Title:
PARKINSON'S DISEASE MODEL MOUSE, PROCESS FOR PRODUCING THE MOUSE, AND SCREENING METHOD AND EVALUATION METHOD FOR THERAPEUTIC AGENT FOR PARKINSON'S DISEASE EACH USING THE MOUSE
Document Type and Number:
WIPO Patent Application WO/2010/107090
Kind Code:
A1
Abstract:
Disclosed are: a Parkinson's disease model mouse which can develop the symptoms of Parkinson's disease reliably in the early stage; a process for producing the mouse; and a screening method and an evaluation method for a therapeutic agent for Parkinson's disease, each of which utilizes the mouse. The Parkinson's disease model mouse is characterized in that a gene encoding parkin is inactivated and IRP2 is expressed specifically in nerve cells.
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Inventors:
IWAI KAZUHIRO (JP)
HATTORI NOBUTAKA (JP)
SAKATA SHIN-ICHI (JP)
HATTORI NOBUTAKA (JP)
SAKATA SHIN-ICHI (JP)
Application Number:
PCT/JP2010/054691
Publication Date:
September 23, 2010
Filing Date:
March 18, 2010
Export Citation:
Assignee:
UNIV OSAKA (JP)
JUNTENDO EDUCATIONAL FOUNDATIO (JP)
IWAI KAZUHIRO (JP)
HATTORI NOBUTAKA (JP)
SAKATA SHIN-ICHI (JP)
JUNTENDO EDUCATIONAL FOUNDATIO (JP)
IWAI KAZUHIRO (JP)
HATTORI NOBUTAKA (JP)
SAKATA SHIN-ICHI (JP)
International Classes:
A01K67/027; C12N15/09; G01N33/15; G01N33/50
Other References:
WANG, H. ET AL.: "Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss", J. NEUROCHEM., vol. 107, no. 1, 7 August 2008 (2008-08-07), pages 171 - 185
SHIN'ICHI SAKATA ET AL.: "Neuron Tokuiteki IRP2 Transgenic Mouse wa Shinkei Hensei o Hikiokosu", BMB2007 KOEN YOSHISHU, 25 November 2007 (2007-11-25), pages 139
MENENDEZ, J. ET AL.: "Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein", HUM. MOL. GENET., vol. 15, no. 13, 12 May 2006 (2006-05-12), pages 2045 - 2058
"Dai 28 Kai Annual Meeting of the Molecular Biology Society of Japan Koen Yoshishu, 25 November 2005 (25.11.2005)", 25 November 2005, article SHIN'ICHI SAKATA ET AL.: "Tetsu Taisha Ijo to Shinkei Hensei Shikkan to no Inga Kankei Kaimei o Mokuteki to shita No Tokuiteki IRP2 Transgenic Mouse no Kaiseki", pages: 324
ITIER, J. ET AL.: "Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse", HUM. MOL. GENET., vol. 12, no. 18, 22 July 2003 (2003-07-22), pages 2277 - 2291
GOLDBERG, M. ET AL.: "Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons", J. BIOL. CHEM., vol. 278, no. 44, 20 August 2003 (2003-08-20), pages 43628 - 43635
SATO, S. ET AL.: "Decline of Striatal Dopamine Release in Parkin-Deficient Mice Shown by Ex Vivo Autoradiography", J. NEUROSCI. RES., vol. 84, no. 6, 29 August 2006 (2006-08-29), pages 1350 - 1357
SHIN'ICHI SAKATA ET AL.: "Ubiquitin System to Tetsu Taisha", BIO INDUSTRY, vol. 21, no. 4, 12 April 2004 (2004-04-12), pages 17 - 26
LAVAUTE, T. ET AL.: "Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice", NAT. GENET., vol. 27, no. 2, February 2001 (2001-02-01), pages 209 - 214
SHIN'ICHI SAKATA ET AL.: "Neuron Tokuiteki IRP2 Transgenic Mouse wa Shinkei Hensei o Hikiokosu", BMB2007 KOEN YOSHISHU, 25 November 2007 (2007-11-25), pages 139
MENENDEZ, J. ET AL.: "Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein", HUM. MOL. GENET., vol. 15, no. 13, 12 May 2006 (2006-05-12), pages 2045 - 2058
"Dai 28 Kai Annual Meeting of the Molecular Biology Society of Japan Koen Yoshishu, 25 November 2005 (25.11.2005)", 25 November 2005, article SHIN'ICHI SAKATA ET AL.: "Tetsu Taisha Ijo to Shinkei Hensei Shikkan to no Inga Kankei Kaimei o Mokuteki to shita No Tokuiteki IRP2 Transgenic Mouse no Kaiseki", pages: 324
ITIER, J. ET AL.: "Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse", HUM. MOL. GENET., vol. 12, no. 18, 22 July 2003 (2003-07-22), pages 2277 - 2291
GOLDBERG, M. ET AL.: "Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons", J. BIOL. CHEM., vol. 278, no. 44, 20 August 2003 (2003-08-20), pages 43628 - 43635
SATO, S. ET AL.: "Decline of Striatal Dopamine Release in Parkin-Deficient Mice Shown by Ex Vivo Autoradiography", J. NEUROSCI. RES., vol. 84, no. 6, 29 August 2006 (2006-08-29), pages 1350 - 1357
SHIN'ICHI SAKATA ET AL.: "Ubiquitin System to Tetsu Taisha", BIO INDUSTRY, vol. 21, no. 4, 12 April 2004 (2004-04-12), pages 17 - 26
LAVAUTE, T. ET AL.: "Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice", NAT. GENET., vol. 27, no. 2, February 2001 (2001-02-01), pages 209 - 214
Attorney, Agent or Firm:
KIYOHARA YOSHIHIRO (JP)
Yoshihiro Kiyohara (JP)
Yoshihiro Kiyohara (JP)
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