Title:
PEPTIDES OF IRF-1
Document Type and Number:
WIPO Patent Application WO2004089975
Kind Code:
A3
Abstract:
The present invention relates to peptides which serve to activate the tumour suppressor protein p53 by enhancing p300 binding of p53. The present invention also allows the screening of molecules which effect binding of IRF-1 to p300. Molecules so identified may be used as potential tumour suppressor agents or alternatively immune-suppression or anti-inflammatory agents. The present invention also relates to the treatment of tumours using peptides of IRF-1.
Inventors:
BALL KATHRYN LINDSAY (GB)
DORNAN DAVID (US)
DORNAN DAVID (US)
Application Number:
PCT/GB2004/001580
Publication Date:
May 26, 2005
Filing Date:
April 13, 2004
Export Citation:
Assignee:
UNIV DUNDEE (GB)
BALL KATHRYN LINDSAY (GB)
DORNAN DAVID (US)
BALL KATHRYN LINDSAY (GB)
DORNAN DAVID (US)
International Classes:
C07K14/47; G01N33/68; (IPC1-7): C07K14/47; G01N33/68
Foreign References:
| EP0571743A1 | 1993-12-01 | |||
| EP1273667A1 | 2003-01-08 |
Other References:
DATABASE ENTREZ PROTEIN NCBI; 30 December 1997 (1997-12-30), CONOLLY ET AL: "IRF 1 (Homo Sapiens)", XP002302521, retrieved from ENTREZ PROTEIN NCBI Database accession no. AAB93488
MERIKA MENIE ET AL: "Recruitment of CBP/p300 by IFNbeta enhanceosome is required for synergistic activation of transcription", MOLECULAR CELL, vol. 1, no. 2, January 1998 (1998-01-01), pages 277 - 287, XP002302518, ISSN: 1097-2765
TANAKA NOBUYUKI ET AL: "Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage", NATURE (LONDON), vol. 382, no. 6594, 1996, pages 816 - 818, XP002302519, ISSN: 0028-0836
BARLEV NICKOLAI A ET AL: "Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases", MOLECULAR CELL, vol. 8, no. 6, December 2001 (2001-12-01), pages 1243 - 1254, XP002302520, ISSN: 1097-2765
MERIKA MENIE ET AL: "Recruitment of CBP/p300 by IFNbeta enhanceosome is required for synergistic activation of transcription", MOLECULAR CELL, vol. 1, no. 2, January 1998 (1998-01-01), pages 277 - 287, XP002302518, ISSN: 1097-2765
TANAKA NOBUYUKI ET AL: "Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage", NATURE (LONDON), vol. 382, no. 6594, 1996, pages 816 - 818, XP002302519, ISSN: 0028-0836
BARLEV NICKOLAI A ET AL: "Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases", MOLECULAR CELL, vol. 8, no. 6, December 2001 (2001-12-01), pages 1243 - 1254, XP002302520, ISSN: 1097-2765
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