Title:
PEPTIDES HAVING CYTOTOXICITY INHIBITORY ACTIVITY AND METHOD OF SCREENING THESE PEPTIDES HAVING CYTOTOXICITY INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2002/092810
Kind Code:
A1
Abstract:
Peptide(s) having a lower cytotoxicity than selenocysteine, showing a cytotoxicity inhibitory activity and containing at least one selenocysteine. These peptide(s) have preferably the amino acid sequence corresponding to the amino acids at from the C-terminal 260-position to the 362-position of selenoprotein P or an amino acid sequence derived therefrom by deletion, substitution or addition of one to several amino acids, or contain an amino acid sequence having any of the above-described amino acid sequences or a part thereof.
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Inventors:
HIRASHIMA MASAKI (JP)
NARUSE TAKESHI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
GOTO TAKESHI (JP)
AKIYAMA KATSUHIKO (JP)
HATTORI WATARU (JP)
NARUSE TAKESHI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
GOTO TAKESHI (JP)
AKIYAMA KATSUHIKO (JP)
HATTORI WATARU (JP)
Application Number:
PCT/JP2002/004557
Publication Date:
November 21, 2002
Filing Date:
May 10, 2002
Export Citation:
Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
HISAMITSU PHARMACEUTICAL CO (JP)
HIRASHIMA MASAKI (JP)
NARUSE TAKESHI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
GOTO TAKESHI (JP)
AKIYAMA KATSUHIKO (JP)
HATTORI WATARU (JP)
HISAMITSU PHARMACEUTICAL CO (JP)
HIRASHIMA MASAKI (JP)
NARUSE TAKESHI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
GOTO TAKESHI (JP)
AKIYAMA KATSUHIKO (JP)
HATTORI WATARU (JP)
International Classes:
C07K14/47; G01N33/50; (IPC1-7): C12N15/09; C07K14/47; C12Q1/02
Domestic Patent References:
| WO2000031131A1 | 2000-06-02 |
Other References:
SIDDIQUI RAFET A. ET AL.: "Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1499, no. 3, January 2001 (2001-01-01), pages 265 - 275, XP004278237
TATSUYA MORIMOTO ET AL: "Fuhowa shibosan kasankabutsu oyobi lin-shishitsu kasankabutsu no yoru baiyo hakkekyu saibo U037 no saiboshi yudo", JOURNAL OF LIPID NUTRITION, vol. 9, no. 2, 2000, pages 119, XP002976043
KIM Y.H. ET AL: "Inhibition of c-Jun expression induces antioxidant enzymes under serum deprivation", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 374, no. 2, 2000, pages 339 - 346, XP002974596
TATSUYA MORIMOTO ET AL: "Fuhowa shibosan kasankabutsu oyobi lin-shishitsu kasankabutsu no yoru baiyo hakkekyu saibo U037 no saiboshi yudo", JOURNAL OF LIPID NUTRITION, vol. 9, no. 2, 2000, pages 119, XP002976043
KIM Y.H. ET AL: "Inhibition of c-Jun expression induces antioxidant enzymes under serum deprivation", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 374, no. 2, 2000, pages 339 - 346, XP002974596
Attorney, Agent or Firm:
Aoyama, Tamotsu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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