Title:
PERINAPHTHENONE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011668
Kind Code:
A1
Abstract:
Disclosed in the present invention are a perinaphthenone compound and the use thereof. The compound can bind to E3 ubiquitin ligase tripartite motif 25 (TRIM25), thereby facilitating the recognition of TRIM25 to a pathogen and inducing proteasome-dependent ubiquitination degradation of the pathogen protein. The compound is expected to be used as a ligand for TRIM25 and have a broad application, for example, for preparing a PROTAC molecule. Therefore, the compound has good research and development value and application prospects.
Inventors:
YU LIYAN (CN)
CEN SHAN (CN)
ZHAO JIANYUAN (CN)
PANG XU (CN)
ZHANG TAO (CN)
LIU WANCANG (CN)
ZHANG TAO (CN)
CEN SHAN (CN)
ZHAO JIANYUAN (CN)
PANG XU (CN)
ZHANG TAO (CN)
LIU WANCANG (CN)
ZHANG TAO (CN)
Application Number:
PCT/CN2022/117379
Publication Date:
February 09, 2023
Filing Date:
September 06, 2022
Export Citation:
Assignee:
INST MED BIOTECHNOLOGY CAMS (CN)
International Classes:
C07C50/38; A61P31/12; A61P31/14; A61P31/20; A61P31/22; A61P35/00; C07C49/743; C07C50/34; C07D309/22; C07D317/26; C12P15/00; C12R1/66
Foreign References:
| CN113651683A | 2021-11-16 | |||
| CN108420815A | 2018-08-21 | |||
| CN106085868A | 2016-11-09 |
Other References:
GOMBODORJ SURENMANDAKH; YANG MING-HUA; SHANG ZHI-CHUN; LIU RUI-HUAN; LI TIAN-XIAO; YIN GUO-PING; KONG LING-YI: "New phenalenone derivatives from Pinellia ternata tubers derived Aspergillus sp.", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 120, 31 May 2017 (2017-05-31), IT , pages 72 - 78, XP085133517, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2017.05.014
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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