Title:
PH-SENSITIVE LINKERS FOR DELIVERING A THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2017/012568
Kind Code:
A1
Abstract:
A pH-sensitive linker having the following Formula (I). Wherein X is (II); P is –C (O) NH- or –C (O) O-; Q is –R (CH2CH2O) m-, R (–C (O) NH-) z or –R [-C (O) CH2CH2-C (O) NH- (CH2CH2O) m] Y; R is a bond, -C1-12alkyl or C1-10alkoxy; m is 1 to 12; z is 1 to 4; and Y is 1 to 12. The linker can simultaneously bind metallic nanoparticles and one or more agents with various molecular size.
Inventors:
LIAO YU-JUNG (CN)
HUANG WEI-JAN (CN)
CHEN CHIA-NAN (CN)
LIN HUAN-YU (CN)
LIN CHING-YI (CN)
TSAI MENG-JU (CN)
HSU WAN-YI (CN)
CHI LI-LING (CN)
CHAO YE-SU (CN)
WU YI-HONG (CN)
HUANG WEI-JAN (CN)
CHEN CHIA-NAN (CN)
LIN HUAN-YU (CN)
LIN CHING-YI (CN)
TSAI MENG-JU (CN)
HSU WAN-YI (CN)
CHI LI-LING (CN)
CHAO YE-SU (CN)
WU YI-HONG (CN)
Application Number:
PCT/CN2016/090893
Publication Date:
January 26, 2017
Filing Date:
July 21, 2016
Export Citation:
Assignee:
GNT BIOTECH & MEDICALS CORP (CN)
International Classes:
A61K33/24; A61K33/242; A61K33/243; C07C243/26
Domestic Patent References:
| WO2013139942A1 | 2013-09-26 |
Foreign References:
| US20130138032A1 | 2013-05-30 | |||
| US20130331764A9 | 2013-12-12 |
Other References:
TIAN-MENG SUN ET AL.: "Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds", BIOMATERIALS, vol. 35, no. 2, 18 October 2013 (2013-10-18), XP028760825, ISSN: 1878-5905
TIAN-MENG SUN ET AL.: "Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds", BIOMATERIALS, vol. 35, no. 2, 18 October 2013 (2013-10-18), pages 836 - 845, XP028760825, ISSN: 1878-5905
FENG WANG ET AL.: "Doxorubicin-Tethered Responsive Gold Nanopaiticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells", ACS NANO, vol. 5, no. 5, 24 May 2011 (2011-05-24), pages 3679 - 3692, XP055347447, ISSN: 1936-0851
FENG WANG ET AL.: "Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells", ACS NANO, vol. 5, no. 5, 24 May 2011 (2011-05-24), pages 3679 - 3692, XP055347448, ISSN: 1936-0851
STEVEN M. ANSELL ET AL.: "3-(2-Pyridyldithio)propionic Acid Hydrazide as a Cross-Linker in the Formation of Liposome-Antibody Conjugates", BIOCONJUGATE CHEM., vol. 7, no. 4, 25 July 1996 (1996-07-25), pages 490 - 496, XP000637466, ISSN: 1043-1802
HYUN JIN LEE ET AL.: "Brushed Block Copolymer Micelles with pH-Sensitive Pendant Groups for Controlled Drug Delivery", PHARM RES, vol. 30, no. 8, 31 August 2013 (2013-08-31), pages 2077 - 2086, XP055347450, ISSN: 1573-904X
FENG WNANG ET AL.: "develop a drug delivery system by tethering doxorubicin onto the surface of AuNPs with a poly(ethylene glycol) space via an acid-labile linkage", vol. 5, 2011, AMERICAN CHEMICAL SOCIETY, pages: 3679 - 3692
TIAN-MENG SUN ET AL.: "a cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds", BIOMATERIALS, vol. 35, 2014, pages 836 - 845, XP028760825, DOI: doi:10.1016/j.biomaterials.2013.10.011
HYEJIN PARK ET AL., BIOMATERIALS, vol. 35, no. 10, 2014, pages 3480 - 3487
See also references of EP 3325440A4
TIAN-MENG SUN ET AL.: "Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds", BIOMATERIALS, vol. 35, no. 2, 18 October 2013 (2013-10-18), pages 836 - 845, XP028760825, ISSN: 1878-5905
FENG WANG ET AL.: "Doxorubicin-Tethered Responsive Gold Nanopaiticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells", ACS NANO, vol. 5, no. 5, 24 May 2011 (2011-05-24), pages 3679 - 3692, XP055347447, ISSN: 1936-0851
FENG WANG ET AL.: "Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells", ACS NANO, vol. 5, no. 5, 24 May 2011 (2011-05-24), pages 3679 - 3692, XP055347448, ISSN: 1936-0851
STEVEN M. ANSELL ET AL.: "3-(2-Pyridyldithio)propionic Acid Hydrazide as a Cross-Linker in the Formation of Liposome-Antibody Conjugates", BIOCONJUGATE CHEM., vol. 7, no. 4, 25 July 1996 (1996-07-25), pages 490 - 496, XP000637466, ISSN: 1043-1802
HYUN JIN LEE ET AL.: "Brushed Block Copolymer Micelles with pH-Sensitive Pendant Groups for Controlled Drug Delivery", PHARM RES, vol. 30, no. 8, 31 August 2013 (2013-08-31), pages 2077 - 2086, XP055347450, ISSN: 1573-904X
FENG WNANG ET AL.: "develop a drug delivery system by tethering doxorubicin onto the surface of AuNPs with a poly(ethylene glycol) space via an acid-labile linkage", vol. 5, 2011, AMERICAN CHEMICAL SOCIETY, pages: 3679 - 3692
TIAN-MENG SUN ET AL.: "a cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds", BIOMATERIALS, vol. 35, 2014, pages 836 - 845, XP028760825, DOI: doi:10.1016/j.biomaterials.2013.10.011
HYEJIN PARK ET AL., BIOMATERIALS, vol. 35, no. 10, 2014, pages 3480 - 3487
See also references of EP 3325440A4
Attorney, Agent or Firm:
LEE AND LI - LEAVEN IPR AGENCY LTD. (CN)
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