Title:
PHARMACEUTICAL COMPOSITION CONTAINING DUSP1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/190511
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition containing a DUSP1 inhibitor. The pharmaceutical composition containing the DUSP1 inhibitor, according to the present invention, inhibits DUSP1 through an allosteric mechanism, thereby resolving the problem of inhibitors targeting an active site, and is effective in the prevention or treatment of DUSP1 enzyme-associated diseases such as hepatitis C, depression, and cancer such as liver cancer, breast cancer, and pancreatic cancer. Particularly, the DUSP1 inhibitor according to the present invention directly acts on the growth of neurons, thereby being very effective in the treatment of depression.
Inventors:
RYU SEONG EON (KR)
PARK TAE HYUN (KR)
LEE KWANG HWAN (KR)
KANG JU SEOP (KR)
KIM SHIN HEE (KR)
NAM KYOUNG TAE (KR)
LEE HYEON KYU (KR)
PARK TAE HYUN (KR)
LEE KWANG HWAN (KR)
KANG JU SEOP (KR)
KIM SHIN HEE (KR)
NAM KYOUNG TAE (KR)
LEE HYEON KYU (KR)
Application Number:
PCT/KR2018/002477
Publication Date:
October 18, 2018
Filing Date:
February 28, 2018
Export Citation:
Assignee:
UNIV HANYANG IND UNIV COOP FOUND (KR)
KOREA RES INST CHEMICAL TECH (KR)
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
A61K31/47
Domestic Patent References:
| WO2015187496A1 | 2015-12-10 |
Foreign References:
| US20040198716A1 | 2004-10-07 | |||
| KR20120079254A | 2012-07-12 | |||
| KR20150083353A | 2015-07-17 | |||
| KR20080077889A | 2008-08-26 |
Other References:
CHEN, Y.: "Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats", NEUROSCIENCE LETTERS, vol. 506, 2012, pages 327 - 331, XP028354241
CHOI, J. E.: "Suppression of dual specificity phosphatase I expression inhibits hepatitis C virus replication", PLOS ONE, vol. 10, no. 3, 2015, pages 1 - 11, XP055613440
SEO, H. K.: "Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer", ONCOTARGET, vol. 5, no. 2, 2014, pages 326 - 337, XP055613443
JEONG, K. -C.: "Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest", MOLECULAR BIOSYSTEMS, vol. 6, no. 8, 2010, pages 1503 - 1509, XP055613444
JEONG, K. -C.: "Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth", THE JOURNAL OF UROLOGY, vol. 191, 2014, pages 510 - 518, XP028813254
CANDIS ET AL.: "Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells", CANCER RES., vol. 74, 2014, pages 7498 - 7509
LIU ET AL.: "DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine", PLOS ONE, vol. 9, 2014, pages e84982
CHOI ET AL.: "Suppression of Dual Specificity Phosphatase I Expression Inhibits Hepatitis C Virus Replication", PLOS ONE, vol. 10, 2014, pages e0119172
DURIC ET AL.: "A negative regulator of MAP kinase causes depressive behavior", NATURE MEDICINE, vol. 16, 2010, pages 1328 - 1332
CHEN ET AL.: "Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats", NEUROSCI LETT, vol. 506, 2012, pages 327 - 331, XP028354241, DOI: 10.1016/j.neulet.2011.11.038
"Burger's Medical Chemistry and Drug Chemistry", vol. 1, 1995, pages: 172 - 178,949-982
ISHIMA ET AL.: "Potentiation of neurite outgrowthby brexpiprazole, a novel serotonin-dopamine activity modulator: A role for serotonin 5-HT1A and 5-HT2A receptors", EUR.NEUROPSYCHOPHARM., vol. 25, 2015, pages 505 - 511
See also references of EP 3603641A4
CHOI, J. E.: "Suppression of dual specificity phosphatase I expression inhibits hepatitis C virus replication", PLOS ONE, vol. 10, no. 3, 2015, pages 1 - 11, XP055613440
SEO, H. K.: "Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer", ONCOTARGET, vol. 5, no. 2, 2014, pages 326 - 337, XP055613443
JEONG, K. -C.: "Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest", MOLECULAR BIOSYSTEMS, vol. 6, no. 8, 2010, pages 1503 - 1509, XP055613444
JEONG, K. -C.: "Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth", THE JOURNAL OF UROLOGY, vol. 191, 2014, pages 510 - 518, XP028813254
CANDIS ET AL.: "Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells", CANCER RES., vol. 74, 2014, pages 7498 - 7509
LIU ET AL.: "DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine", PLOS ONE, vol. 9, 2014, pages e84982
CHOI ET AL.: "Suppression of Dual Specificity Phosphatase I Expression Inhibits Hepatitis C Virus Replication", PLOS ONE, vol. 10, 2014, pages e0119172
DURIC ET AL.: "A negative regulator of MAP kinase causes depressive behavior", NATURE MEDICINE, vol. 16, 2010, pages 1328 - 1332
CHEN ET AL.: "Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressant-like effect in rats", NEUROSCI LETT, vol. 506, 2012, pages 327 - 331, XP028354241, DOI: 10.1016/j.neulet.2011.11.038
"Burger's Medical Chemistry and Drug Chemistry", vol. 1, 1995, pages: 172 - 178,949-982
ISHIMA ET AL.: "Potentiation of neurite outgrowthby brexpiprazole, a novel serotonin-dopamine activity modulator: A role for serotonin 5-HT1A and 5-HT2A receptors", EUR.NEUROPSYCHOPHARM., vol. 25, 2015, pages 505 - 511
See also references of EP 3603641A4
Attorney, Agent or Firm:
HAEUM PATENT & LAW FIRM (KR)
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