Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION CONTAINING GLP-1 RECEPTOR AGONIST HAVING FUSED RING
Document Type and Number:
WIPO Patent Application WO/2022/202864
Kind Code:
A1
Abstract:
The present invention relates to: a compound, or a pharmacologically acceptable salt thereof, that has GLP-1 receptor agonist activity and that is useful as an agent for treating or preventing diseases involving the GLP-1 receptors; and a pharmaceutical composition containing the compound or the pharmacologically acceptable salt.　Provided is a compound represented by formula (I): (in the formula, A1 is C(R5), etc.; A2 is C(R6), etc.; A3 is C(R7), etc.; R5, R6, and R7 each independently are a hydrogen atom, etc.; R1 is a carboxy, etc.; R2 is a substituted or unsubstituted alkyl, etc.; -X- is -O-, etc.; the ring represented by (AAA) is a ring represented by (BBB) (in the formula, R10 each independently are a halogen, etc.; and s is 0, etc.); R13 each independently are a hydrogen atom, etc.; and R3 is a substituted or unsubstituted aromatic carbocyclic group, etc.), or a pharmacologically acceptable salt thereof.

More Like This:
JP20050229724-(4-PYRIDAZINYL)PYRAZOLE DERIVATIVE
JP2014040482NOVEL SALT OF 6-HETEROCYCLIC SUBSTITUTED HEXAHYDROPHENANTHRIDINE
WO/2014/023814NEW ANTIBACTERIAL COMPOUNDS
Inventors:
KITAMURA FUJIWARA MISATO (JP)
MAENO SHOMITSU (JP)
NISHIURA YUJI (JP)
Application Number:
PCT/JP2022/013362
Publication Date:
September 29, 2022
Filing Date:
March 23, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D401/14; A61K31/4709; A61K31/4725; A61K31/498; A61P3/04; A61P3/10; A61P43/00; C07D401/06; C07D405/14; C07D413/14; C07D417/14; C07D471/04
Domestic Patent References:
WO2018056453A12018-03-29
WO2019239319A12019-12-19
WO2021018023A12021-02-04
WO2022040600A12022-02-24
WO2012080471A12012-06-21
WO2009111700A22009-09-11
WO2010114824A12010-10-07
WO2018056453A12018-03-29
WO2018109607A12018-06-21
WO2019239319A12019-12-19
WO2019239371A12019-12-19
WO2020103815A12020-05-28
WO2020207474A12020-10-15
WO2020263695A12020-12-30
WO2021018023A12021-02-04
WO2021081207A12021-04-29
WO2021096284A12021-05-20
WO2021096304A12021-05-20
WO2021112538A12021-06-10
WO2021155841A12021-08-12
WO2021160127A12021-08-19
WO2021187886A12021-09-23
WO2021197464A12021-10-07
WO2021219019A12021-11-04
WO2021244645A12021-12-09
WO2021249492A12021-12-16
WO2021242817A12021-12-02
WO2021254470A12021-12-23
WO2021259309A12021-12-30
WO2022028572A12022-02-10
WO2022031994A12022-02-10
WO2022040600A12022-02-24
WO2012033195A12012-03-15
WO2019200120A12019-10-17
WO2020146682A12020-07-16
WO2021013135A12021-01-28
Foreign References:
CN113493447A2021-10-12
CN113480534A2021-10-08
CN113773310A2021-12-10
CN113816948A2021-12-21
CN113801136A2021-12-17
Other References:
ZHANG XIN; BELOUSOFF MATTHEW J.; ZHAO PEISHEN; KOOISTRA ALBERT J.; TRUONG TIN T.; ANG SHENG YU; UNDERWOOD CHRISTINA RYE; EGEBJERG : "Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 80, no. 3, 6 October 2020 (2020-10-06), AMSTERDAM, NL, pages 485 - 500, XP086318793, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2020.09.020
LANCET, vol. 374, 2009, pages 1606 - 1616
CLIN. INVEST., vol. 2, 2012, pages 59 - 72
"Isotopes in the Physical and Biomedical Sciences", LABELED COMPOUNDS (PART A, vol. 1, 1987
"Design of Prodrugs", 1985, ELSEVIER
THEODORA W GREENE: "Protective Groups in Organic Synthesis", JOHN WILEY & SONS
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: CONTRAST IMAGING COMPOSITION FOR CANCER

Next Patent: DISTRIBUTED LEDGER SYSTEM AND METHOD