PEPTIDE FOR THE INDUCTION OF IMMUNE TOLERANCE AS TREATMENT FOR SYSTEMIC LUPUS ERYTHEMATOSUS

WIPO Patent Application WO/2012/116210

A3

The present invention relates to amino acid peptides comprising the sequence FIEWNKLRFRQGLEW and their use in methods for the diagnosis and/ or treatment of immune disorders such as systemic lupus erythematosus. Typically, at least one amino acid moiety in the peptide is a D-amino acid; and/ or the peptide is in a head-to-tail cyclic configuration; and/ or multiple copies of the peptide are coupled to a non-immunogenic polymeric matrix such as polylysine (as a multiple antigen peptide or MAP). Typically the peptide is capable of inhibiting the production of autoantibodies that bind double stranded DNA in a mammal having systemic lupus erythematosus (SLE).

JP5878912	Soluble hydrophobic core carrier composition for delivery of therapeutic agents, and method for producing and using the same.
WO/2009/121631	NANOPARTICLES FOR TARGETED DELIVERY OF ACTIVE AGENTS TO THE LUNG
WO/2007/125089	ANTIBODIES FOR THE DETECTION OF BACILLUS ANTHRACIS AND VACCINE AGAINST B. ANTHRACIS INFECTIONS

HAHN BEVRA H (US)
SKAGGS BRIAN J (US)
SINGH RAM RAJ (US)
EBLING FANNY M (US)
LA CAVA ANTONIO (US)
SINGH RAM PYARE (US)

PCT/US2012/026364

January 31, 2013

February 23, 2012

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UNIV CALIFORNIA (US)
HAHN BEVRA H (US)
SKAGGS BRIAN J (US)
SINGH RAM RAJ (US)
EBLING FANNY M (US)
LA CAVA ANTONIO (US)
SINGH RAM PYARE (US)

A61K47/48; A61K38/10; A61K38/18; A61K39/395; A61K47/42; A61K48/00; A61P17/00

US20100234302A1	2010-09-16
US7081242B1	2006-07-25
US7501132B2	2009-03-10
US20110028409A1	2011-02-03

WOOD, William J. (6701 Center Drive West Suite 105, Los Angeles California, US)

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