHCO(3-furanyl) Ol H 053 NHOO(3-tetrahydrofuranyl) Cl H 054 NHCO(2-furanyl) Cl H 055 NHOO(2-tetrahydrofuranyl) CI H 056 NHSO2CH3 CI H 057 N(S020H3)2 Ol H 058 NHSO2CH2CH3 CI H 059 N(CH2C.CH)SO2CH2CH3 Cl H 060 NHSO2OF3 Cl H 061 Cl CH3 H 062 Br CH3 H Comp.No. R3 R11 R13 In n = 35w67, 147, 148 063 NH2 CH3 H 064 NH(CH2CH3) CH3 H 065 N(CH2C CH)2 CH3 H 066 N(CH3)(CH2CH=CH2) CH3 H 067 NH(CH2C6Hs) CH3 H 068 -ND CH3 H 069 NHCOCH3 CH3 H 070 NHCOCH2CH3 CH3 H 071 NHCOCHCICH3 CH3 H 072 NHCOCH2CI CH3 H 073 NHCOCHC12 CH3 H 074 N(CH3)COCHC12 CH3 H 075 N(CH2C.CH)COCHC12 CH3 H 076 NHCOCF3 CH3 H 077 N(COCF3)2 CH3 H 078 NHCOCF2CF3 CH3 H 079 NHCOCCIF2 CH3 H 080 NHCOCF2CF2CF3 CH3 H 081 NHCO(2-thienyl) CH3 H 082 NHCO(3-furanyl) CH3 H 083 NHOO(3-tetrahydroturanyl) CH3 H 084 NHCO(2-furanyl) CH3 H 085 NHCO(2-tetrahydrofuranyl) CH3 H 086 NHSO2CH3 CH3 H 087 N(S020H3)2 CH3 H 088 NHSO2CH2CH3 CH3 H 089 N(CH2C.CH)SO2CH2CH3 CH3 H 090 NHSO2CF3 CH3 H Comp.No. R5 R11 R13 In n=3547, 147, 148 091 CI F H 092 Br F H 093 NH2 F H 094 NH(CH2CH3) F H 095 N(CH2CSCH)2 F H 096 N(CH3)(CH2CH=CH2) F H 097 NH(CH2C6H5) F H 098 -ND F H 099 NHCOCH3 F H 100 NHCOCH2CH3 F H 101 NHCOCHCICH3 F H 102 NHCOCH2CI F H 103 NHCOCHCI2 F H 104 N(CH3)COCHC12 F H 105 N(CH2C.CH)COCHC12 F H 106 NHCOCF3 F H 107 N(COCF3)2 F H 108 NHCOCF2CF3 F H 109 NHCOCCIF2 F H 110 NHCOCF2CF2CF3 F H 111 NHCO(2-thienyl) F H 112 NHCO(3-furanyl) F H 113 NHOO(3-tetrahydrofuranyl) F H 114 NHCO(2-furanyl) F H 115 NHCO(2-tetrahydrofuranyl) F H 116 NHSO2CH3 F H 117 N(S020H3)2 F H 118 NHSO2CH2CH3 F H Comp.No. R3 R11 R13 In n=3547, 147, 148 119 N(CH2CCH)SO2CH2CH3 F H 120 NHSO2CF3 F H 121 Cl CI F 122 Br Cl F 123 NH2 Cl F 124 NH(CH2CH3) Cl F 125 N(CH2C-CH)2 Cl F 126 N(CH3)(CH2CH=CH2) Cl F 127 NH(CH2C6Hs) CI F 128 ND Cl F 129 NHCOCH3 CI F 130 NHCOCH2CH3 CI F 131 NHCOCHCICH3 CI F 132 NHCOCH2CI CI F 133 NHCOCHCI2 CI F 134 N(CH3)COCHC12 Cl F 135 N(CH2C-CH)COCHCI2 CI F 136 NHCOCF3 Cl F 137 N(COCF3)2 CI F 138 NHCOCF2CF3 Cl F 139 NHCOCCIF2 Cl F 140 NHCOCF2CF2CF3 Cl F 141 NHCO(2-thienyl) Cl F 142 NHCO(3-furanyl) Cl F 143 NHOO(3-tetrahydrofuranyl) Cl F 144 NHCO(2-furanyl) Cl F 145 NHCO(2-tetrahydrofuranyl) CI F 146 NHSO2CH3 CI F Comp.No. R 3 R11 R13 In n=35-67, 147, 148 147 N(SO2CH3)2 Ol F 148 NHSO2CH2CH3 Cl F 149 N(CH2CCH)SO2CH2CH3 Cl F 150 NHSO2CF3 Cl F 151 Cl Br H 152 Br Br H 153 NH2 Br H 154 NH(CH2CH3) Br H 155 N(CH2CCH)2 Br H 156 N(CH3)(CH2CH=CH2) Br H 157 NH(CH2C6Hs) Br H 158 -ND Br H 159 NHCOCH3 Br H 160 NHCOCH2CH3 Br H 161 NHCOCHCICH3 Br H 162 NHCOCH2CI Br H 163 NHCOCHCI2 Br H 164 N(CHs)COCHCI2 Br H 165 N(CH2C.CH)COCHC12 Br H 166 NHCOCF3 Br H 167 N(COCF3)2 Br H 168 NHCOCF2CF3 Br H 169 NHCOCCIF2 Br H 170 NHCOCF2CF2CF3 Br H 171 NHCO(2-thienyl) Br H 172 NHCO(3-furanyl) Br H 173 NH CO (3-tetrahydrofuranyl) Br H 174 NHCO(2-furanyl) Br H Comp.No. R3 R11 R13 In n=35-67, 147, 148 175 NHCO(2-tetrahydrofuranyl) Br H 176 NHSO2CH3 Br H 177 N(SO2CH3)2 Br H 178 NHSO2CH2CH3 Br H 179 N(CH2C.CH)SO2CH2CH3 Br H 180 NHSO2CF3 Br H 181 NH2 Cl Cl 182 NHCOCHCl2 Cl Cl 183 NHCOCH2CI Cl Cl 184 NH2 F Cl 185 NHCOCHCl2 F Cl Table 3: Compounds of the formulae I68-I106, I137-I146 Comp.No. R11 R13 In n=68-106, 137-146 001 F F 002 F H 003 F Cl Comp.No. R11 R13 In n = 68-106, 137-146 004 F NH2 005 F OH 006 F SH 007 F Br 008 F I 009 F CN 010 F SO2Cl 011 F NH(CH3) 012 F N(CH2CH3)2 013 F NH(COCH3) 014 F N (SO2CH3)2 015 F NH(SO2CH2CH3) 016 F N(CH2CH=CH2)(SO2CH2CH3) 017 F N(CH2CRCH)(S02CH(CH3)2) 018 F OCH3 019 F OCH2CH3 020 F OCH(CH3)2 021 F OCH2CHCH2 022 F OCH(CH3)CH=CH2 023 F OCH2C.CH 024 F OCH (cyclopentyl) 025 F OCH2(2-F-C6H5) 026 F OCH(CH3)(4-CH3-C6H5) 027 F OC6H5 028 F OCH2CH2CI 029 F OCH2CH=CHCI 030 F OCH2CH2OH 031 F OCH2OCH3 032 F OCH2CH2OCH2CHs Comp.No. R11 R13 In n=68-106, 137-146 033 F OCH2CH2OCH2CH2OCH2CH3 034 F OCH(CH3)CH2OCH2CH=CH2 035 F OCOCH3 036 F OCOOCH3 037 F OCOCH2C6H5 038 F OCH2SCH3 039 F OCH2COOH 040 F OCH(CH3)COOH 041 F OCH2COOCH2CH3 042 F OCH(CH3)COOCH3 043 F OCH(CH3)COOCH2CH=CH2 044 F OCH(CH3)COOCH2(C6H5) 045 F OCH(CH3)CH2COOH 046 F OCH(CH3)CH2COOCH2CH3 047 F OCH(CH3)COSCH2CH3 048 F OCH2CONH2 049 F OCH2CON(CH2CH3)2 050 F OCH(CH3)CON(CH3)2 051 F OCH(CH3)CONH(CH2CH=CH2) 052 F OCH(CH3)CON(CH3)(CH2C"CH) 053 F OCH(CH3)CON(CH3)(C6H5) 054 F OCH2COOCH2CH2SCH3 055 F OCH(CH(CH3)2)COOH 056 F OCH(CH3)COOCH2CH2OCH2CH3 057 F OCH(C6H5)COOH 058 F OCH(C6H5)COOCH3 059 F OCH(C6H5)COOCH(CH3)C=CH 060 F OCH(C6H5)COOCH2C6H5 061 F OCH(C6H5)COSCH(CH3)2 Comp.No R11 R13 In n = 68106, 137-146 062 F OCH(C6H5)CONH2 063 F OCH(C6H5)CONH(CH2C=CH) 064 F OCH(C6H5)CON(CH2CH=CH2)2 065 F OCH(C6H5)CON(CH3)CH2C6H5 066 F OCH (CsH5)CONH (cyclopropyl) 067 F OCH2CH2COOH 068 F OCH2CH2COOCH2CH3 069 F OCH(CH3)CH2COOH 070 F SCH3 071 F SCH(CH3)2 072 F SCH2CH=CH2 073 F SCH2C6H5 074 F SCH2CH2OCH3 075 F SCH2COOH 076 F SCH2COOCH2C6H5 077 F SCH(CH3)COOH 078 F SCH(CH3)COOCH2CH3 079 F SCH(CH3)COOCH2CH=CH2 080 F SCH(CH3)CON(CH3)2 081 F SCH(CH3)CONH(CH2CH=CH2) 082 F SOCH2CH3 083 F SO2CH3 084 F SO2NH2 085 F SO2N(CH3)2 086 F SO2N(CH2CH3)2 087 F SO2N (CH3) (CH2(4-CH3-C6H5)) 088 F SO2NHCH2CH2OCH3 089 F SCOOCH3 090 F SCON(CH3)2 Comp.No. R11 R13 In n = 689106, 137-146 091 F SCONHCH2CH=CH2 092 F SCOOCH2CH=CH2 093 F SCON(CH2CHs)COCF3 094 F CHO 095 F COCH3 096 F COOCH2CH3 097 F COOCH2C6Hs 098 F COCI 099 F COCH2CH2CI 100 F COOH 101 F COOCH3 102 F COOCH2CH3 103 F COOCH(CH3)2 104 F COOCH2CH=CH2 105 F COO(CH2)5CH3 106 F COOCH(CH3)CH=CH2 107 F COOCH2CH2OCH2CH3 108 F COOCH(CH3)CH2SCH3 109 F COOCH2(oxiranyl) 110 F COO(cylopentyl) 111 F COSCH3 112 F COSCH(CH3)2 113 F COSCH2C6H5 114 F CONH2 115 F CONH(CH2CH=CH2) 116 F CONHCH2C6H5 117 F CON(CH2CH=CH2)2 118 F CON(CH3)OCH3 119 F COOCH2CH2COOH Comp.No. R11 R13 In n = 68-106, 137-146 120 F COOCH(CH3)COOCH3 121 F COOCH(CH3)COOCH2C6H5 122 F COOCH(CH3)CH2COOCH2CH3 123 F COOCH(CH3)CH2CONHCH2CH3 124 F COOCH (OH3)OH2CON (OH3)2 125 F COOCH(CH3)CH2COSCH2CH3 126 F CooCH(CH3)CH2COOCH2CH=CH2 127 F COOC(CH3)2COCH3 128 F COOC(CH3)2COOH 129 F COOC(CH3)2COOCH3 130 F COOC(CH3)2COOCH2CH3 131 F COOC(CH3)2COOCH(CH3)2 132 F COOC(CH3)COO(CH2)4CH3 133 F COOC(CH3)2COOCH2C6H5 134 F COOC(CH3)2COOCH2(2-F-C6H5) 135 F COOC(CH3)2COOCH2CH=CH2 136 F COOC(CH3)2COOCH(CH3)CH=CH2 137 F COOC(CH3)2COOCH2C=CH 138 F COO(CH3)2COOCH2CH20CH2CH3 139 F COOC(CH3)2COSCH3 140 F COOC(CH3)2COSCH(CH3)2 141 F COOC(CH3)2COSCH2C6H5 142 F COOC(CH3)2CONH2 143 F COOC(CH3)2CONHCH2CH=CH2 144 F COOC(CH3)2CON(CH2CH3)2 145 F COOC(CH3)2CON(CH3)CH2CH2OCH3 146 F COSCH(CH3)COOH 147 F COSCH(CH3)COOCH3 148 F COSCH(CH3)CONHCH2CH=CH2 Comp.No. R11 R13 In n = 68-106, 137-146 149 F CON(CH3)CH2COOH 150 F CON(CH3)C(CH3)2COOCH2CH3 151 F CON(CH3)0CH2COOCH3 152 F CON(CH3)OH 153 F CH3 154 F CH2CH3 155 F CH(OH)CH3 156 F CH(OCH2CH=CH2)CH3 157 F CH2CI 158 F CH20H 159 F CH20COCH3 160 F CHClCH3 161 F CH2CH2CF3 162 F CH=CHCF3 163 F CH2CH=CH2 164 F CH=CHCH3 165 F C-CH 166 F C-CCH20H 167 F CH2CHCICOOH 168 F (R)-CH2CHCICOOH 169 F (S)-CH2CHCICOOH 170 F CH2CH(CH3)COOH 171 F CH2CH(CH3)COOCH2CH3 172 F CH(CI)CH2COOCH3 173 F CH(Cl)C(Cl)2COOH 174 F CH(Cl)CH(Cl)COOCH2CH3 175 F CH2CH(CH3)COOH 176 F CH2CH(CH3)COCH2CH=CH2 177 F CH2CH(CH3)CONH(CH2CH=CH2) Comp.No. R11 R13 In n=68-106, 137-146 178 F CH2CH(CH3)CON(CH3)2 179 F CH2CH(CH3)COSCH(CH3)2 180 F CH2CHClCOOC(CH3)3 181 F CH2CHCICOOCH3 182 F CH2CHCICOOCH2CH3 183 F CH2CHCICOOCH(CH3)2 184 F CH2CHCICOOCH2CH=CH2 185 F CH2CHCICOOCH2C6Hs 186 F CH2CHCICOSCH(CH3)2 187 F CH2CHCICOSCH2C6H5 188 F CH2CHCICONH2 189 F CH2CHClCONH(CH2CH=CH2) 190 F CH2CHClCON(CH2CH3)2 191 F CH2CHCICONH(CH2C6H5) 192 F CH2CHClCON(CH3)CH2C6H5 193 F CH=CHCOOH 194 F (E)-CH=CHCOOH 195 F (Z)-CH=CHCOOH 196 F CH=CHCOOCH3 197 F CH-CHCOOCH2C6H5 198 F CH=CHCOONH2 199 F CH=CHCONH(CH2CH=CH2) 200 F CH=C(CI)COOH 201 F CH=C(CI)CONH2 202 F CH=C(Cl)CONH(CH2CH3) 203 F CH=C(Cl)CON(CH2CH3)2 204 F CH=C(Cl)CONH(CH2C6H5) 205 F CH=C(CI)COSCH3 206 F CH=C(Cl)COSCH(CH3)2 Comp.No. R11 R13 In n=68-106, 137-146 207 F CH=C(CH3)COOH 208 F CH=C(CH3)CONH(CH2CH=CH2) 209 F CH=C(CH3)CON(CH3)2 210 F CH=C(CH3)COSCH2CH3 211 F CH=C(CN)COOH 212 F CH=C(CN)COOC(CH3)3 213 F CH=C(CN)CON(CH2CH=CH2)2 214 F CH=C(COOH)2 215 F CH=C(C6H5)COOH 216 F CH=CHCH20H 217 Ci F 218 Cl H 219 Cl Cl 220 CI NH2 221 Cl OH 222 Cl SH 223 Cl Br 224 Cl 225 Cl CN 226 Cl SO2Cl 227 Cl NH(CH3) 228 Cl N(CH2CH3)2 229 Cl NH(COCH3) 230 Cl NH(CH2CH=CH2) 231 Cl N(CH3)(CH2C=CH) 232 CI N(S02CH3)2 233 Cl NH(SO2CH2CH3) 234 Cl N(CH2CH=CH2)(SO2CH2CH3) 235 Cl N(CH2C=CH)(SO2CH(CH3)2) Comp.No. R11 R13 In n=68-106, 137-146 236 Cl N(CH2CF3)(CHO) 237 Cl NH(CH2C6H5) 238 CI OCH3 239 Cl OCH2CH3 240 CI OCH(CH3)2 241 Cl OCH(CH3)CH2CH2CH3 242 Cl OCH2CH=CH2 243 Cl OCH(CH3)CH=CH2 244 Cl OCH2C.CH 245 Cl OCH(CH3)C=CH 246 Cl OCH(cyclopentyl) 247 Cl OCH2(C6H5) 248 Cl OCH2(2-F-C6H5) 249 Cl OCH(CH3)(4-CH3-C6H5) 250 Cl OC6H5 251 CI 0(4-pyrimidyl) 252 Cl OCH2CH2CI 253 Cl OCH2CH=CHCI 254 Cl OCH2CH20H 255 CI OCH20CH3 256 Cl OCH2CH20CH2CH3 257 Cl OCH2CH2OCH2CH2OCH2CH3 258 Cl OCH(CH3)CH2OCH2CH=CH2 259 CI OCOCH3 260 CI OCOOCH3 261 Cl OCOCH2C6H5 262 Cl OCH2SCH3 263 Cl OCH2CH2SCH2CH3 264 Cl OCH2COOH Comp.No. R11 R13 In n=68-106, 137-146 285 Cl OCH (CH3)OOOH 266 Cl (R)-OCH(CH3)COOH 267 Cl (S)-OCH(CH3)COOH 268 Cl OCH2COOCH2CH3 269 Cl OCH(CH3)COOCH3 270 Cl OCH(CH3)COOCH2CH=CH2 271 Cl OCH(CH3)COOCH2(C6H5) 272 Cl OCH(CH3)CH2COOH 273 Cl OCH(CH3)CH2COOCH2CH3 274 Cl OCH2COSCH3 275 Cl OCH(CH3)COSCH2CH3 276 Cl OCH(CH3)COSCH(CH3)2 277 Cl OCH2CONH2 278 Cl OCH2CON(CH2CH3)2 279 Cl OCH(CH3)CON(CH3)2 280 Cl OCH(CH3)CONH(CH2CH=CH2) 281 Cl OCH(CH3)CON(CH3)(CH2COCH) 282 Cl OCH(CH3)CON(CH2C6H5)2 283 Cl OCH(CH3)CON(CH3)(C6H5) 284 Cl OCH2COOCH2CH2SCH3 285 Cl OCH(CH(CH3)2)COOH 286 Cl OCH(CH3)COOCH2CH2OCH2CH3 287 Cl OCH(C6H5)COOH 288 Cl (R)-OCH(C6H5)COOH 289 Cl (S)-OCH(C6H5)COOH 290 Cl OCH(C6H5)COOCH3 291 Cl OCH(C6H6)OOOCH(CH3)C-CH 292 Cl OCH(C6H5)COOCH2C6H5 293 Cl OCH(C6H5)COSCH(CH3)2 Comp.No. R11 R13 In n=68-106, 137-146 294 Cl OCH(C6H5)CONH2 295 Cl OCH(C6H5)CONH(CH2C=CH) 296 Cl OCH (05H5) CON (CH2CH=OH2)2 297 Cl OCH(C6H5)CON(CH3)CH2C6H5 298 Cl OCH(C6H5)CONH(CH2(2-F-C6H5)) 299 Cl OCH(C6H5)CONH(cyclopropyl) 300 CI OCH2CH2COOH 301 Cl OCH2CH2COOCH2CH3 302 Cl OCH(CH3)CH2COOH 303 Cl SCH3 304 CI SCH(CH3)2 305 Cl SCH2CH=CH2 306 Cl SCH2C6H5 307 Cl SCH2CH2OCH3 308 Cl SC6H5 309 Cl SCH2COOH 310 Cl SCH2COOCH2C6HS 311 Cl SCH(CH3)COOH 312 Cl SCH(CH3)COOCH2CH3 313 Cl SCH(CH3)COOCH2CH=CH2 314 Cl SCH (0H3)COSCH3 315 Cl SCH(CH3)CON(CH3)2 316 Cl SCH(CH3)CONH(CH2CH=CH2) 317 Cl SOCH2CH3 318 Cl SO2CH3 319 Cl S°2NH2 320 Cl SO2N(CH3)2 321 Cl SO2N(CH2CH3)2 322 Cl SO2N(CH3)(CH2(4-CH3-C6H5)) Comp.No. R11 R 13 In n = 68-106, 137-146 323 CI SO2NHCH2CH20CH3 324 Cl SCOOCH3 325 Cl SCON(CH3)2 326 Cl SCONHCH2CH=CH2 327 Cl SCOOCH2CH=CH2 328 Cl SCON(CH2CH3)COCF3 329 CI CHO 330 Cl COCH3 331 Cl COOCH2CH3 332 Cl COOCH2C6H5 333 Cl COCI 334 Cl COCH2CH2CI 335 CI COOH 336 Cl COOCH3 337 CI COOCH2CH3 338 Cl COOCH(CH3)2 339 Cl COOCH2CH=CH2 340 Cl COO(CH2)5CH3 341 CI COOCH(CH3)CH=CH2 342 Cl COOCH2(2-F-C6H5) 343 Cl COOC6H5 344 Cl COOCH2CH2OCH2CH3 345 Cl COOCH(CH3)CH2SCH3 346 Cl COO(oxetanyl) 347 Cl COOCH2(oxiranyl) 348 Cl COO(cylopentyl) 349 Cl COSCH3 350 Cl COSCH(CH3)2 351 Cl COSCH2C6H5 Comp.No. R11 R13 In n=68-106, 137-146 352 Cl CONH2 353 CI CONH(CH2CH=CH2) 354 CL CONHCH2C6H5 355 Cl CON(CH2CH=CH2)2 356 Cl CON(CH3)0CH3 357 Cl COOCH2CH2COOH 358 Cl COOCH(CH3)COOCH3 359 Cl COOCH(CH3)COOCH2C6H5 360 Cl COOCH(CH3)CH2COOCH2CH3 361 Cl (S)-COOCH(CH3)CH2COOCH2CH=CH2 362 Cl (R)-COOCH(CH3)CH2COOCH2CH=CH2 363 Cl COOCH(CH3)CH2CONHCH2CH3 364 Cl COOCH (0H3)CH2CON (OH3)2 365 Cl COOCH(CH3)CH2COSCH2CH3 366 Cl COOCH(CH3)CH2COOCH2CH=CH2 367 Cl COOC(CH3)2COCH3 368 Cl COOC(CH3)2COOH 369 Cl COOC(CH3)2COOCH3 370 Cl COOC(CH3)2COOCH2CH3 371 Cl COOC(CH3)2COOCH(CH3)2 372 Cl COOC(CH3)COO(CH2)4CH3 373 Cl COOC(CH3)2COOCH2C6H5 374 Cl COOC(CH3)2COOCH2(2-F-C6H5) 375 Cl COOC(CH3)2COOCH2CH=CH2 376 Cl COOC(CH3)2COOCH(CH3)CH=CH2 377 Cl COOC(CH3)2COOCH2C=CH 378 Cl COO(CH3)2COOCH2CH2OCH2CH3 379 Cl COOC(CH3)2COSCH3 380 Cl COOC(CH3)2COSCH(CH3)2 Comp.No. R11 R13 In n =68-106, 137-146 381 Cl COOC(CH3)2COSCH2C6H5 382 CI COOC(CH3)2CONH2 383 Cl COOC(CH3)2CONHCH2CH=CH2 384 Cl COOC(CH3)2CON(CH2CH3)2 385 Cl COOC(CH3)2CON(CH3)CH2CH2OCH3 386 Cl COSCH(CH3)COOH 387 Cl COSCH(CH3)COOCH3 388 Cl COSCH(CH3)CONHCH2CH=CH2 389 Cl CON(CH3)CH2COOH 390 Cl CON(CH3)C(CH3)2COOCH2CH3 391 Cl CON(CH3)OCH2COOCH3 392 Cl CON(CH3)OH 393 Cl CH3 394 Cl CH2CH3 395 Cl CH(OH)CH3 396 Cl CH(OCH2CH=CH2)CH3 397 Cl CH2CI 398 Cl CH2OH 399 CL CH2OCOCH3 400 Cl CHClCH3 401 Cl CH2CH2CF3 402 Cl CH=CHCF3 403 Cl CH2CH=CH2 404 Cl CH=CH(CH3) 405 Cl COCH 406 Cl C.CCH2OH 407 Cl CH2CHCICOOH 408 Cl (R)-CH2CHClCOOH 409 Cl (S)~CH2CHCICOOH Comp.No. R11 R13 In n=68-106, 137-146 410 Cl CH2CH(CH3)COOH 411 Cl CH2CH(CH3)COOCH2CH3 412 CI CH(CI)CH2COOCH3 413 Cl CH(Cl)C(Cl)2COOH 414 Cl CH(Cl)CH(Cl)COOCH2CH3 415 Cl CH2CH(CH3)COOH 416 Cl CH2CH(CH3)COCH2CH=CH2 417 Cl CH2CH(CH3)CoNH(CH2CH=CH2) 418 Cl CH2CH(CH3)CON(CH3)2 419 Cl CH2CH(CH3)COSCH(CH3)2 420 Cl CH2CHCICOOC(CH3)3 421 Cl CH2CHCICOOCH3 422 Cl CH2CHCICOOCH2CH3 423 Cl CH2CHCICOOCH(CH3)2 424 Cl CH2CHClCOOCH2CH=CH2 425 Cl CH2CHCICOOCH2C6H6 426 Cl CH2CHClCOSCH3 427 Cl CH2CHCICOSCH(CH3)2 428 CI CH2CHCICOSCH2C6H5 429 Cl CH2CHCICONH2 430 Cl CH2CHClCONH(CH2CH=CH2) 431 Cl CH2CHCICON(CH2CH3)2 432 Cl CH2CHClCONH(CH2C6H5) 433 Cl CH2CHClCON(CH3)CH2C6H5 434 Cl CH=CHCOOH 435 Ol (E)-CH=CHCOOH 436 Cl (Z)-CH=CHCOOH 437 Cl CH=CHCOOCH3 438 Cl CH=CHCOOCH2C6H5 Comp.No. R 11 R13 In n = 68-106, 137-146 439 Cl CH=CHCOONH2 440 Cl CH=CHCONH(CH2CH=CH2) 441 Cl CH=C(Cl)COOH 442 Cl CH=C(CI)CONH2 443 Cl CH=C(CI)CONH(CH2CH3) 444 Cl CH=C(Cl)CON(CH2CH3)2 445 Cl CH=C(CI)CONH(CH2C6H5) 446 Cl CH=C(CI)COSCH3 447 Cl CH=C(CI)COSCH(CH3) 448 Cl CH=C(CH3)COOH 449 Cl CH=C(CH3)CONH(CH2CH=CH2) 450 Cl CH=C(CH3)CON(CH3)2 451 Cl CH=C(CH3)COSCH2CH3 452 Cl CH=C(CN)COOH 453 CI CH=C(CN)COOC(CH3)3 454 Cl CH=C(CN)CON(CH2CH=CH2)2 455 Cl CH=C(COOH)2 456 Cl CH=C(C6Hs)COOH 457 Cl CH=CHCH20H 458 H F 459 H H 460 H Cl 461 H Br 462 H 463 H NH2 464 H OH 465 H SH 466 H SO2Cl 467 H CN Comp.No. R11 R13 In n=68-106, 137-146 468 H NH(CH2C6H5) 469 H N(CH2CH=CH2)2 470 H N(S020H3)2 471 H NH(SO2CH2CH3 472 H NH(COCH3) 473 H OCH3 474 H OCH2CH3 475 H OCH2CH=CH2 476 H OCH2C=CH 477 H OCH2C6H5 478 H OCH2CH2CI 479 H OCH2CH2OH 480 H OCH2OCH3 481 H OCH2CH2OCH2CH3 482 H OCH2CH2OCH2CH2OCH3 483 H OCOCH3 484 H OCOOCH3 485 H OCH2SCH3 486 H OCH2CH2SCH3 487 H OCH2COOH 488 H OCH2COOCH3 489 H OCH2COOCH2C6H5 490 H OCH2CONH(CH3) 491 H OCH(CH3)COOH 492 H OCH(CH3)COOCH2CH3 493 H OCH(CH3)COOCH2CH=CH2 494 H OCH(CH3)COOCH2C6H5 495 H OCH(CH3)CONH2 496 H OCH(CH3)CONH(CH2CH=CH2) Comp.No. R11 R13 In n = 68-106, 137-146 497 H OCH(CH3)CON(CH3)2 498 H OCH(CH3)COSCH(CH3)2 499 H OCH(C6H5)COOH 500 H OCH(C6H5)COOCH3 501 H OCH(C6H5)COOCH2CH=CH2 502 H OCH(C6H5)CONH2 503 H OCH(C6H5)CONH(CH2CH3) 504 H OCH(C6H5)CON(CH3)2 505 H OCH(C6H5)COSCH3 506 H OCH(C6H5)COSCH(CH3)2 507 H OCH(CH3)CH2COOH 508 H OCH(CH3)CH2COOCH2CH3 509 H SCH3 510 H SCH(CH3)2 511 H SCH2C6H5 512 H SCH(CH3)COOH 513 H SCH(CH3)COOCH2CH3 514 H SO2NH2 515 H SO2NH(CH2CH=CH2) 516 H S02N(CH3)2 517 H SCOCH3 518 H SCOOCH2CH3 519 H CHOCOCH3 520 H COOH 521 H COCI 522 H COOCH3 523 H COOCH(CH3)2 524 H COOCH2C6H5 525 H COSCH(CH3)2 Comp.No. R11 R13 In n = 68-106, 137-146 526 H CONH2 527 H CONHCH2C6H5 528 H CON(CH2CH=CH2)2 529 H CON(CH3)0CH3 530 H COOCH(CH3)CH2COOH 531 H COOCH(CH3)COOCH2CH3 532 H COOCH(CH3)CH2COOCH2CH=CH2 533 H COOCH(CH3)CH2COSCH2CH3 534 H COOCH(CH3)CH2CONH2 535 H COOCH(CH3)CH2CONH(CH2CH=CH2) 536 H COOCH(CH3)COOH 537 H COOC(CH3)2COOH 538 H COOC(CH3)2COOCH3 529 H COOC(CH3)2COOCH(CH3)2 540 H COOC(CH3)2COOCH2CH3 541 H COOC(CH3)2COOCH2CH=CH2 542 H COOC(CH3)2COOCH2CH20CH2CH3 543 H COOC(CH3)2CONH2 544 H COOC(CH3)2CON(CH3)2 545 H COOC(CH3)2CONH(CH2CH=CH2) 546 H COSCH(CH3)COOH 547 H CON(CH3)C(CH3)2COOH 548 H CH3 549 H CH2CH3 550 H CH(OH)CH3 551 H CH2CI 552 H CH20H 553 H CH20COCH3 554 H CH=CHCF3 Comp.No. R11 R13 In n=68-106, 137-146 555 H CH2CH2CF3 556 H CH2CHCH2 557 H CH2CHClCOOH 558 H CH2CHCICOOCH2CH3 559 H CH2CHCICOOCH2C8H5 560 H CH2CHCICOOCH2CH=CH2 561 H CH2CHCICOOC(CH3)3 562 H CH2CHClCOSCH(OH3)2 563 H CH2CHCICONH2 564 H CH2CHClCONH(CH2CH3) 565 H CH2CHCICON(CH3)2 566 H CH(CI)CH(CI)COOH 567 H CH2C(CH3)CICOOH 568 H CH2C(CH3)CICOOCH2CH3 569 H CH2C(CH3)ClCOSCH3 570 H CH2C(CH3)ClCONH(CH2CH=CH2) 571 H CH2C(CH3)ClCON(CH3) (CH2CH=CH2) 572 H CH=CHCOOH 573 H CH=C(CH3)COOH 574 H CH=C(CI)COOH 575 H CH=C(CN)COOH 576 H CH=C(CN)COOCH2CH=CH2 577 H CH=C(CI)COOCH2CH3 578 H CH=C(CH3)CONH(CH2CH=CH2) 579 H CH=C(CI)COSCH2CH3 580 H CH=C(CI)CON(CH3)2 581 CH3 F 582 CH3 H 583 CH3 CI Comp.No. R11 R13 In n = 68-106, 137-146 564 CH3 Br 585 CH3 586 CH3 NH2 587 CH3 OH 588 CH3 SH 589 CH3 SO2Cl 590 CH3 CN 591 CH3 NH(CH2C6Hs) 592 CH3 N(CH2CH=CH2)2 593 CH3 N(SO2CH3)2 594 CH3 NH(SO2CH2CH3 595 CH3 NH(COCH3) 596 CH3 OCH3 597 CH3 OCH2CH3 598 CH3 OCH2CH=CH2 599 CH3 OCH2C=CH 600 CH3 OCH2C6H5 601 CH3 OCH2CH2Cl 602 CH3 OCH2CH20H 603 CH3 OCH20CH3 604 CH3 OCH2CH2OCH2CH3 605 CH3 OCH2CH20CH2CH20CH3 606 CH3 OCOCH3 607 CH3 OCOOCH3 608 CH3 OCH2SCH3 609 CH3 OCH2CH2SCH3 610 CH3 OCH2COOH 611 CH3 OCH2COOCH3 612 CH3 OCH2COOCH2C6H5 Comp.No. R11 R13 In n=68-106, 137-146 613 CH3 OCH2CONH(CH3) 614 CH3 OCH(CH3)COOH 615 CH3 OCH(CH3)COOCH2CH3 616 CH3 OCH(CH3)COOCH2CH=CH2 617 CH3 OCH(CH3)COOCH2C6H5 618 CH3 OCH(CH3)CONH2 619 CH3 OCH (CH3)CON H (CH2CH =CH2) 620 CH3 OCH(CH3)CON(CH3)2 621 CH3 OCH(CH3)COSCH(CH3)2 622 CH3 OCH(C6H5)COOH 623 CH3 OCH(C6H5)COOCH3 624 CH3 OCH(C6H5)COOCH2CH=CH2 625 CH3 OCH(C6H6)CONH2 626 CH3 OCH(C6H5)CONH(CH2CH3) 627 CH3 OCH(C6H5)CON(CH3)2 628 CH3 OCH(C6H5)COSCH3 629 CH3 OCH(C6H5)COSCH(CH3)2 630 CH3 OCH(CH3)CH2COOH 631 CH3 OCH(CH3)CH2COOCH2CH3 632 CH3 SCH3 633 CH3 SCH(CH3)2 634 CH3 SCH2C6H5 635 CH3 SCH(CH3)COOH 636 CH3 SCH(CH3)COOCH2CH3 637 CH3 SO2NH2 638 CH3 SO2NH(CH2CH=CH2) 639 CH3 SO2N(CH3)2 640 CH3 SCOCH3 641 CH3 SCOOCH2CH3 Comp.No. R11 R13 In n=68-106, 137-146 642 CH3 CHOCOCH3 643 CH3 COOH 644 CH3 COCl 645 CH3 COOCH3 646 CH3 COOCH(CH3)2 647 CH3 COOCH2C6H5 648 CH3 COSCH(CH3)2 649 CH3 CONH2 650 CH3 CONHCH2C6H5 651 CH3 CON(CH2CH=CH2)2 652 CH3 CON(CH3)OCH3 653 CH3 COOCH(CH3)CH2COOH 654 CH3 COOCH(CH3)COOCH2CH3 655 CH3 COOCH(CH3)CH2COOCH2CH=CH2 656 CH3 COOCH(CH3)CH2COSCH2CH3 657 CH3 COOCH(CH3)CH2CONH2 658 CH3 COOCH(CH3)CH2CONH(CH2CH=CH2) 659 CH3 COOCH(CH3)COOH 660 CH3 COOC(CH3)2COOH 661 CH3 COOC(CH3)2COOCH3 662 CH3 COOC(CH3)2COOCH(CH3)2 663 CH3 COOC(CH3)2COOCH2CH3 664 CH3 COOC(CH3)2COOCH2CH=CH2 665 CH3 COOC(CH3)2COOCH2CH2OCH2CH3 666 CH3 COOC(CH3)2CONH2 667 CH3 COOC(CH3)2CON(CH3)2 668 CH3 COOC(CH3)2CONH(CH2CH=CH2) 669 CH3 COSCH(CH3)COOH 670 CH3 CON(CH3)C(CH3)2COOH Comp.No. R11 R13 In n=68-106, 137-146 671 CH3 CH3 672 CH3 CH2CH3 673 CH3 CH(OH)CH3 674 CH3 CH2CI 675 CH3 CH20H 676 CH3 CH20COCH3 677 CH3 CH=CHCF3 678 CH3 CH2CH2CF3 679 CH3 CH2CH=CH2 680 CH3 CH2CHCICOOH 681 CH3 CH2CHCICOOCH2CH3 682 CH3 CH2CHCICOOCH2C6H5 683 CH3 CH2CHCICOOCH2CH=CH2 684 CH3 CH2CHCICOOC(CH3)3 685 CH3 CH2CHClCOSCH(CH3)2 686 CH3 CH2CHCICONH2 687 CH3 CH2CHCICONH(CH2CH3) 688 CH3 CH2CHCICON(CH3)2 689 CH3 CH(CI)CH(CI)COOH 690 CH3 CH2C(CH3)CICOOH 691 CH3 CH2C(CH3)CICOOCH2CH3 692 CH3 CH2C(CH3)CICOSCH3 693 CH3 CH2C(CH3)CICONH(CH2CH=CH2) 694 CH3 CH2C(CH3)CICON(CH3)(CH2CH=CH2) 695 CH3 CH=CHCOOH 696 CH3 CH=C(CH3)COOH 697 CH3 CH=C(CI)COOH 698 CH3 CH=C(CN)COOCH2CH=CH2 699 CH3 CH=C(CN)COOH Comp.No. R11 R13 In n=68-106, 137-146 700 CH3 CH=C(CI)COOCH2CH3 701 CH3 CH=C(CH3)CONH(CH2CH=CH2) 702 CH3 CH=C(CI)COSCH2CH3 703 CH3 CH=C(CI)CON(CH3)2 Table 4: Compounds of the formulae I107-I136, I149-I156, II1-II13, 1111-1119, IV1, IV2, V1 and V2 Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 001 H CI H 002 H Cl CH3 003 H CI COOH 004 H Cl COOCH3 005 H CI COOCH2CH3 006 H CI COOCH2C6H5 007 H Cl OH 008 H Cl OCH3 009 H CI OCH2C6Hs 010 H Cl OCH2COOH 011 H Cl F 012 H Cl CI 013 H CI Br 014 H Cl NH2 015 H Cl NHCOCH3 016 H Cl SH 017 H CI SCH3 018 H Br H 019 H Br CH3 020 H Br COOH 021 H Br COOCH3 022 H Br COOCH2CH3 023 H Br COOCH2C6H5 024 H Br OH 025 H Br OCH3 026 H Br OCH2C6H5 027 H Br OCH2COOH 028 H Br F Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 029 H Br Cl 030 H Br Br 031 H Br NH2 032 H Br NHCOCH3 033 H Br SH 034 H Br SCH3 035 F CI H 036 F Cl CH3 037 F CI COOH 038 F Cl COOCH3 039 F Cl COOCH2CH3 040 F Cl COOCH2C6Hs 041 F CI OH 042 F Cl OCH3 043 F Cl OCH2C6H5 044 F Cl OCH2COOH 045 F CI F 046 F CI Cl 047 F CI Br 048 F CI NH2 049 F Cl NHCOCH3 050 F CI SH 051 F CI SCH3 052 Cl Cl H 053 CI CI CH3 054 CI Cl COOH 055 Cl Cl COOCH3 056 CI Cl COOCH2CH3 Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 057 Cl Cl COOCH2C6H5 058 Cl CI OH 059 Cl CI OCH3 060 CI CI OCH2C6H5 061 CI Cl OCH2COOH 062 Cl Cl F 063 Cl Cl Cl 064 CI Cl Br 065 Cl Cl NH2 066 Cl CI NHCOCH3 067 Cl Cl SH 068 CI Cl SCH3 069 F Br H 070 F Br CH3 071 F Br COOH 072 F Br COOCH3 073 F Br COOCH2CH3 074 F Br COOCH2C6H5 075 F Br OH 076 F Br OCH3 077 F Br OCH2C6H5 078 F Br OCH2COOH 079 F Br F 080 F Br Cl 081 F Br Br 082 F Br NH2 083 F Br NHCOCH3 084 F Br SH Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 085 F Br SCH3 086 F CH3 H 087 F CH3 CH3 088 F CH3 COOH 089 F CH3 COOCH3 090 F CH3 COOCH2CH3 091 F CH3 COOCH2C6H5 092 F CH3 OH 093 F CH3 OCH3 094 F CH3 OCH2C6H5 095 F CH3 OCH2COOH 096 F CH3 F 097 F CH3 CI 098 F CH3 Br 099 F CH3 NH2 100 F CH3 NHCOCH3 101 F CH3 SH 102 F CH3 SCH3 103 Cl CF3 H 104 CI CF3 CH3 105 Cl CF3 COOH 106 Cl CF3 COOCH3 107 Cl CF3 COOCH2CH3 108 Cl CF3 COOCH2C6H5 109 Cl CF3 OH 110 Cl CF3 OCH3 111 Cl CF3 OCH2C6H5 112 CI CF3 OCH2COOH Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 113 CI CF3 F 114 Cl CF3 Cl 115 Cl CF3 Br 116 CI CF3 NH2 117 Cl CF3 NHCOCH3 118 Cl CF3 SH 119 CI CF3 SCH3 120 Cl CHF2 H 121 CI OHF2 CH3 122 CI CHF2 COOH 123 Cl CHF2 COOCH3 124 CI CHF2 COOCH2CH3 125 CI CHF2 COOCH2C6H5 126 CI OHF2 OH 127 Cl OHF2 OCH3 128 Cl OHF2 OCH2C6H5 129 CI CHF2 OCH2COOH 130 Cl OHF2 F 131 CI CHF2 Cl 132 Cl CHF2 Br 133 Cl CHF2 NH2 134 Cl CHF2 NHCOCH3 135 Cl CHF2 SH 136 Cl CHF2 SCH3 137 Cl CH3 H 138 Cl CH3 CH3 139 Cl CH3 COOH 140 Cl CH3 COOCH3 Comp.No. R 11 R t2 R t3 I107-I136; I149- I156; II1-II13; III1-III9; IV1, 2; V1, V2 141 Cl CH3 COOCH2CH3 142 Cl CH3 COOCH2C6H5 143 Cl CH3 OH 144 Cl CH3 OCH3 145 CI CH3 OCH2C6H5 146 Cl CH3 OCH2COOH 147 Cl CH3 F 148 Cl CH3 Cl 149 Cl CH3 Br 150 Cl CH3 NH2 151 Cl CH3 NHCOCH3 152 Cl CH3 SH 153 Cl CH3 SCH3 154 Cl CHO H 155 CI CHO CH3 156 Cl CHO COOH 157 CI CHO COOCH3 158 CI CHO COOCH2CH3 159 CI CHO COOCH2C6H5 160 CI CHO OH 161 Cl CHO OCH3 162 Cl CHO OCH2C6H5 163 Cl CHO OCH2COOH 164 CI CHO F 165 Cl CHO Cl 166 CI CHO Br 167 Cl CHO NH2 168 Cl CHO NHCOCH3 Comp.No. R11 R12 R13 I107-I136; I149- I156; II1-II13; III1-III9; IV1, IV2; V1, V2 169 Cl CHO SH 170 CI CHO SCH3 171 F CHO H 172 F CHO CH3 173 F CHO COOH 174 F CHO COOCH3 175 F CHO COOCH2CH3 176 F CHO COOCH2C6H5 177 F CHO OH 178 F CHO OCH3 179 F CHO OCH2C6H5 180 F CHO OCH2COOH 181 F CHO F 182 F CHO CI 183 F CHO Br 184 F CHO NH2 185 F CHO NHCOCH3 186 F CHO SH 187 F CHO SCH3 Table 5: Compounds prepared, from the preceding Tables 1-4, with physico-chemical data. Comp.No. Physico-chemical data I1.002 Melting point 95-96°C 11.003 Melting point 63-67°C I1.005 Melting point 126-128°C 11.007 Melting point 76-77°C I1.009 Melting point 133-134°C I1.022 Melting point 149-150°C 11.023 Melting point 82-83°C I1.024 Melting point 80-81°C I1.026 Solid I1.028 Melting point 122-123°C 11.031 Melting point 71-75°C 1,.046 Melting point 78-79°C 1,.088 Melting point 63-64°C I1.113 Melting point 120-121°C I1.114 Melting point 114-115°C I1.115 Melting point 82-85°C I1.119 Solid I1.120 Melting point 83-84°C 1,.121 'H-NMR (CDCl3): 7.70 ppm (d, 1H); 6.73 ppm (t, 1H); 4.48 ppm (q, 2H); 3.89 ppm (s, 3H); 1.43 ppm (t, 3H); solid 1,.122 Resin 1,.132 Resin 1,.134 Melting point 108-110°C I1.154 Amorphous I1.157 Resin li.159 Melting point 79-81°C 1,.164 Melting point 81-82°C I1-168 Solid 1,.177 Melting point 94-95°C I1.190 Melting point 92-94°C Comp.No. Physico-chemical data 1 .243 Melting point 88-89°C 1,.393 Melting point 133-134°C I1.735 Melting point 81-84°C 1,.736 Melting point 74-76°C 11.737 Solid I1.738 Melting point 76-79°C I1.739 Resin I1.740 Melting point 75-77°C I1.741 Melting point 115-116°C 11.742 Solid I1.743 Solid 11.744 Solid I1.745 Melting point 79-80°C I1.746 Melting point 83-84°C I1.747 Melting point 138-139°C I1.748 Melting point 76-77°C I1.749 Melting point 147-149°C I1.750 Melting point 57-62°C 1,.751 Resin I1.752 Resin I1.753 Melting point 134-136°C I1.754 Resin I1.755 Melting point 42-44°C 11.756 Melting point 115-116°C I1.757 Melting point 57-59°C I1.758 Resin I1.759 Resin 1,.760 Resin I1.761 Melting point 83-84°C I1.764 Isomer A: resin; isomer B: melting point 89-91°C I1.805 Amorphous 11.806 Melting point 84-880C Comp.No. Physico-chemical data 1,.807 Melting point 84-86°C 11.808 Melting point 108-109°C 14.002 Melting point 76-78°C 14.022 Solid 14.028 Meting point 98-101°C 14.121 Melting point 82-83°C 14.243 Resin 14.484 Solid 14.485 Solid 14.498 Solid 14.566 Solid 14.570 Solid 14.729 Solid 14.733 Solid I6.002 Melting point 80-81°C I6.028 Melting point 108-110°C I6.121 Melting point 88-89°C 19.002 Melting point 130-132°C 19.121 Melting point 137-1400C I10.002 Melting point 144-146°C 118.002 Melting point 61-64°C I18.243 Oil 119.002 Melting point 112-114°C I19.243 Melting point 92-93°C I20.002 Melting point 145-147°C I20.243 Melting point 120-135°C I30.002 Oil 130.243 Melting point 49-53°C 131.243 Melting point 105-108°C 132.002 Melting point 154-157°C 132.243 Melting point 107-112°C 163.001 Solid Comp.No. Physico-chemical data I68.002 Melting point 115-117°C I68.003 Melting point 114-118°C 170.153 Melting point 85-89°C 171.002 Melting point 81-83°C 171.023 Melting point 108-110°C I73.002 Melting point 56-58°C I73.023 Melting point 100-102°C 175.002 Melting point 159-1610C 175.473 Solid 176.002 Solid 197.002 Melting point 174-1760C I103.002 Melting point 79-80°C I104.002 Meting point 111-116°C I105.002 Melting point 77-79°C I106.002 Melting point 96-97°C 1107.035 Melting point 86-88°C I108.035 Solid hoe.052 Melting point 148-152°C I109.035 Melting point 83-85°C I110.035 Melting point 161-163°C I110.052 Solid I115.035 Melting point 92-94°C 1128.035 Melting point 84-86°C I129.103 Resin 1l29.052 Meting point 104-105°C I130.035 Melting point 194-196°C 1131.035 Melting point 110-111°C I132.035 Melting point 72-73°C I133.035 Solid 1.34.035 Melting point 92-94°C I135.035 Melting point 77-78°C I136.035 Melting point 108-109°C Comp.No. Physico-chemical data I137.002 Melting point 80-82°C I138.002 Melting point 47-49°C I139.002 Melting point 118-122°C 1144.002 Melting point 132-133°C I145.002 Melting point 83-84°C I146.002 Melting point 95-96°C 1147.101 Melting point 153-154°C 115.035 Melting point 99-100°C II10.035 Melting point 201-204°C 1113.035 Melting point 117-118°C III1.035 TLC analysis (silica gel 60 F254; n-hexane/AcOEt/AcOH 20/20/1: Rf- value 0.59 111,.052 TLC analysis (silica gel 60 F254; n-hexane/AcOEt/AcOH 20/20/1: Rf- value 0.67 1114.001 TLC analysis (silica gel 60 F254; n-hexane/AcOEtlAcOH 40120/1: Rf- value 0.33 1114.103 TLC analysis (silica gel 60 F254; n-hexane/AcOEt/AcOH 20/20/1: Rf- value 0.47 Formulation examples for active substances of the formula I (% = per cent bv weight F1. Emulsion concentrates a) b) c) d) Active substance according to Tables 1-4 5% 10% 25% 50% Calcium dodecylbenzene- sulfonate 6% 8% 6% 8% Castor oil polyglycol ether (36 mol of EO) 4% - 4% 4% Octylphenol polyglycol ether (7-8 mol of EO) - 4% - 2% Cyclohexanone - - 10% 20% Aromatic hydrocarbon mixture C9'C12 85% 78% 55% 16% Emulsions of any desired concentration can be preprepared from such concentrates by dilution with water.

F2. Solutions a) b) c) d) Active substance according to Tables 1-4 5% 10% 50% 90% I -Methoxy-3- (3-methoxy- propoxy)propane - 20% 20% - Polyethylene glycol molecular weight 400 20% 10% - - N-Methyl-2-pyrrolidone - - 30% 10% Aromatic hydrocarbon mixture C9-C12 75% 60% - - The solutions are suitable for use in the form of tiny drops.

F3. Wettable powders a) b) c) d) Active substance according to Tables 1-4 5% 25% 50% 80% Sodium ligninsulfonate 4% - 3% - Sodium lauryl sulfate 2% 3% - 4% Sodium diisobutyl-naphthalene- sulfonate - 6% 5% 6% Octylphenol polyglycol ether (7-8 mol of EO) - 1 % 2% - Highly disperse silicic acid 1% 3% 5% 10% Kaolin 88% 62% 35% - The active substance is mixed thoroughly with the additives and the mixture is ground thoroughly in a suitable mill. Wettable powders which can be diluted with water to give suspensions of any desired concentration are obtained.

F4. Coated granules a) b) c) Active susbtance according to Tables 1-4 0.1% 5% 15% Highly disperse silicic acid 0.9% 2% 2% Inorganic carrier material 9.0% 93% 83% ( 0.1 - 1 mm), for example CaCO3 or SiO2 The active substance is dissolved in methylene chloride, the solution is sprayed onto the carrier and the solvent is then evaporated off in vacuo.

F5. Coated granules a) b) c) Active substance according to Tables 1-4 0.1% 5% 15% Polyethylene glycol molecular weight 200 1.0% 2% 3% Highly disperse silicic acid 0.9% 1% 2% Inorganic carrier material 98.0% 92% 80% ( 0.1 - 1 mm) for example CaCO3 or SiO2 The finely ground active substance is applied uniformly to the carrier material, which has been moistened with polyethylene glycol, in a mixer. Dust-free coated granules are obtained in this manner.

F6. Extruded granules a) b) c) d) Active substance according to Tables 1-4 0.1% 3% 5% 15% Sodium ligninsulfonate 1.5% 2% 3% 4% Carboxymethylcellulose 1.4% 2% 2% 2% Kaolin 97.0% 93% 90% 79% The active substance is mixed with the additives and the mixture is ground and moistened with water. This mixture is extruded and then dried in a stream of air.

F7. Dusts a) b) c) Active substance according to Tables 1-4 0.1% 1% 5% Talc 39.9% 49% 35% Kaolin 60.0% 50% 60% Ready-to-use dusts are obtained by mixing the active substance with the carriers and grinding the mixture on a suitable mill.

F8. Suspension concentrates a) b) c) d) Active substance according to Tables 1-4 3% 10% 25% 50% Ethylene glycol 5% 5% 5% 5% Nonylphenol polyglycol ether - 1% 2% - (15 mol of EO) Sodium ligninsulfonate 3% 3% 4% 5% Carboxymethylcellulose 1 % 1 % 1 % 1% 37% aqueous formaldehyde 0.2% 0.2% 0.2% 0.2% solution Silicone oil emulsion 0.8% 0.8% 0.8% 0.8% Water 87% 79% 62% 38% The finely ground active substance is mixed intimately with the additives. A suspension concentrate from which suspensions of any desired concentration can be prepared by dilution with water is thus obtained.

Biological examples Example B1: Herbicidal action before emeraence of the Dlants (pre-emeraence action) Monocotyledon and dicotyledon test plants are sown in standard soil in plastic pots.

Immediately after sowing, the test substances are sprayed on (500 l of water/ha) as an aqueous suspension or emulsion prepared from a 25% emulsion concentrate (Example F1, c)), corresponding to a dosage of 2000 g of AS/ha. The test plants are then grown under optimum conditions in a greenhouse. After a test period of 3 weeks, the test is evaluated with a 9-level scale of ratings (1 = complete damage, 9 = no action). Ratings of 1 to 4 (in particular 1 to 3) mean a good to very good herbicidal action.

Test plants: Setaria, Solanum The compounds according to the invention show a good herbicidal action.

Table B1 gives examples of the good herbicidal activity of the compounds of the formual Table B1: Pre-emergence action: Test plants: Setaria Solanum Dose [g of AS/ha] Active substance No.

I1.002 1 1 2000 I1.003 1 1 500 I1.005 2 1 2000 1,.007 1 1 2000 I1.009 1 1 2000 1,.022 1 1 2000 I1.023 1 1 2000 I1.024 1 1 2000 I1.026 1 1 2000 1,.028 1 1 2000 1,.031 1 1 2000 I1.046 1 1 2000 1,.088 1 1 2000 I1.113 1 1 2000 11.119 1 1 2000 I1.120 1 1 2000 I1.121 1 1 2000 1,.122 1 1 2000 1,.134 1 1 2000 I1.154 1 1 2000 I1.157 1 1 2000 I1.159 1 1 2000 I1.164 1 1 2000 1,.168 1 1 2000 1,.243 1 1 2000 I1.393 1 1 1 2000 I1.735 1 1 2 2000 1,.736 1 1 2000 1,.737 3 1 2000 1,.738 1 1 2000 1,.739 1 1 2000 I1.740 1 1 1 2000 I1.741 1 1 2000 I1.745 1 1 1 2000 I1.746 1 4 2000 I1.747 1 1 2000 I1.748 1 1 2000 I1.749 5 5 2 2000 I1.750 1 1 2000 14.002 1 1 2000 14.028 1 1 2000 14.121 1 1 2000 14.484 1 1 2000 14.485 1 1 2000 14.498 2 1 2000 14.566 2 1 2000 14.570 1 1 2000 I6.002 1 1 2000 I6.028 1 1 2000 I6.121 1 1 2000 19.002 1 1 2000 19.121 2 3 2000 I10.002 1 1 2000 120.002 1 1 2000 163.001 1 1 2000 168.002 1 1 2000 168.003 1 1 2000 171.002 1 1 2000 173.002 1 1 2000 1,5.002 2 1 2000 175.473 1 1 2000 175.002 1 1 2000 197.002 3 2 2000 1103.002 1 1 2000 I,o5.002 2 1 2000 I106.002 2 1 2000 113s.035 2 3 2000 1137.002 1 1 2000 The same results are obtained if the compounds of the formula I are formulated according to Examples F2 to F8.

Example B2: Post-emeraence herbicidal action Monocotyledon and dicotyledon test plants are grown in plastic pots with standard soil in a greenhouse and, in the 4- to 6-leaf stage, are sprayed with an aqueous suspension or emulsion of the test substances of the formula I, prepared from a 25% emulsion concentrate (Example F1, c)), corresponding to a dosage of 2000 g of AS/ha (500 1 of water/ha). The test plants are then grown further under optimum conditions in a greenhouse. After a test period of about 18 days, the test is evaluated with a 9-level scale of rating (1 = complete damage, 9 = no action). Ratings of 1 to 4 (in particular 1 to 3) mean a good to very good herbicidal action.

Test plants: Setaria, Sinapis, Solanum, Ipomoea The compounds of the formula I also show a potent herbicidal action in this test.

Table B2 gives examples of the good herbicidal activity of the compounds of the formula I.

Table B2: Post-emeraence action: Test plant: Setaria Sinapis Solanum Ipomoea Dose [g of AS/ha] Active substance No.

1,.002 1 1 1 1 2000 1,.003 2 1 1 1 500 1,.005 1 1 1 1 2000 1,.007 1 1 1 1 2000 I1.009 5 1 1 1 2000 I1.022 3 1 1 1 2000 1,.023 1 1 1 1 2000 1,.024 2 1 1 1 2000 1,.026 1 1 1 1 2000 1,.028 1 1 1 1 2000 1,.031 3 1 1 1 2000 I1.046 1 1 1 1 2000 I1.088 1 1 1 1 2000 li.113 1 1 1 1 2000 I1.119 1 1 1 1 2000 I1.120 1 1 1 1 2000 I1.121 1 1 1 1 2000 I1.122 1 1 1 1 2000 I1.134 1 1 1 1 2000 I1.154 1 1 1 1 2000 I1.157 1 1 1 1 2000 I1.159 2 1 1 1 2000 I1.164 1 1 1 1 2000 I1.168 2 1 1 1 2000 I1.243 1 1 1 1 2000 I1.393 1 1 1 1 2000 I1.735 3 2 1 1 2000 I1.736 1 1 1 1 2000 1,.737 2 1 1 1 2000 I1.738 1 1 1 1 2000 I1.739 1 1 1 1 2000 I1.740 1 1 1 1 2000 I1.741 1 1 1 1 2000 1,.742 1 1 1 1 2000 I1.743 1 1 1 1 2000 1,.744 1 1 1 1 2000 I1.745 4 1 1 1 2000 1,.746 3 2 1 1 2000 1,.747 1 1 1 1 2000 I1.748 3 1 1 1 2000 I1.749 5 2 1 1 2000 I1.750 1 1 1 1 2000 14.002 6 5 1 1 2000 14.028 2 1 1 1 2000 14.121 1 1 1 1 2000 14.484 4 6 1 1 2000 14.485 6 2 1 2 2000 14.570 3 4 1 1 2000 I6.002 6 3 1 1 2000 16.028 3 1 1 1 2000 16.121 1 1 1 1 2000 19.002 2 3 1 1 2000 19.121 3 3 1 1 2000 I10.002 5 6 1 1 2000 120.002 4 2 1 1 2000 I63.001 3 1 1 1 2000 I68.002 1 1 1 1 2000 I68.003 2 1 1 1 2000 I71.002 1 1 1 1 2000 I73.002 1 4 1 1 2000 175.002 6 3 2 1 2000 175.473 5 4 1 2 2000 197.002 5 2 1 1 2000 1103.002 6 5 1 3 2000 I105.002 6 5 1 1 2000 I106.002 3 2 1 1 2000 1137.002 4 1 1 1 2000 The same results are obtained if the compounds of the formula I are formulated according to Examples F2 to F8.