PROCESS FOR PRODUCING BENZO[c]PHENANTHRIDINE DERIVATIVE

WIPO Patent Application WO/2006/054494

A1

A compound represented by the following formula (1): [wherein R1 and R2 each independently represents hydroxy, provided that R1 and R2 may be bonded to each other to form methylenedioxy, etc.; X represents halogeno; and R3 represents a protective group] is subjected to a cyclization reaction with the aid of an organic silyl hydride and then aromatized with an oxidizing agent to produce a benzo[c]phenanthridine derivative represented by the following formula (2): [wherein R1, R2, and R3 have the same meanings as defined above].

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YAMAZAKI HIROKO (JP)
MASUDA AKIRA (JP)

PCT/JP2005/020733

May 26, 2006

November 11, 2005

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NIPPON KAYAKU KK (JP)
YAMAZAKI HIROKO (JP)
MASUDA AKIRA (JP)

C07D491/056; C07D221/18

JPH04173789A

1992-06-22

NAKANISHI T. ET AL: "Synthesis of NK109, an Anticancer Benzo[c]phenanthridine Alkaloid", JOURNAL OF ORGANIC CHEMISTRY, vol. 63, no. 13, 1998, pages 4235 - 4239, XP002995264
LESAGE M. ET AL: "Tris(trimethylsilyl)silane: A Catalyst for Radical Mediated Reduction Reactions", TETRAHEDRON LETTERS, vol. 30, no. 21, 1989, pages 2733 - 2734, XP002995265
GIESE B. ET AL: "Tris(trimethylsilyl)silane as Mediator in Organic Synthesis via Radicals", TETRAHEDRON LETTERS, vol. 30, no. 6, 1989, pages 681 - 684, XP002995266

Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)

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