Title:
PHARMACEUTICAL COMPOSITION FOR COMBINED ADMINISTRATION COMPRISING T-CELL EXTRACELLULAR VESICLES AND ANTICANCER DRUG AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2023/013955
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for combined administration, comprising T-cell extracellular vesicles and an anticancer drug as active ingredients. By having confirmed that, when extracellular vesicles, which express, on the surface thereof, IL-2 isolated from T cells transfected with a vector comprising IL-2, a linker, and a transmembrane protein, are administered in combination with cisplatin or an anti-PD-L1 antibody, which are anticancer drugs, the anticancer effect is enhanced, extracellular vesicles expressing IL-2 on the surface thereof are provided as an agent for combined administration to treat cancer.
Inventors:
BAEK MOON-CHANG (KR)
YEA KYUNG MOO (KR)
JUNG DO KYUNG (KR)
YEA KYUNG MOO (KR)
JUNG DO KYUNG (KR)
Application Number:
PCT/KR2022/011016
Publication Date:
February 09, 2023
Filing Date:
July 27, 2022
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
International Classes:
A61K35/17; A61K38/20; A61K45/06; A61P35/00
Foreign References:
| KR20210027080A | 2021-03-10 | |||
| KR20180078173A | 2018-07-09 | |||
| KR20210043433A | 2021-04-21 |
Other References:
FITZGERALD WENDY, FREEMAN MICHAEL L., LEDERMAN MICHAEL M., VASILIEVA ELENA, ROMERO ROBERTO, MARGOLIS LEONID: "A System of Cytokines Encapsulated in ExtraCellular Vesicles", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 1 - 11, XP055787507, DOI: 10.1038/s41598-018-27190-x
TAO JIANG, CAICUN ZHOU, SHENGXIANG REN: "Role of IL-2 in cancer immunotherapy", ONCOIMMUNOLOGY, vol. 5, no. 6, 2 June 2016 (2016-06-02), pages 1 - 10, XP055743000, DOI: 10.1080/2162402X.2016.1163462
XU ZHIJIE, ZENG SHUANGSHUANG, GONG ZHICHENG, YAN YUANLIANG: "Exosome-based immunotherapy: a promising approach for cancer treatment", MOLECULAR CANCER, vol. 19, no. 1, 1 December 2020 (2020-12-01), GB , pages 160 - 160, XP055798385, ISSN: 1476-4598, DOI: 10.1186/s12943-020-01278-3
TAO JIANG, CAICUN ZHOU, SHENGXIANG REN: "Role of IL-2 in cancer immunotherapy", ONCOIMMUNOLOGY, vol. 5, no. 6, 2 June 2016 (2016-06-02), pages 1 - 10, XP055743000, DOI: 10.1080/2162402X.2016.1163462
XU ZHIJIE, ZENG SHUANGSHUANG, GONG ZHICHENG, YAN YUANLIANG: "Exosome-based immunotherapy: a promising approach for cancer treatment", MOLECULAR CANCER, vol. 19, no. 1, 1 December 2020 (2020-12-01), GB , pages 160 - 160, XP055798385, ISSN: 1476-4598, DOI: 10.1186/s12943-020-01278-3
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF: