Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER DISEASES, CONTAINING LICORICE EXTRACT CONTAINING GLYCYRRHIZIN AND LIQUIRITIN
Document Type and Number:
WIPO Patent Application WO/2017/188499
Kind Code:
A1
Abstract:
The present invention provides a composition containing a licorice extract in which the content ratio of glycyrrhizin to liquiritin is respectively 1.5-1.8 to 1, by extracting licorice and then adding an excipient and spray drying the same. The composition, containing the licorice extract, of the present invention, can be useful in pharmaceutical and food fields as a pharmaceutical composition for preventing or treating liver diseases or as a food composition for improving liver function.
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Inventors:
KWON SUK HYUNG (KR)
JUNG JAE CHUL (KR)
KIM KYUNG MI (KR)
JUNG JAE CHUL (KR)
KIM KYUNG MI (KR)
Application Number:
PCT/KR2016/005593
Publication Date:
November 02, 2017
Filing Date:
May 26, 2016
Export Citation:
Assignee:
NOVAREX CO LTD (KR)
International Classes:
A61K36/484; A61K31/352; A61K31/704
Domestic Patent References:
| WO2016026139A1 | 2016-02-25 |
Foreign References:
| CN103316074A | 2013-09-25 |
Other References:
ADIANTI, M. ET AL.: "A nti-hepatitis C Virus Compounds Obtained from Glycyrrhiza Uralensis and Other Glycyrrhiza Species", MICROBIOLOGY AND IMMUNOLOGY, vol. 58, no. 3, 2014, pages 180 - 187, XP055435556
LIU, H. ET AL.: "Systems Approaches and Polypharmacology for Drug Discovery from Herbal Medicines: An Example Using Licorice", JOURNAL OF ETHNOPHARMACOLOGY, vol. 146, no. 3, 14 February 2013 (2013-02-14), pages 773 - 793, XP028526255
CHEN, H. -J. ET AL.: "Glycyrrhetinic Acid Suppressed NF-kappaB Activation in TNF-alpha-induced Hepatocytes", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 62, no. 3, 5 January 2014 (2014-01-05), pages 618 - 625, XP055435557
YU , J. -Y. ET AL.: "Anti-inflanimatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver", MOLECULES, vol. 20, no. 7, 20 July 2015 (2015-07-20), pages 13041 - 13054, XP055435559
JUNG, J. -C. ET AL.: "Hepatoprotective Effect of licorice, the Root of Glycyrrhiza Uralens is Fischer, in Alcohol-induced Fatty Liver Disease", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 16, 22 January 2016 (2016-01-22), pages 19 - 29, XP021233435
LIU, H. ET AL.: "Systems Approaches and Polypharmacology for Drug Discovery from Herbal Medicines: An Example Using Licorice", JOURNAL OF ETHNOPHARMACOLOGY, vol. 146, no. 3, 14 February 2013 (2013-02-14), pages 773 - 793, XP028526255
CHEN, H. -J. ET AL.: "Glycyrrhetinic Acid Suppressed NF-kappaB Activation in TNF-alpha-induced Hepatocytes", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 62, no. 3, 5 January 2014 (2014-01-05), pages 618 - 625, XP055435557
YU , J. -Y. ET AL.: "Anti-inflanimatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver", MOLECULES, vol. 20, no. 7, 20 July 2015 (2015-07-20), pages 13041 - 13054, XP055435559
JUNG, J. -C. ET AL.: "Hepatoprotective Effect of licorice, the Root of Glycyrrhiza Uralens is Fischer, in Alcohol-induced Fatty Liver Disease", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 16, 22 January 2016 (2016-01-22), pages 19 - 29, XP021233435
Attorney, Agent or Firm:
KIM, Jung Su (KR)
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