Title:
PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2014/111841
Kind Code:
A3
Abstract:
There is provided a peptide which is capable of binding to an MHC molecule in vitro and being presented to a T cell without antigen processing (i.e. an apitope) which peptide comprises all or a portion of the following proteolipid protein (PLP) peptides: PLP 36-61: HE ALTGTEKLIET YF SKN YQD YEYLI (SEQ ID NO. 1) PLP 179-206: TWTTCQSIAFPSKTSASIGSLCADARMY (SEQ ID NO. 2) PLP 207-234: GVLPWNAFPGKVCGSNLLSICKTAEFQM (SEQ ID NO. 3). There is also provided the use of such a peptide in a pharmaceutical composition and a method to treat and/or prevent a disease using such a peptide.
Inventors:
WRAITH DAVID (GB)
STREETER HEATHER (GB)
ORDONEZ LAURENCE (FR)
STREETER HEATHER (GB)
ORDONEZ LAURENCE (FR)
Application Number:
PCT/IB2014/058234
Publication Date:
October 30, 2014
Filing Date:
January 13, 2014
Export Citation:
Assignee:
APITOPE INT NV (BE)
MERCK SERONO SA (CH)
MERCK SERONO SA (CH)
International Classes:
C07K14/47
Domestic Patent References:
| WO2008055059A2 | 2008-05-08 | |||
| WO2012041867A2 | 2012-04-05 |
Attorney, Agent or Firm:
HOLLIDAY, Louise (120 Holborn, London EC1N 2DY, GB)
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