Title:
PHARMACEUTICAL COMPOSITION CONTAINING DEMETHYLZEYLASTERAL FOR PREVENTION OR TREATMENT OF DISEASES CAUSED BY MUSCLE LOSS
Document Type and Number:
WIPO Patent Application WO/2023/249354
Kind Code:
A1
Abstract:
A composition containing demethylzeylasteral or a pharmaceutically acceptable salt thereof, according to the present invention, is highly effective at promoting muscle differentiation and inhibiting muscle degradation, as a glucocorticoid receptor antagonist that inhibits intracellular activity of the glucocorticoid receptor, in order to prevent or treat diseases caused by muscle loss.
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Inventors:
YANG HEE (KR)
SHIN SEO HYUN (KR)
YANG SEUNG HEE (KR)
KIM NA RA (KR)
YOON JUNG HAN (KR)
LEE KI WON (KR)
SHIN SEO HYUN (KR)
YANG SEUNG HEE (KR)
KIM NA RA (KR)
YOON JUNG HAN (KR)
LEE KI WON (KR)
Application Number:
PCT/KR2023/008463
Publication Date:
December 28, 2023
Filing Date:
June 19, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K31/19; A23K20/105; A23L33/10; A61P21/00
Domestic Patent References:
| WO2017070615A1 | 2017-04-27 |
Foreign References:
| US20110218143A1 | 2011-09-08 |
Other References:
ZHAO YUZU, HE JIANG, LI JUN, PENG XINGZHI, WANG XIANXING, DONG ZHEN, ZHAO ERHU, LIU YALING, WU ZONGHUI, CUI HONGJUAN: "Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 8, no. 10, GB , pages e3133 - e3133, XP093119237, ISSN: 2041-4889, DOI: 10.1038/cddis.2017.529
ZHANG KUI, FU GANG, PAN GUANGZHAO, LI CHONGYANG, SHEN LI, HU RENJIAN, ZHU SHUNQIN, CHEN YIBIAO, CUI HONGJUAN: "Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 9, no. 10, GB , XP093119238, ISSN: 2041-4889, DOI: 10.1038/s41419-018-1086-8
LI LIU; JI YI; FAN JUNTING; LI FURONG; LI YAN; WU MIANHUA; CHENG HAIBO; XU CHANGLIANG: "Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, DE, vol. 392, no. 5, 6 February 2019 (2019-02-06), DE , pages 593 - 603, XP036754296, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01614-5
ZHANG KUI, FU GANG, PAN GUANGZHAO, LI CHONGYANG, SHEN LI, HU RENJIAN, ZHU SHUNQIN, CHEN YIBIAO, CUI HONGJUAN: "Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis", CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, GB, vol. 9, no. 10, GB , XP093119238, ISSN: 2041-4889, DOI: 10.1038/s41419-018-1086-8
LI LIU; JI YI; FAN JUNTING; LI FURONG; LI YAN; WU MIANHUA; CHENG HAIBO; XU CHANGLIANG: "Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, DE, vol. 392, no. 5, 6 February 2019 (2019-02-06), DE , pages 593 - 603, XP036754296, ISSN: 0028-1298, DOI: 10.1007/s00210-019-01614-5
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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