Title:
PH-SENSITIVE CATIONIC LIPID AND LIPID NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2024/018762
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing, without using relatively expensive starting materials, a more conveniently synthesizable pH-sensitive cationic lipid, and providing a lipid nanoparticle that contains this pH-sensitive cationic lipid. The present invention is a pH-sensitive cationic lipid represented by general formula (I) [R1 is a C1-22 hydrocarbon group; the three R1's in each molecule may be the same group as each other or may be groups that differ from each other; Z1 is a C1-6 alkylene group or a single bond; X is -N(R2)(R3) or is a 5- to 7-membered nonaromatic heterocyclic group (with the proviso that this group is bonded to Z1 by a carbon atom); and R2 and R3 are each independently a hydrogen atom or a C1-4 hydrocarbon group, but R2 and R3 may be bonded to each other with the formation of a 5- to 7-membered nonaromatic heterocycle].
Inventors:
SATO YUSUKE (JP)
HARASHIMA HIDEYOSHI (JP)
SUZUKI YUICHI (JP)
HARASHIMA HIDEYOSHI (JP)
SUZUKI YUICHI (JP)
Application Number:
PCT/JP2023/020385
Publication Date:
January 25, 2024
Filing Date:
May 31, 2023
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07C237/08; A61K9/51; A61K31/7088; A61K31/7105; A61K47/10; A61K47/18; A61K47/28; A61K47/34; A61K48/00; C07C231/02; C12N15/88
Domestic Patent References:
| WO2018062413A1 | 2018-04-05 | |||
| WO2022060871A1 | 2022-03-24 | |||
| WO2020257716A1 | 2020-12-24 |
Foreign References:
| JPH09501655A | 1997-02-18 | |||
| JPH10509862A | 1998-09-29 | |||
| JPH10501822A | 1998-02-17 |
Other References:
DURAND GRÉGORY, POEGGELER BURKHARD, BÖKER JUTTA, RAYNAL SIMON, POLIDORI ANGE, PAPPOLLA MIGUEL A., HARDELAND RÜDIGER, PUCCI BERNARD: "Fine-Tuning the Amphiphilicity: A Crucial Parameter in the Design of Potent α-Phenyl- N - tert -butylnitrone Analogues", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, no. 17, 1 August 2007 (2007-08-01), US , pages 3976 - 3979, XP093130690, ISSN: 0022-2623, DOI: 10.1021/jm0706968
Attorney, Agent or Firm:
TANAKA, Shinichiro et al. (JP)
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