Title:
PHARMACEUTICAL COMPOSITION COMPRISING PRRX1 INHIBITOR FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2023/090884
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for prevention or treatment of cancer, the composition comprising a PRRX1 inhibitor that attenuates or inhibits the expression or activity of PRRX1 overexpressed in cancer tissues, particularly cancer-associated fibroblasts. Containing a PRRX1 inhibitor as an active ingredient, the pharmaceutical composition for prevention or treatment of cancer according to the present invention can inhibit the proliferation or activity of cancer tissues, especially, cancer-associated fibroblasts and facilitate the penetration of a cancer therapeutic agent into cancer tissues, with the resultant apoptotic promotion of cancer tissues, whereby the composition can effectively treat various PRRX1-expressing cancers.
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Inventors:
KIM SEOK HYUNG (KR)
LEE KEUN WOO (KR)
YEO SO YOUNG (KR)
LEE KEUN WOO (KR)
YEO SO YOUNG (KR)
Application Number:
PCT/KR2022/018172
Publication Date:
May 25, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K48/00; A61K31/7105; A61P35/00
Domestic Patent References:
| WO2013134649A1 | 2013-09-12 |
Foreign References:
| EP3461837A1 | 2019-04-03 |
Other References:
JOKO RYOJI, YAMADA DAISUKE, NAKAMURA MASAHIRO, YOSHIDA AKI, TAKIHIRA SHOTA, TAKAO TOMOKA, LU MING, SATO KOHEI, ITO TATSUO, KUNISAD: "PRRX1 promotes malignant properties in human osteosarcoma", TRANSLATIONAL ONCOLOGY, NEOPLASIA PRESS, UNITED STATES, vol. 14, no. 1, 1 January 2021 (2021-01-01), United States , pages 100960, XP093068527, ISSN: 1936-5233, DOI: 10.1016/j.tranon.2020.100960
DATABASE Nucleotide 26 October 2021 (2021-10-26), ANONYMOUS : "Homo sapiens paired related homeobox 1 (PRRX1), transcript variant pmx ", XP093068535, retrieved from NCBI Database accession no. NM_006902.5
LEE KEUN-WOO, YEO SO-YOUNG, GONG JEONG-RYEOL, KOO OK-JAE, SOHN INSUK, LEE WOO YONG, KIM HEE CHEOL, YUN SEONG HYEON, CHO YONG BEOM,: "PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093068540, DOI: 10.1038/s41467-022-30484-4
DATABASE Nucleotide 26 October 2021 (2021-10-26), ANONYMOUS : "Homo sapiens paired related homeobox 1 (PRRX1), transcript variant pmx ", XP093068535, retrieved from NCBI Database accession no. NM_006902.5
LEE KEUN-WOO, YEO SO-YOUNG, GONG JEONG-RYEOL, KOO OK-JAE, SOHN INSUK, LEE WOO YONG, KIM HEE CHEOL, YUN SEONG HYEON, CHO YONG BEOM,: "PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093068540, DOI: 10.1038/s41467-022-30484-4
Attorney, Agent or Firm:
PARK, Hyuk (KR)
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