PROCESS FOR THE PREPARATION OF N'omega'-TRIFLUOROACETYLATED BASIC AMINO ACIDS

Title:

PROCESS FOR THE PREPARATION OF N'omega'-TRIFLUOROACETYLATED BASIC AMINO ACIDS

Document Type and Number:

WIPO Patent Application WO/1997/032841

Kind Code:

A1

Abstract:

A process for preparing an N'omega'-trifluoroacetylated basic amino acid from a basic amino acid and a trifluoroacetic acid ester, characterized by gradually adding a trifluoroacetic acid ester to an aqueous basic solution containing a basic amino acid in a concentration of about 5 to 40 % (w/v) based on the volume of the solvent charged and a basic pH regulator while keeping the aqueous solution at a pH of 10.6 to 11.4 and a temperature of 20 �C or below to conduct a reaction, making the formed N'omega'-trifluoroacetylated basic amino acid crystallize out of the resulting aqueous solution, and separating the amino acid therefrom.

Inventors:

UEDA YASUYOSHI
MANABE HAJIME
MITSUDA MASARU

Application Number:

PCT/JP1997/000690

Publication Date:

September 12, 1997

Filing Date:

March 06, 1997

Export Citation:

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Assignee:

KANEKA CORP (JP)

International Classes:

C07C231/02; C07C231/24; (IPC1-7): C07C233/47; C07C231/02; C07C231/24

Foreign References:

JPS62226952A

1987-10-05

Other References: