Title:
NEUTRAL LIPID AND LIPID NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2024/018761
Kind Code:
A1
Abstract:
The present invention provides: a neutral lipid capable of suppressing the phase transition of endosomal membranes caused by phosphatidylcholine from being inhibited; and a lipid nanoparticle containing said neutral lipid. The present invention pertains to an ionic neutral lipid comprising a compound represented by general formula (I). [In formula (I), R1 is a C1-22 hydrocarbon group; three R1's in one molecule may be the same group or different groups; a1 and a2 are each independently an integer of 0 to 4; b1 and b2 are 0 or 1, satisfying b1+b2=1; R2 and R3 are each independently a hydrogen atom or a C1-3 alkyl group; and R4 is an anionic group.]
Inventors:
SATO YUSUKE (JP)
HARASHIMA HIDEYOSHI (JP)
SUZUKI YUICHI (JP)
HARASHIMA HIDEYOSHI (JP)
SUZUKI YUICHI (JP)
Application Number:
PCT/JP2023/020375
Publication Date:
January 25, 2024
Filing Date:
May 31, 2023
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07C237/08; A61K9/14; A61K31/7088; A61K31/7105; A61K31/711; A61K47/18; A61K48/00; C11B11/00
Domestic Patent References:
| WO2006002873A2 | 2006-01-12 | |||
| WO2018230710A1 | 2018-12-20 | |||
| WO2015178343A1 | 2015-11-26 | |||
| WO2019027055A1 | 2019-02-07 | |||
| WO2021226468A1 | 2021-11-11 |
Other References:
FRANCIS C. L., YANG Q., HART N. K., WIDMER F., MANTHEY M. K., HE-WILLIAMS H. M.: "Total Synthesis of Methotrexate-γ-TRIS-Fatty Acid Conjugates", AUSTRALIAN JOURNAL OF CHEMISTRY, C S I R O PUBLISHING, AU, vol. 55, no. 10, 1 January 2002 (2002-01-01), AU , pages 635 - 645, XP093131699, ISSN: 0004-9425, DOI: 10.1071/CH02125
Attorney, Agent or Firm:
TANAKA, Shinichiro et al. (JP)
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