Title:
PEPTIDE ANTAGONISTS OF TGF-BETA FAMILY MEMBERS AND THERAPEUTIC USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003093293
Kind Code:
A3
Abstract:
This invention is drawn to methods of using peptide-based antagonists of TGF-beta to facilitate the healing of cutaneous wounds that includes burns, lacerations and scrapes. The administration of peptide TGF-beta antagonists to wounds results in reduced scarring, wound contraction and deposition of extracellular matrix components, and increased rates of re-epithelialiation during wound healing.
Inventors:
HUANG JUNG SAN (US)
Application Number:
PCT/US2003/011437
Publication Date:
April 07, 2005
Filing Date:
April 15, 2003
Export Citation:
Assignee:
HUANG JUNG SAN (US)
UNIV SAINT LOUIS (US)
UNIV SAINT LOUIS (US)
International Classes:
A61K38/07; C07K14/47; (IPC1-7): C07K7/06; A61K38/04; A61K38/07; A61K38/08; A61K38/10; A61K38/16; C07K7/08; C07K14/00; C07K14/495
Domestic Patent References:
| WO2000031135A1 | 2000-06-02 |
Foreign References:
| US5571714A | 1996-11-05 | |||
| US4423037A | 1983-12-27 |
Other References:
See also references of EP 1534737A4
Download PDF: