PERSULFATED CHONDROITIN SULFATES, PROCESS FOR PRODUCING THE SAME, AND ANTICOAGULANTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Title:

PERSULFATED CHONDROITIN SULFATES, PROCESS FOR PRODUCING THE SAME, AND ANTICOAGULANTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/1999/028351

Kind Code:

A1

Abstract:

Novel compounds different from heparin and having a high anticoagulant activity. These compounds are persulfated chondroitin sulfates having at least 3.5, on average, O-sulfate groups per disaccharide repeating unit or pharmacologically acceptable salts thereof. These compounds can be produced by reacting a chondroitin sulfate salt with sulfur trioxide in an aprotic solvent at 30 to 50 °C by regulating the molar ratio of the free hydroxyl groups in the chondroitin sulfate salt to the sulfur trioxide of 1:10 to 1:20.

Inventors:

IMANARI TOSHIO (JP)
TOIDA TOSHIHIKO (JP)
LINHARDT ROBERT J (US)

Application Number:

PCT/JP1998/000023

Publication Date:

June 10, 1999

Filing Date:

January 08, 1998

Export Citation:

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Assignee:

SHIN NIPPON YAKUGYO CO LTD (JP)
IMANARI TOSHIO (JP)
TOIDA TOSHIHIKO (JP)
LINHARDT ROBERT J (US)

International Classes:

C08B37/08; A61K31/715; A61P7/02; (IPC1-7): C08B37/08; A61K31/715

Foreign References:

JPH08301771A	1996-11-19
JPS6147701A	1986-03-08

Attorney, Agent or Firm:

Tanigawa, Hidejiro (6th floor Iwata Building, 5-12, Iidabashi 4-chom, Chiyoda-ku Tokyo 102, JP)

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