Title:
PARTICLE AND PHARMACEUTICAL COMPOSITION COMPRISING AN INSOLUBLE CAMPTOTHECIN COMPOUND WITH DOUBLE CORE-SHELL STRUCTURE AND METHOD FOR MANUFACTURING THE SAME
Document Type and Number:
WIPO Patent Application WO/2018/236190
Kind Code:
A1
Abstract:
The present invention relates to a drug delivery system having a double core-shell structure and, specifically, to a double nano-drug delivery system having an inner core-shell containing a poorly soluble camptothecin compound and a water-soluble camptothecin compound inside and an amphiphilic polymer shell, and to a manufacturing method therefor. The double core-shell structured particles manufactured by the present invention form very stable particles and show a mono-distribution of particles before and after freeze-drying. The particles of the present invention show excellent results compared with existing monolayer micelles in animal efficacy tests and pharmacokinetic tests, and do not use a surfactant causing hypersensitivity, and thus the use of the particles of the present invention can provide a pharmaceutical composition or a drug delivery system platform, which are safe for the human body.
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Inventors:
PARK YOUNG HWAN (KR)
LEE IL HYUN (KR)
LEE IL HYUN (KR)
Application Number:
PCT/KR2018/007114
Publication Date:
December 27, 2018
Filing Date:
June 22, 2018
Export Citation:
Assignee:
SNBIOSCIENCE INC (KR)
International Classes:
A61K9/107; A61K31/4745; A61K47/30
Domestic Patent References:
| WO2016009227A1 | 2016-01-21 | |||
| WO2006049447A1 | 2006-05-11 |
Foreign References:
| US20150265716A1 | 2015-09-24 | |||
| US20100203150A1 | 2010-08-12 | |||
| US20120100220A1 | 2012-04-26 | |||
| KR20170079354A | 2017-07-10 | |||
| CN102961332A | 2013-03-13 |
Other References:
STEWART, CLINTON F. ET AL.: "Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice", CANCER CHEMOTHER PHARMACOL, vol. 40, no. 3, 1997, pages 259 - 265, XP055565817
"Remington's Pharmaceutical Sciences", 1995
"Remington's Pharmaceutical Sciences", 1995
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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