PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF BLOOD CANCER COMPRISING SURF4 INHIBITOR

Title:

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF BLOOD CANCER COMPRISING SURF4 INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2023/113129

Kind Code:

A1

Abstract:

One aspect relates to a pharmaceutical composition for the prevention or treatment of blood cancer, comprising a surfeit locus protein 4 (SURF4) inhibitor. The composition according to one aspect inhibits SURF4 to increase the expression of pJNK and decrease the expression of pERK and pAKT, and thus apoptosis of blood cancer cells is increased, thereby exhibiting an effect of preventing or treating blood cancers. In addition, by administering the composition according to one aspect together with an existing anticancer agent, a synergistic effect showing more significant apoptosis than when an existing anticancer agent was administered was confirmed, which can contribute to the blood cancer treatment market/industry.

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Inventors:

LEE DONGJUN (KR)
KIM JAYOUNG (KR)

Application Number:

PCT/KR2022/010360

Publication Date:

June 22, 2023

Filing Date:

July 15, 2022

Export Citation:

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Assignee:

NAT UNIV PUSAN IND UNIV COOP FOUND (KR)

International Classes:

A61K48/00; A23L33/10; A61K31/337; A61K31/7072; A61K31/7105; A61K45/06; A61P35/02

Domestic Patent References:

WO2021083555A1

2021-05-06

Foreign References:

US20090192111A1	2009-07-30
KR20040107145A	2004-12-20

Other References:

KIM JAYOUNG, HONG CHAE MI, PARK SU MIN, SHIN DONG HOON, KIM JEE YEON, KWON SANG-MO, KIM JAE HO, KIM CHI DAE, LIM DAE-SIK, LEE DONG: "SURF4 has oncogenic potential in NIH3T3 cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 502, no. 1, 1 July 2018 (2018-07-01), Amsterdam NL , pages 43 - 47, XP093072649, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2018.05.116
YUE YONGFANG, XIA LILI, XU SHANSHAN, WANG CONGHUI, WANG XINYU, LU WEIGUO, XIE XING: "SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells", JOURNAL OF GYNECOLOGIC ONCOLOGY, vol. 31, no. 4, XP093072651, ISSN: 2005-0380, DOI: 10.3802/jgo.2020.31.e46

Attorney, Agent or Firm:

ISIS IP LAW LLC (KR)

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