Title:
PEPTIDES THAT BIND TO EPITHELIAL CELL ADHESION MOLECULE
Document Type and Number:
WIPO Patent Application WO/2014/042209
Kind Code:
A1
Abstract:
[Problem] To provide novel peptides having a high binding capacity to the epithelial cell adhesion molecule (EpCAM), said peptides being easy to produce by chemical synthesis or a genetic engineering method. [Solution] By improving phage library screening methods, the present invention has led to success in screening for peptides having a higher binding capacity than peptides of the prior art. Furthermore, using previously-disclosed peptides having EpCAM binding capacity as lead compounds, a diverse group of derivates thereof was produced, and peptides that bind strongly to EpCAM were selected from said group. The peptides that were obtained exhibit an EpCAM binding capacity that is at least ten-fold that of peptides of the prior art, and are effective in detecting and diagnosing cancer cells.
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Inventors:
SHIBA KIYOTAKA (JP)
KOKUBUN KATSUTOSHI (JP)
SUGA KANAKO (JP)
KOKUBUN KATSUTOSHI (JP)
SUGA KANAKO (JP)
Application Number:
PCT/JP2013/074655
Publication Date:
March 20, 2014
Filing Date:
September 12, 2013
Export Citation:
Assignee:
JAPAN FOUND CANCER (JP)
International Classes:
C07K7/08; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N15/09; G01N33/53; G01N33/574
Foreign References:
| JP2011193728A | 2011-10-06 |
Other References:
JAPANESE FOUNDATION FOR CANCER RESEARCH: "Bunshi Imaging Kiki Kenkyu Kaihatsu Project/Shinki Akusei Shuyo Bunshi Probe no Kiban Gijutsu Kaihatsu/Bunshi Probe Yoso Gijutsu no Kaihatsu Akusei Shuyo Tokuiteki Jinko Peptide Aptamer no 'Sono Ba' Soshutsu Oyobi Nano Zairyo o Mochiita Bunshi Probe-ka Gijutsu no Kaihatsu", NEW ENERGY AND INDUSTRIAL TECHNOLOGY DEVELOPMENT ORGANIZATION (NEDO) HEISEI 20 TO 21 NENDO SEIKA HOKOKUSHO, 3 May 2011 (2011-05-03), pages 1 - 21
IWASAKI K. ET AL.: "Carcinomas Cell Imaging by Using EpCAM-binding Peptides Selected from the Cyclic Non-standard Peptide Library.", PEPTIDE SCIENCE 2010: PROCEEDINGS OF THE FIFTH INTERNATIONAL PEPTIDE SYMPOSIUM, March 2011 (2011-03-01), pages 114
SEIGNEURIC R. ET AL.: "From Nanotechnology to Nanomedicine: Applications to Cancer Research.", CURRENT MOLECULAR MEDICINE, vol. 10, 2010, pages 640 - 652
IWASAKI K. ET AL.: "Carcinomas Cell Imaging by Using EpCAM-binding Peptides Selected from the Cyclic Non-standard Peptide Library.", PEPTIDE SCIENCE 2010: PROCEEDINGS OF THE FIFTH INTERNATIONAL PEPTIDE SYMPOSIUM, March 2011 (2011-03-01), pages 114
SEIGNEURIC R. ET AL.: "From Nanotechnology to Nanomedicine: Applications to Cancer Research.", CURRENT MOLECULAR MEDICINE, vol. 10, 2010, pages 640 - 652
Attorney, Agent or Firm:
SATO & ASSOCIATES (JP)
Patent business corporation creation international patent firm (JP)
Patent business corporation creation international patent firm (JP)
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