Title:
VACCINE COMPOSITION FOR PREVENTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS TYPE 2 INFECTIOUS DISEASE, HAVING IMPROVED NEUTRALIZATION POTENCY
Document Type and Number:
WIPO Patent Application WO/2022/216028
Kind Code:
A1
Abstract:
The present invention relates to a vaccine composition for preventing severe acute respiratory syndrome coronavirus type 2 infectious disease. The present invention enables mass-production in animal cells by using an RBD domain mutant of a spike protein of severe acute respiratory syndrome coronavirus type 2, can effectively induce antigen production as an antigen, and can exhibit excellent effects in disease prevention as a vaccine.
Inventors:
JEONG DAE GWIN (KR)
YOON SUN WOO (KR)
KANG JUNG AH (KR)
SONG DAE SUB (KR)
YOON SUN WOO (KR)
KANG JUNG AH (KR)
SONG DAE SUB (KR)
Application Number:
PCT/KR2022/004921
Publication Date:
October 13, 2022
Filing Date:
April 06, 2022
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07K14/005; A61K39/215; A61P31/14; C12N7/00
Foreign References:
| KR20070052273A | 2007-05-21 | |||
| CN111944064A | 2020-11-17 |
Other References:
KANG LIN, HE GUIJUAN, SHARP AMANDA K., WANG XIAOFENG, BROWN ANNE M., MICHALAK PAWEL, WEGER-LUCARELLI JAMES: "A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation", BIORXIV, 17 February 2021 (2021-02-17), XP055975660, Retrieved from the Internet [retrieved on 20221027], DOI: 10.1101/2021.02.13.431090
DATABASE PROTEIN 22 January 2021 (2021-01-22), ANONYMOUS : "Log in An official website of the United States government TITLE Molecular Characterization and a single-nucleotide insertion resulting in ORF8 deletion in SARS-CoV-2 during first and second waves outbreaks in Hiroshima JOURNAL Unpublished REFERENCE 2 (residues 1 to 1282) AUTHORS", XP055975663, retrieved from NCBI Database accession no. BCN86353.1
SANTOS JADSON C., PASSOS GERALDO A.: "The high infectivity of SARS-CoV-2 B.1.1.7 is associated with increased interaction force between Spike-ACE2 caused by the viral N501Y mutation", BIORXIV, 1 January 2021 (2021-01-01), XP055975667, Retrieved from the Internet [retrieved on 20221027], DOI: 10.1101/2020.12.29.424708
DATABASE PROTEIN 22 January 2021 (2021-01-22), ANONYMOUS : "Log in An official website of the United States government TITLE Molecular Characterization and a single-nucleotide insertion resulting in ORF8 deletion in SARS-CoV-2 during first and second waves outbreaks in Hiroshima JOURNAL Unpublished REFERENCE 2 (residues 1 to 1282) AUTHORS", XP055975663, retrieved from NCBI Database accession no. BCN86353.1
SANTOS JADSON C., PASSOS GERALDO A.: "The high infectivity of SARS-CoV-2 B.1.1.7 is associated with increased interaction force between Spike-ACE2 caused by the viral N501Y mutation", BIORXIV, 1 January 2021 (2021-01-01), XP055975667, Retrieved from the Internet
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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