Title:
PHARMACEUTICAL COMPOSITION CONTAINING IRRADIATED HEMATOPOIETIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2023/277114
Kind Code:
A1
Abstract:
The present invention relates to: a pharmaceutical composition containing a cell population that includes hematopoietic stem cells that have been irradiated; and a method for manufacturing the same. Specifically, the present invention relates to: a pharmaceutical composition for treating an ischemic disease and containing a cell population that includes hematopoietic stem cells that have been irradiated, the irradiation being 50 Gy or lower; and a method for manufacturing the same.
More Like This:
Inventors:
TAGUCHI AKIHIKO (JP)
TAURA AKIE (JP)
OKINAKA YUKA (JP)
OGAWA YUKO (JP)
KIMURA TAKAFUMI (JP)
TANAKA MITSUNOBU (JP)
YASUI KAZUTA (JP)
FUCHIZAKI AKIHIRO (JP)
YASUI TERUHITO (JP)
TAURA AKIE (JP)
OKINAKA YUKA (JP)
OGAWA YUKO (JP)
KIMURA TAKAFUMI (JP)
TANAKA MITSUNOBU (JP)
YASUI KAZUTA (JP)
FUCHIZAKI AKIHIRO (JP)
YASUI TERUHITO (JP)
Application Number:
PCT/JP2022/026147
Publication Date:
January 05, 2023
Filing Date:
June 30, 2022
Export Citation:
Assignee:
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE (JP)
JAPAN RED CROSS (JP)
JAPAN RED CROSS (JP)
International Classes:
A61K35/28; A61P9/00; A61P9/04; A61P9/10; C12N5/0789
Domestic Patent References:
| WO2019172279A1 | 2019-09-12 |
Foreign References:
| JP2002171965A | 2002-06-18 | |||
| JP2018518942A | 2018-07-19 | |||
| JP2001509778A | 2001-07-24 | |||
| JP2021110601A | 2021-08-02 | |||
| JP4481706B2 | 2010-06-16 |
Other References:
TAGUCHI A. ET AL.: "Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model.", THE JOURNAL OF CLINICAL INVESTIGATION, B M J GROUP, GB, vol. 114, no. 3, 1 August 2004 (2004-08-01), GB , pages 330 - 338, XP002428751, ISSN: 0021-9738, DOI: 10.1172/JCI200420622
PEROTTI CESARE, ARICI VITTORIO, CERVIO MARILA, DEL FANTE CLAUDIA, CALLIADA FABRIZIO, GNECCHI MASSIMILIANO, CIUFFREDA MARIA CHIARA,: "Allogeneic Lethally Irradiated Cord Blood Mononuclear Cells in No-Option Critical Limb Ischemia: A “Box of Rain”", STEM CELLS AND DEVELOPMENT, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 22, no. 20, 15 October 2013 (2013-10-15), US , pages 2806 - 2812, XP093020336, ISSN: 1547-3287, DOI: 10.1089/scd.2013.0172
AKAGI, YUKO: "Mononuclear cells by y-irradiation of healthy human peripheral blood", SHôWA-IGAKKAI-ZASSHI = THE JOURNAL OF THE SHOWA MEDICAL ASSOCIATION, SHôWA DAIGAKU, JAPAN, vol. 57, no. 4, 1 January 1997 (1997-01-01), Japan , pages 379 - 384, XP009542411, ISSN: 0037-4342
OGAWA, YUKO ET AL.: "Development of autologous hematopoietic stem cell preparation for regenerative medicine", CEREBRAL BLOOD FLOW AND METABOLISM, JAPANESE SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM, JAPAN, vol. 33, no. 1, 13 November 2021 (2021-11-13) - 13 November 2021 (2021-11-13), JAPAN , pages 100, XP009542412, ISSN: 0915-9401
PEROTTI ET AL.: "Allogeneic lethally irradiated cord blood mononuclear cells in no-option critical limb ischemia: a ''box of rain", STEM CELLS DEV, vol. 22, no. 20, 15 October 2013 (2013-10-15), pages 2806 - 12, XP093020336, DOI: 10.1089/scd.2013.0172
WILLIAM FC ET AL., J. CLIN INVEST, 1984
EAVES C ET AL., WILLIAMS HEMATOLOGY, 1995
KIKUCHI-TAURA ET AL., STROKE, vol. 51, no. 4, April 2020 (2020-04-01), pages 1279 - 1289
KASAHARA ET AL., TRANSL RES, vol. 176, October 2016 (2016-10-01), pages 69 - 80
PEROTTI CESARE, ARICI VITTORIO, CERVIO MARILA, DEL FANTE CLAUDIA, CALLIADA FABRIZIO, GNECCHI MASSIMILIANO, CIUFFREDA MARIA CHIARA,: "Allogeneic Lethally Irradiated Cord Blood Mononuclear Cells in No-Option Critical Limb Ischemia: A “Box of Rain”", STEM CELLS AND DEVELOPMENT, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 22, no. 20, 15 October 2013 (2013-10-15), US , pages 2806 - 2812, XP093020336, ISSN: 1547-3287, DOI: 10.1089/scd.2013.0172
AKAGI, YUKO: "Mononuclear cells by y-irradiation of healthy human peripheral blood", SHôWA-IGAKKAI-ZASSHI = THE JOURNAL OF THE SHOWA MEDICAL ASSOCIATION, SHôWA DAIGAKU, JAPAN, vol. 57, no. 4, 1 January 1997 (1997-01-01), Japan , pages 379 - 384, XP009542411, ISSN: 0037-4342
OGAWA, YUKO ET AL.: "Development of autologous hematopoietic stem cell preparation for regenerative medicine", CEREBRAL BLOOD FLOW AND METABOLISM, JAPANESE SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM, JAPAN, vol. 33, no. 1, 13 November 2021 (2021-11-13) - 13 November 2021 (2021-11-13), JAPAN , pages 100, XP009542412, ISSN: 0915-9401
PEROTTI ET AL.: "Allogeneic lethally irradiated cord blood mononuclear cells in no-option critical limb ischemia: a ''box of rain", STEM CELLS DEV, vol. 22, no. 20, 15 October 2013 (2013-10-15), pages 2806 - 12, XP093020336, DOI: 10.1089/scd.2013.0172
WILLIAM FC ET AL., J. CLIN INVEST, 1984
EAVES C ET AL., WILLIAMS HEMATOLOGY, 1995
KIKUCHI-TAURA ET AL., STROKE, vol. 51, no. 4, April 2020 (2020-04-01), pages 1279 - 1289
KASAHARA ET AL., TRANSL RES, vol. 176, October 2016 (2016-10-01), pages 69 - 80
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
Download PDF:
Previous Patent: HUMANIZED ANTIBODY CAPABLE OF BINDING TO HEG1 PROTEIN
Next Patent: REAR STRUCTURE OF VEHICLE
Next Patent: REAR STRUCTURE OF VEHICLE