Title:
PHARMACEUTICAL COMPOSITION COMPRISING POLYNUCLEOTIDES AND USE THEREOF FOR PREVENTION OR TREATMENT OF COVID-19
Document Type and Number:
WIPO Patent Application WO/2021/238982
Kind Code:
A1
Abstract:
The present application relates to a pharmaceutical composition comprising polynucleotides and use thereof for prevention or treatment of COVID-19. More specifically, disclosed in the present application is a composition used for prevention or treatment of COVID-19, comprising a polyriboinosinic-polyribocytidylic acid, an antibiotic or polyamino compound, a positive ion, and an optional antigen derived from novel coronavirus SARS-CoV-2. Also provided is use of the composition in preparation of a drug or vaccine for prevention or treatment of novel coronavirus SARS-CoV-2.
Inventors:
ZHANG YI (CN)
LIU YUAN (CN)
ZHANG NAN (CN)
LIU YUAN (CN)
ZHANG NAN (CN)
Application Number:
PCT/CN2021/096048
Publication Date:
December 02, 2021
Filing Date:
May 26, 2021
Export Citation:
Assignee:
LIAONING YISHENG BIOPHARMA CO LTD (CN)
BEIJING YISHENG XINGYE TECH CO LTD (CN)
HENAN YISHENG PHARMA CO LTD (CN)
BEIJING YISHENG XINGYE TECH CO LTD (CN)
HENAN YISHENG PHARMA CO LTD (CN)
International Classes:
A61K39/215; A61K39/39; A61P31/14
Foreign References:
| CN110944662A | 2020-03-31 | |||
| CN103405762A | 2013-11-27 | |||
| CN105396130A | 2016-03-16 | |||
| CN107198777A | 2017-09-26 | |||
| CN1095951A | 1994-12-07 | |||
| CN101166559A | 2008-04-23 | |||
| CN106075431A | 2016-11-09 | |||
| CN110974950A | 2020-04-10 | |||
| CN110944662A | 2020-03-31 | |||
| CN103405762A | 2013-11-27 | |||
| CN110951756A | 2020-04-03 | |||
| CN202010475388A | 2020-05-29 | |||
| CN103405762A | 2013-11-27 | |||
| CN111560074A | 2020-08-21 | |||
| CN111607605A | 2020-09-01 |
Other References:
ANONYMOUS: "New Crown Vaccine. Yisheng Biological Official Proclaims Breakthrough", SCIENTIFIC CHINESE, 10 June 2020 (2020-06-10), pages 1 - 5, XP055872728, Retrieved from the Internet [retrieved on 20211214]
TONG JIAO, CHENXI ZHU, HANYU LAI, CHUNCHAO FENG, DAPENG ZHOU: "Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19", VACCINES, vol. 9, no. 3, 22 March 2021 (2021-03-22), CH , pages 1 - 11, XP055872704, ISSN: 2076-393X, DOI: 10.3390/vaccines9030296
KALIMUDDIN SHIRIN, WIJAYA LIMIN, CHAN YVONNE F.Z., WONG ABIGAIL W.L., OH HELEN M.L., WANG LIN-FA, KASSIM JULAIHABEE A., ZHAO JING,: "A phase II randomized study to determine the safety and immunogenicity of the novel PIKA rabies vaccine containing the PIKA adjuvant using an accelerated regimen", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 51, 1 December 2017 (2017-12-01), AMSTERDAM, NL , pages 7127 - 7132, XP055872711, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2017.10.097
HAIXIANG LIN, YI ZHANG: "Mechanisem of Action of PICKCa Adjuvant and Its Therapeutic Vaccines", OPEN JOURNAL OF NATURE SCIENCE, vol. 03, no. 03, 1 January 2015 (2015-01-01), pages 70 - 80, XP055872721, ISSN: 2330-1724, DOI: 10.12677/OJNS.2015.33010
STANLEY A PLOTKIN ET AL.: "Vaccine", 2003, W. B. SAUNDERS COMPANY
See also references of EP 4159233A4
TONG JIAO, CHENXI ZHU, HANYU LAI, CHUNCHAO FENG, DAPENG ZHOU: "Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19", VACCINES, vol. 9, no. 3, 22 March 2021 (2021-03-22), CH , pages 1 - 11, XP055872704, ISSN: 2076-393X, DOI: 10.3390/vaccines9030296
KALIMUDDIN SHIRIN, WIJAYA LIMIN, CHAN YVONNE F.Z., WONG ABIGAIL W.L., OH HELEN M.L., WANG LIN-FA, KASSIM JULAIHABEE A., ZHAO JING,: "A phase II randomized study to determine the safety and immunogenicity of the novel PIKA rabies vaccine containing the PIKA adjuvant using an accelerated regimen", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 51, 1 December 2017 (2017-12-01), AMSTERDAM, NL , pages 7127 - 7132, XP055872711, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2017.10.097
HAIXIANG LIN, YI ZHANG: "Mechanisem of Action of PICKCa Adjuvant and Its Therapeutic Vaccines", OPEN JOURNAL OF NATURE SCIENCE, vol. 03, no. 03, 1 January 2015 (2015-01-01), pages 70 - 80, XP055872721, ISSN: 2330-1724, DOI: 10.12677/OJNS.2015.33010
STANLEY A PLOTKIN ET AL.: "Vaccine", 2003, W. B. SAUNDERS COMPANY
See also references of EP 4159233A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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