Title:
PARTICULATE AGENTS
Document Type and Number:
WIPO Patent Application WO1992004916
Kind Code:
A3
Abstract:
A novel means of pharmaceutical delivery for therapy or prophylaxis or to assist surgical or diagnostic operations on the living body is provided by neuronal endocytosis and axonal transport following pharmaceutical administration into vascularized, peripherally innervated tissue, e.g. intramuscular injections of a nerve adhesion molecule in coupled particle comprising a physiologically active substance or a diagnostic marker.
Inventors:
FILLER AARON GERSHON (GB)
Application Number:
PCT/EP1991/001780
Publication Date:
August 20, 1992
Filing Date:
September 13, 1991
Export Citation:
Assignee:
ST GEORGE S ENTERPRISES LTD (GB)
International Classes:
A61K47/48; A61K49/18; (IPC1-7): A61K47/48; A61K49/00
Domestic Patent References:
| WO1990001295A1 | 1990-02-22 | |||
| WO1986001112A1 | 1986-02-27 | |||
| WO1988000060A1 | 1988-01-14 | |||
| WO1989009625A1 | 1989-10-19 |
Other References:
STN File Server, File Medline, accession no. 87239688, J.E. GALLAGHER et al.: "Sialic acid mediates the initial binding of positively charged inorganic particles to alveolar macrophage membranes", & AM. REV. RESPIR. DIS., 135(6), JUNE 1987, 1345-52, see the whole abstract
STN File Server, File Medline, accession no. 86085167, D. MENETREY: "Retrograde tracing of neural pathways with a protein-gold complex. I. Light microscopic detection after silver intensification", & HISTOCHEMISTRY, 83(5), 1985, 391-5, see the whole abstract
STN File Server, File Medline, accession no. 86085167, D. MENETREY: "Retrograde tracing of neural pathways with a protein-gold complex. I. Light microscopic detection after silver intensification", & HISTOCHEMISTRY, 83(5), 1985, 391-5, see the whole abstract
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