Title:
PEPTIDE HAVING ANGIOGENESIS INHIBITORY ACTIVITY AND COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2015/076621
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis, and more specifically, to a composition effective in the treatment and prevention of angiogenesis-related diseases, containing a peptide derived from telomerase. According to the present invention, a peptide having the sequence of the sequence number, or a peptide, which is a peptide having a sequence with a homology of 80% to said sequence or a fragment thereof, has remarkable effects on angiogenesis inhibition.
Inventors:
KIM SANG JAE (KR)
KIM BUM JOON (KR)
SEO DONG-WAN (KR)
KIM BUM JOON (KR)
SEO DONG-WAN (KR)
Application Number:
PCT/KR2014/011280
Publication Date:
May 28, 2015
Filing Date:
November 21, 2014
Export Citation:
Assignee:
KAEL GEMVAX CO LTD (KR)
KIM SANG JAE (KR)
KIM SANG JAE (KR)
International Classes:
A61K38/10; A61K38/17; A61P35/00
Foreign References:
| US20030027769A1 | 2003-02-06 | |||
| US20030143228A1 | 2003-07-31 | |||
| US20110135692A1 | 2011-06-09 | |||
| US20130129760A1 | 2013-05-23 | |||
| US20070190561A1 | 2007-08-16 |
Other References:
KIM ET AL.: "Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-la-VEGF signaling axis", BIOMATERIALS, vol. 35, 8 January 2014 (2014-01-08), pages 2924 - 2933, XP028829049
MORANO KA, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1113, 2007, pages 1 - 14
CALDERWOOD SK ET AL., TRENDS IN BIOCHEMICAL SCIENCES, vol. 31, 2006, pages 164 - 72
JAATTELA M, INTERNATIONAL JOURNAL OF CANCER JOURNAL INTERNATIONAL DU CANCER, vol. 60, 1995, pages 689 - 93
SEO JS ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 218, 1996, pages 582 - 7
VOLLOCH VZ ET AL., ONCOGENE, vol. 18, 1999, pages 3648 - 51
MURPHY ME, CARCINOGENESIS, vol. 34, 2013, pages 1181 - 8
ZHOU J ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 13506 - 13
BRUNS AF ET AL., PLOS ONE, vol. 7, 2012, pages E48539
SUN J ET AL., ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY, vol. 24, 2004, pages 2238 - 44
GONG W ET AL., ONCOLOGY REPORTS, 2013
EUSTACE BK ET AL., CELL CYCLE, vol. 3, 2004, pages 1098 - 100
EUSTACE BK ET AL., NATURE CELL BIOLOGY, vol. 6, 2004, pages 507 - 14
CALDERWOOD SK, TRENDS IN BIOCHEMICAL SCIENCES, vol. 31, 2006, pages 164 - 72
GARCIA-CARBONERO R ET AL., THE LANCET ONCOLOGY, vol. 14, 2013, pages E358 - 69
SUN J ET AL., ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 24, 2004, pages 2238 - 44
PFOSSER A ET AL., CARDIOVASCULAR RESEARCH, vol. 65, 2005, pages 728 - 36
FERRARINI M ET AL., JOURNAL INTERNATIONAL DU CANCER, vol. 51, 1992, pages 613 - 9
VANBUSKIRK A ET AL., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 170, 1989, pages 1799 - 809
YEH CH ET AL., LEUKEMIA RESEARCH, vol. 34, 2010, pages 605 - 9
KOCSIS J ET AL., CELL STRESS & CHAPERONES, vol. 15, 2010, pages 143 - 51
DEMPSEY NC ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 87, 2010, pages 467 - 76
GANJI PN ET AL., ANGIOGENESIS, vol. 16, 2013, pages 903 - 17
BOHONOWYCH JE ET AL., BMC CANCER, vol. 11, 2011, pages 520
EVANS CG ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 4585 - 602
POWERS MV ET AL., CELL CYCLE, vol. 9, 2010, pages 1542 - 50
UEHARA Y, CURRENT CANCER DRUG TARGETS, vol. 3, 2003, pages 325 - 30
DU R ET AL., CANCER CELL, vol. 13, 2008, pages 206 - 20
See also references of EP 3072519A4
MORANO KA, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1113, 2007, pages 1 - 14
CALDERWOOD SK ET AL., TRENDS IN BIOCHEMICAL SCIENCES, vol. 31, 2006, pages 164 - 72
JAATTELA M, INTERNATIONAL JOURNAL OF CANCER JOURNAL INTERNATIONAL DU CANCER, vol. 60, 1995, pages 689 - 93
SEO JS ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 218, 1996, pages 582 - 7
VOLLOCH VZ ET AL., ONCOGENE, vol. 18, 1999, pages 3648 - 51
MURPHY ME, CARCINOGENESIS, vol. 34, 2013, pages 1181 - 8
ZHOU J ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, 2004, pages 13506 - 13
BRUNS AF ET AL., PLOS ONE, vol. 7, 2012, pages E48539
SUN J ET AL., ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY, vol. 24, 2004, pages 2238 - 44
GONG W ET AL., ONCOLOGY REPORTS, 2013
EUSTACE BK ET AL., CELL CYCLE, vol. 3, 2004, pages 1098 - 100
EUSTACE BK ET AL., NATURE CELL BIOLOGY, vol. 6, 2004, pages 507 - 14
CALDERWOOD SK, TRENDS IN BIOCHEMICAL SCIENCES, vol. 31, 2006, pages 164 - 72
GARCIA-CARBONERO R ET AL., THE LANCET ONCOLOGY, vol. 14, 2013, pages E358 - 69
SUN J ET AL., ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 24, 2004, pages 2238 - 44
PFOSSER A ET AL., CARDIOVASCULAR RESEARCH, vol. 65, 2005, pages 728 - 36
FERRARINI M ET AL., JOURNAL INTERNATIONAL DU CANCER, vol. 51, 1992, pages 613 - 9
VANBUSKIRK A ET AL., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 170, 1989, pages 1799 - 809
YEH CH ET AL., LEUKEMIA RESEARCH, vol. 34, 2010, pages 605 - 9
KOCSIS J ET AL., CELL STRESS & CHAPERONES, vol. 15, 2010, pages 143 - 51
DEMPSEY NC ET AL., JOURNAL OF LEUKOCYTE BIOLOGY, vol. 87, 2010, pages 467 - 76
GANJI PN ET AL., ANGIOGENESIS, vol. 16, 2013, pages 903 - 17
BOHONOWYCH JE ET AL., BMC CANCER, vol. 11, 2011, pages 520
EVANS CG ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 4585 - 602
POWERS MV ET AL., CELL CYCLE, vol. 9, 2010, pages 1542 - 50
UEHARA Y, CURRENT CANCER DRUG TARGETS, vol. 3, 2003, pages 325 - 30
DU R ET AL., CANCER CELL, vol. 13, 2008, pages 206 - 20
See also references of EP 3072519A4
Attorney, Agent or Firm:
KIM, SUN-YOUNG (KR)
κΉμμ (KR)
κΉμμ (KR)
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