Title:
PHARMACEUTICAL COMPOSITION FOR BLOOD CELL RECOVERY AFTER CORD BLOOD TRANSPLANT
Document Type and Number:
WIPO Patent Application WO/2023/149443
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for blood cell recovery after allogeneic cord blood transplant, the pharmaceutical composition containing romiplostim as an active ingredient. The pharmaceutical composition is characterized by being administered starting the day after the transplant. The present invention also relates to a method for treating an allogeneic cord blood transplant recipient using the pharmaceutical composition.
Inventors:
CHIBA SHIGERU (JP)
KURITA NAOKI (JP)
SHIRAISHI NORIHIKO (JP)
KURITA NAOKI (JP)
SHIRAISHI NORIHIKO (JP)
Application Number:
PCT/JP2023/003140
Publication Date:
August 10, 2023
Filing Date:
February 01, 2023
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
KYOWA KIRIN CO LTD (JP)
KYOWA KIRIN CO LTD (JP)
International Classes:
A61K38/16; A61K38/18; A61P7/00; A61P43/00; C07K14/00; C07K14/535; C07K16/00; C07K19/00
Domestic Patent References:
| WO2020085467A1 | 2020-04-30 |
Foreign References:
| US20130259825A1 | 2013-10-03 |
Other References:
CHRISTAKOPOULOS GEORGIOS E.; DEFOR TODD E.; HAGE STEFANIE; WAGNER JOHN E.; LINDEN MICHAEL A.; BRUNSTEIN CLAUDIO; BEJANYAN NELLI; V: "Phase I Dose-Finding, Safety, and Tolerability Trial of Romiplostim to Improve Platelet Recovery After UCB Transplantation", TRANSPLANTATION AND CELLULAR THERAPY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 6, 2 March 2021 (2021-03-02), AMSTERDAM, NL , XP086635942, ISSN: 2666-6367, DOI: 10.1016/j.jtct.2021.02.033
TATSUTOSHI NAKAHATA: "Clinical applications of cytokines for hematopoietic stem cell transplantation", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 18, no. 15, 1 January 2000 (2000-01-01), JP , pages 211 (2189) - 217 (2195), XP009548433, ISSN: 0288-5514
KURITA N., Y. MARUYAMA, Y. SUEHARA, K. HATTORI, T. SAKAMOTO, T. KATO, Y. YOKOYAMA, N. OBARA, K. MARUO, K. HASHIMOTO, M. SAKATA-Y: "P453. Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial", BONE MARROW TRANSPLANTATION, NATURE PUBLISHING GROUP, GB, vol. 57, no. S1, 1 November 2022 (2022-11-01), GB , pages 346, XP093083302, ISSN: 0268-3369, DOI: 10.1038/s41409-022-01798-0
TATSUTOSHI NAKAHATA: "Clinical applications of cytokines for hematopoietic stem cell transplantation", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 18, no. 15, 1 January 2000 (2000-01-01), JP , pages 211 (2189) - 217 (2195), XP009548433, ISSN: 0288-5514
KURITA N., Y. MARUYAMA, Y. SUEHARA, K. HATTORI, T. SAKAMOTO, T. KATO, Y. YOKOYAMA, N. OBARA, K. MARUO, K. HASHIMOTO, M. SAKATA-Y: "P453. Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial", BONE MARROW TRANSPLANTATION, NATURE PUBLISHING GROUP, GB, vol. 57, no. S1, 1 November 2022 (2022-11-01), GB , pages 346, XP093083302, ISSN: 0268-3369, DOI: 10.1038/s41409-022-01798-0
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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