Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DYSREGULATION-RELATED DISEASES COMPRISING OXIDIZED IMMUNOGLOBULIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/216027
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating immune dysregulation-related diseases, comprising oxidized immunoglobulin as an active ingredient and a preventive or therapeutic method using same. More specifically, the present invention can provide: a pharmaceutical composition for treating allergic diseases, chronic inflammatory diseases, autoimmune diseases or malignant tumor diseases, comprising as an active ingredient oxidized immunoglobulin obtained through artificially induced oxidation; and a novel immunomodulatory therapy which, by administering the composition to patients with the diseases, is differentiated from existing immunoglobulin therapeutic agents and more effective.
Inventors:
NAHM DONG HO (KR)
Application Number:
PCT/KR2022/004917
Publication Date:
October 13, 2022
Filing Date:
April 06, 2022
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
C07K16/00; A61K39/00; A61P29/00; A61P35/00; A61P37/08
Foreign References:
| US20160032018A1 | 2016-02-04 | |||
| KR19980702515A | 1998-07-15 |
Other References:
EMMI L., F. CHIARINI: "The role of intravenous immunoglobulin therapy in autoimmune and inflammatory disorders", NEUROL. SCI., vol. 23, 30 April 2002 (2002-04-30), pages S1 - S8, XP055975185
OMERSEL, J. ; JURGEC, I. ; CUCNIK, S. ; KVEDER, T. ; ROZMAN, B. ; SODIN-SEMRL, S. ; BOZIC, B.: "Autoimmune and proinflammatory activity of oxidized immunoglobulins", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 7, 1 July 2008 (2008-07-01), NL , pages 523 - 529, XP022849930, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2008.04.005
DAS MRINMOY, KARNAM ANUPAMA, STEPHEN-VICTOR EMMANUEL, GILARDIN LAURENT, BHATT BHARAT, KUMAR SHARMA VARUN, RAMBABU NARESH, PATIL VE: "Intravenous immunoglobulin mediates anti-inflammatory effects in peripheral blood mononuclear cells by inducing autophagy", CELL DEATH & DISEASE, vol. 11, no. 1, 1 January 2020 (2020-01-01), XP055975183, DOI: 10.1038/s41419-020-2249-y
OMERSEL, J. ; JURGEC, I. ; CUCNIK, S. ; KVEDER, T. ; ROZMAN, B. ; SODIN-SEMRL, S. ; BOZIC, B.: "Autoimmune and proinflammatory activity of oxidized immunoglobulins", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 7, no. 7, 1 July 2008 (2008-07-01), NL , pages 523 - 529, XP022849930, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2008.04.005
DAS MRINMOY, KARNAM ANUPAMA, STEPHEN-VICTOR EMMANUEL, GILARDIN LAURENT, BHATT BHARAT, KUMAR SHARMA VARUN, RAMBABU NARESH, PATIL VE: "Intravenous immunoglobulin mediates anti-inflammatory effects in peripheral blood mononuclear cells by inducing autophagy", CELL DEATH & DISEASE, vol. 11, no. 1, 1 January 2020 (2020-01-01), XP055975183, DOI: 10.1038/s41419-020-2249-y
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF: