Title:
PHARMACEUTICAL COMPOSITION CONTAINING ATPIF1 FOR TREATMENT OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2018/169282
Kind Code:
A2
Abstract:
The present invention relates to a pharmaceutical composition containing ATPase inhibitor factor 1 (ATPIF1) as an active ingredient for the prevention or treatment of diabetes or diabetic complications, and to a pharmaceutical composition containing ATP1F1 as an active ingredient for prevention or treatment of obesity. The composition containing ATPIF1, according to the present invention, has a diabetes treatment effect by promoting sugar absorption in muscle cells and improving insulin sensitivity, and has an obesity prevention or treatment effect by effects of suppressing fat synthesis in fat cells and promoting the browning of fat cells.
Inventors:
KIM HYEON SOO (KR)
Application Number:
PCT/KR2018/002933
Publication Date:
September 20, 2018
Filing Date:
March 13, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K38/16; A61K38/28
Domestic Patent References:
| WO1997034631A1 | 1997-09-25 | |||
| WO1996032478A1 | 1996-10-17 |
Foreign References:
| KR101058290B1 | 2011-08-22 | |||
| KR20140022909A | 2014-02-25 | |||
| KR20140006938A | 2014-01-16 | |||
| KR101330868B1 | 2013-11-18 | |||
| KR101324828B1 | 2013-11-01 | |||
| KR20110111267A | 2011-10-10 |
Other References:
WHITHAM M ET AL., NAT REV DRUG DISCOV., vol. 15, 2016, pages 719 - 29
LIGHTFOOT AP ET AL., CURR. OPIN. RHEUMATOL., vol. 28, 2016, pages 661
VAN RAAIJ MJ ET AL., BIOCHEMISTRY, vol. 35, 1996, pages 15618
CABEZON E ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 41334
H. NEURODER. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
CHEN, H. C.FARESE, R. V., ARTERIOSCLER. THROMB. VASE. BIOL., vol. 25, 2005, pages 482 - 4865
COOKE, D.BLOOM, S., NAT. REV. DRUG DISCOV., vol. 5, 2006, pages 919 - 1200
COOKE, D.BLOOM, S., NAT. REV. DRUG. DISCOV., vol. 5, 2006, pages 919 - 1200
AARON M CYESSC RONALD KANH, CURR. OPIN. ENDOCRINOL. DIABETES OBES., vol. 17, 2010, pages 143
See also references of EP 3597208A4
LIGHTFOOT AP ET AL., CURR. OPIN. RHEUMATOL., vol. 28, 2016, pages 661
VAN RAAIJ MJ ET AL., BIOCHEMISTRY, vol. 35, 1996, pages 15618
CABEZON E ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 41334
H. NEURODER. L. HILL: "The Proteins", 1979, ACADEMIC PRESS
CHEN, H. C.FARESE, R. V., ARTERIOSCLER. THROMB. VASE. BIOL., vol. 25, 2005, pages 482 - 4865
COOKE, D.BLOOM, S., NAT. REV. DRUG DISCOV., vol. 5, 2006, pages 919 - 1200
COOKE, D.BLOOM, S., NAT. REV. DRUG. DISCOV., vol. 5, 2006, pages 919 - 1200
AARON M CYESSC RONALD KANH, CURR. OPIN. ENDOCRINOL. DIABETES OBES., vol. 17, 2010, pages 143
See also references of EP 3597208A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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